A5024835059- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- SARS-CoV-2 and COVID-19 Research
- Cerebral Palsy and Movement Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Advertising and Communication Studies
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- Journalism and Media Studies
- Cytokine Signaling Pathways and Interactions
- COVID-19 and Mental Health
- Functional Brain Connectivity Studies
- Bone and Joint Diseases
- Mindfulness and Compassion Interventions
- Brain Tumor Detection and Classification
- Public Policy and Governance
- Full-Duplex Wireless Communications
- Lymphadenopathy Diagnosis and Analysis
- Spinal Cord Injury Research
- Ultrasound Imaging and Elastography
- Amyotrophic Lateral Sclerosis Research
Universitat Autònoma de Barcelona
2016-2025
Vall d'Hebron Institut de Recerca
2016-2025
Vall d'Hebron Hospital Universitari
2009-2025
Centre d'Esclerosi Múltiple de Catalunya
2012-2024
John Wiley & Sons (United States)
2024
Hudson Institute
2024
Hebron University
2013-2022
Hospital Universitario 12 De Octubre
2022
Spanish Multiple Sclerosis Network
2009-2022
St. Michael's Hospital
2017-2019
Natural history studies have identified factors that predict evolution to multiple sclerosis or risk of disability accumulation over time. Although these are based on large multicentre cohorts with long follow-ups, they limitations such as lack standardized protocols, a retrospective data collection systematic magnetic resonance imaging acquisition and analysis protocol, often resulting in failure take oligoclonal bands into account joint covariates the prediction models. To overcome some...
Abstract Objective Many patients with multiple sclerosis (MS) are currently receiving treatment interferon (IFN)–β. Early identification of nonresponder is crucial to try different therapeutic approaches. We investigated various criteria response assess which criterion better identifies a poor response. Methods studied relapsing‐remitting MS (RRMS) treated IFN‐β and followed them up for at least 2 years. Expanded Disability Status Score was scored every 3 months relapses were recorded....
Progression independent of relapse activity (PIRA) is the main event responsible for irreversible disability accumulation in relapsing multiple sclerosis (MS).To investigate clinical and neuroimaging predictors PIRA at time first demyelinating attack factors associated with long-term outcomes people who present PIRA.This cohort study, conducted from January 1, 1994, to July 31, 2021, included patients a sclerosis; were recruited 1 study center Spain. Patients excluded if they refused...
Background: As a symptom of multiple sclerosis (MS), fatigue is difficult to manage because its unknown etiology, the lack efficacy drugs tested date and absence consensus about which would be ideal measure assess fatigue. Objective: Our aim was frequency in sample MS patients healthy controls (HC) using two scales, Fatigue Severity Scale (FSS) Modified Impact (MFIS) with physical, cognitive psychosocial subscales. We also studied relationship has depression, disability interferon beta....
The presence of oligoclonal bands in clinically isolated syndromes is an independent risk factor for developing multiple sclerosis and has been largely excluded from the more recent diagnostic criteria. Therefore, our objective was to explore value context 2010 McDonald criteria, especially patients fulfilling exclusively dissemination space at baseline. For this purpose, we selected 566 a syndrome inception cohort who had IgG determination sufficient data on baseline brain MRI assess time....
Abstract Background and purpose Information regarding multiple sclerosis (MS) patients with the 2019 novel coronavirus disease (COVID‐19) is scarce. The study objective was to describe incidence characteristics of MS COVID‐19, identify susceptibility severity risk factors assess proportion positive severe acute respiratory syndrome 2 (SARS‐CoV‐2) serologies according disease‐modifying treatments. Methods This a retrospective an cohort analysing data collected between February May 2020. Cases...
<h3>Objective:</h3> To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. <h3>Methods:</h3> Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing definite MS (CIS-CDMS) who remained as during a 2-year minimum follow-up (CIS-CIS). We determined levels neurofascin, semaphorin 3A, fetuin A, glial fibrillary acidic protein, neurofilament light (NfL) heavy...
Background: The usefulness of performing a spinal cord (SC) magnetic resonance imaging (MRI) in all clinically isolated syndromes (CIS) is controversial. Objective: To assess the value SC lesions for predicting multiple sclerosis (MS) diagnosis and disability accrual CIS. Methods: Concerning MS (2010 McDonald), adjusted Cox regression analyses were performed increasingly specific CIS groups: cases ( n = 207), non-SC 143), with abnormal brain MRI 90) not fulfilling 2010 67). For outcome...
Early treatment is associated with better long-term outcomes in patients a first demyelinating event and early multiple sclerosis (MS). However, magnetic resonance (MR) findings are not usually integrated to construct propensity scores (PSs) when evaluating outcomes. We assessed the association of receiving very risk disability including an MR score (MRS) event.
Emerging concepts in the early detection of multiple sclerosis (MS) progression reveal that disability accumulation can start disease course. Aging MS is increasingly recognized as a key factor for and accrual. We evaluate prognostic impact age cohort patients experiencing first demyelinating event (FDE), using variety outcomes, including some not previously assessed age-specific studies. Patients aged 18-50 years, within 3 months from FDE, were prospectively included since 1994 categorized...
Background: Cognitive impairment is frequent in multiple sclerosis (MS) and lacks effective treatment. rehabilitation widely applied neurorehabilitation settings. Functional magnetic resonance imaging (fMRI) may help investigating changes brain activity provide a tool to assess the efficacy of rehabilitation. Aim: To investigate effect on as measured by fMRI cognitive programme patients with MS impairment. Method: Fifteen five healthy subjects were recruited. Neuropsychological assessments...
To investigate the association between activity during interferon-beta (IFNβ) therapy and disability outcomes in patients with relapsing-remitting multiple sclerosis (RRMS).A longitudinal study based on two previously described cohorts of IFNβ-treated RRMS was conducted. Patients were classified according to clinical after 2 years (clinical cohort) or radiological 1 year (magnetic resonance imaging (MRI) cohort). Multivariate Cox models calculated for early disease predicting long-term...
To investigate the effect of menarche, pregnancies, and breastfeeding on risk developing multiple sclerosis (MS) disability accrual using a multivariate approach based large prospective cohort patients with clinically isolated syndrome (CIS).A cross-sectional survey reproductive information female participants in CIS was performed. We examined relationship age at menarche definite MS (CDMS), McDonald 2010 MS, Expanded Disability Status Scale (EDSS) 3.0 6.0. The pregnancy (before after CIS)...
To explore the long-term outcomes of patients with clinically isolated syndromes from Barcelona cohort.We selected a follow-up longer than 10 years to (1) estimate risks multiple sclerosis (MS) and disability accumulation according baseline number T2 lesions compare treated versus untreated early delayed treatment, (2) study features aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6.0 at years).In all, 401 were included (mean 14.4 (standard deviation 2.9) years). A higher was...
To explore whether time to diagnosis, treatment initiation, and age reach disability milestones have changed in patients with clinically isolated syndrome (CIS) according different multiple sclerosis (MS) diagnostic criteria periods.This retrospective study was based on data collected prospectively from the Barcelona-CIS cohort between 1994 2020. Patients were classified into 5 periods MS criteria, times diagnosis initiation evaluated. The at which reached an Expanded Disability Status Scale...
To assess the added value of optic nerve region (by using visual evoked potentials [VEPs]) to current diagnostic criteria.From Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information dissemination in space (DIS), region, and time at baseline (n = 388) were selected. Modified DIS (modDIS) criteria constructed by adding regions. The modDIS evaluated univariable Cox proportional hazard regression analyses second attack as outcome. A subset these who had least 10...
Intrathecal production of kappa free light chains occurs in multiple sclerosis and can be measured using the chain index. Kappa index values determined more easily than oligoclonal bands detection seem sensitive immunoglobulin (Ig)G to diagnose sclerosis. We assessed value bands, cut-offs 5.9, 6.6 10.61, IgG with prospectively acquired data from a clinically isolated syndrome inception cohort. selected patients sufficient determine positivity, MRI dissemination space time, quantities paired...
Abstract Clinical trials with interferons in relapsing–remitting multiple sclerosis have shown a modest effect on disability using fixed definitions of treatment failure to measure disease progression. However, the course disease, may be influenced by interrater variability and frequent remissions. Thus, purpose this study was assess clinical usefulness different criteria cohort patients treated interferon β. We studied 252 follow‐up more than 2 years. used four increasing stringency (1...
To study the contribution of symptomatic lesion in establishing multiple sclerosis (MS) diagnosis and prognosis.We performed an observational based on a prospective clinically isolated syndrome (CIS) cohort 1,107 patients recruited for clinical brain MRI follow-up from 1995 to 2014. Eligible (n = 954) were divided into 4 groups according baseline MRI: with normal 290); single asymptomatic 18); cord/brainstem 35); more than 1 611). For each group, we studied risk second attack, 2005 McDonald...
Vaccination in patients with highly active multiple sclerosis (MS) requiring prompt treatment initiation may result impaired vaccine responses and/or delay.
Introduction— Multiple sclerosis (MS) is an autoimmune disorder, but unique antigen has not been found. Antiganglioside antibodies (AGA) have reported in MS, nevertheless, a clinical significance of AGA MS established. The aims this study were to sera patients and investigate relationships between course MS. Material methods— 42 with who fulfilled the criteria clinically definite disease (59% RRMS, 21% SPMS, 20% PPMS), 89 systemic lupus erythematosus 36 healthy controls studied. A...
We aimed to single out multiple sclerosis (MS) cases with poor outcome after natalizumab withdrawal and identify predictive variables. ascertained 47 withdrawals, compared their pre- post-natalizumab periods. objectively defined significant clinical worsening as a 2-step increase in Expanded Disability Status Scale (EDSS). performed regression models. As group, annualized relapse rate (ARR) was lower the period, there were no differences mean number of gadolinium (Gd)-enhancing lesions...
Background: Multiple sclerosis (MS) misdiagnosis may cause physical and emotional damage to patients. Objectives: The objective of this study is determine the frequency characteristics MS in patients referred Sclerosis Centre Catalonia. Methods: We designed a prospective including all new consecutive our centre between July 2017 June 2018. Instances were identified, referral diagnosis final compared after 1 year follow-up. Association with magnetic resonance imaging (MRI) findings, presence...
The effect of disease-modifying therapies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine response is unclear.We aim to determine the immunological responses SARS-CoV-2 in multiple sclerosis (MS) and anti-CD20-treated patients with other autoimmune diseases (AID).Humoral cellular we determined before 30-90 days after vaccination MS AID two Catalan centers.457 were enrolled. Findings showed that humoral decreased under anti-CD20s or sphingosine 1-phosphate receptor...