A5040171201- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Light effects on plants
- CRISPR and Genetic Engineering
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Food Quality and Safety Studies
- Cardiovascular Health and Disease Prevention
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Genomics and Chromatin Dynamics
- Cardiovascular Function and Risk Factors
- Cerebrovascular and genetic disorders
- Sesquiterpenes and Asteraceae Studies
- Influenza Virus Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protein Tyrosine Phosphatases
- Fermentation and Sensory Analysis
- Phytoestrogen effects and research
- Parathyroid Disorders and Treatments
- Botanical Studies and Applications
Yale University
2020-2024
Whitney Museum of American Art
2022-2024
First Affiliated Hospital of Zhengzhou University
2017-2024
Shandong Academy of Sciences
2023
Qilu University of Technology
2023
National Health and Family Planning Commission
2023
Nanchang University
2016-2022
First Affiliated Hospital of Nanchang University
2016-2022
Zhejiang University
2015-2020
Ministry of Agriculture and Rural Affairs
2018
The mitotic activity of root apical meristem (RAM) is critical to primary growth and development. Previous studies have identified the roles ROOT GROWTH FACTOR 1 (RGF1), a peptide ligand, its receptors, RGF1 INSENSITIVEs (RGIs), clade five leucine-rich-repeat receptor-like kinases, in promoting cell division RAM, which determines length. However, downstream signaling components remain elusive. In this study, we identify complete mitogen-activated protein kinase (MAPK or MPK) cascade,...
Abstract Distant metastasis is the major cause of colon cancer (CC) treatment failure. SAD1/UNC84 domain protein‐2 (SUN2) a key component linker nucleoskeleton and cytoskeleton (LINC) complexes that may be relevant for in several cancers. Here, we first confirmed SUN2 levels were significantly lower primary CC tissues distant than normal tissues, high expression predicted good overall survival. Overexpression or knockdown inhibited promoted cell migration invasion vitro , respectively....
Plakoglobin is a tumor suppressor gene in lung cancer; however, the mechanism by which it downregulated cancer largely unknown. The aim of present study was to investigate whether histone deacetylases (HDACs) regulate plakoglobin expression cancer. effects overexpression or knockdown HDAC7 on were determined using stably transfected cell lines. Chromatin immunoprecipitation assays performed elucidate mechanisms underlying HDAC7‑induced suppression plakoglobin. A Cell Counting Kit‑8 and...
This retrospective study aimed to investigate the prognostic significance of pretreatment lymphocyte-to-monocyte ratio (LMR) in locally advanced cervical cancer and its effect on overall survival. The usual blood routine test was quantitatively performed detect LMR. Signal strengths human papilloma virus (HPV) type DNA detected samples using hybrid capture 2 were analyzed relative light units (RLU) compared with 1 pg/mL HPV 16 DNA-positive control (RLU/PC) samples. A total 1.0 RLU/PC (~1...
R2R3-MYB transcription factor MYB51 is known to control indole glucosinolate (indole GSL) biosynthesis in Arabidopsis. Here, two copies of BoaMYB51 have been isolated Chinese kale (Brassica oleracea var. alboglabra Bailey), designated BoaMYB51.1 and BoaMYB51.2, which exhibit overlapping but distinct expression levels among different organs respond upstream signaling molecules a similar pattern. It has demonstrated structural functional conservation between BoaMYB51s AtMYB51 by phylogenetic...
Cerebral small vessel disease (CSVD) refers to a common cerebrovascular and white matter hyperintensities (WMHs) constitute typical feature of CSVD. However, there has not been large number studies investigating the relationship between lipid profile components WMHs.Altogether, 1019 patients with CSVD were enrolled at First Affiliated Hospital Zhengzhou University April 2016 December 2021. Baseline data collected for all patients, including demographic characteristics clinical data. WMH...
Autonomic Nervous System (ANS) dysfunction may be involved in the pathogenesis of Cerebral Small Vessel Disease (CSVD). The study aimed to explore relationship between Recent Subcortical Infarct (RSSI) and Blood Pressure Variability (BPV), Heart Rate (HRV).
Abstract The oncomutation lysine 27-to-methionine in histone H3 (H3K27M) is frequently identified tumors of patients with diffuse midline glioma-H3K27 altered (DMG-H3K27a). H3K27M inhibits the deposition mark H3K27me3, which affects maintenance transcriptional programs and cell identity. Cells expressing are also characterized by defects genome integrity, but mechanisms linking expression oncohistone to DNA damage remain mostly unknown. In this study, we demonstrate that H3.1K27M model plant...
Background Cerebral small vessel disease (CSVD) is common in the elderly population. Neutrophil gelatinase-associated lipocalin (NGAL) closely related to cardiovascular and cerebrovascular diseases. NGAL causes pathological changes, such as damage vascular endothelium, by causing inflammation, which results other The purpose of this study was investigate whether serum levels could predict severity patients with CSVD. Methods CSVD who visited Department Neurology at First Affiliated Hospital...
Background.Carotid atherosclerosis (CAS) is one of the main causes ischemic stroke.Currently, clinical evidence for contrast-enhanced ultrasonography (CEUS) as a method diagnosing CAS still inadequate.Sirtuin-3 (SIRT3) associated with inflammation response; however, few studies have evaluated SIRT3 in CAS. Objectives.To investigate role patients and its diagnostic value unstable plaques when combined CEUS.Materials methods.This prospective observational study including 517 who were admitted...
Hawthorn fruit is bright red in color, contains a variety of nutrients, and has many health effects. In this paper, through the study yeast, fermentation temperature, acid reduction, high residual sugar other factors, we finally selected NO303 Aerospace yeast with rich ester aroma low degree reserved bank Qilu University technology for fermentation. Fermentation temperature 19.0℃, main duration is:1-2days, total time about 10 days. The physical chemical indexes alcohol hawthorn beer are as...
Abstract Transformation via Agrobacterium tumefaciens (Agrobacterium) is the predominant method used to introduce exogenous DNA into plants. Transfer (T-DNA) originating from can be integrated as a single copy or in concatenated forms plant genomes, but mechanisms affecting final T-DNA structure remain unknown. In this study, we demonstrate that inclusion of retrotransposon (RT)-derived sequences increase transgene number by more than 50-fold Arabidopsis thaliana (Arabidopsis). RT-mediated...
Lacunae and white matter hyperintensity (WMH) are two crucial imaging biomarkers of cerebral small vessel disease (CSVD). Multiple studies have revealed a close relationship between WMH lacunae found that double penumbra existed at the edge affects formation. The study aimed to explore spatial distribution characteristics possible influencing factors lacuna in relation patients with CSVD.A total 480 CSVD or without were included. Data about blood biochemical indicators, cerebrovascular CT...
1例10月龄女婴因"间断发热、腹泻21 d"入院。患儿生后出现不明原因周期性发热、腹泻，本次并发多处小肠穿孔，行肠穿孔修补术，给予沙利度胺治疗后完全缓解。家系全外显子检测提示患儿为TNFAIP3基因自发杂合无义突变c.133C>T（p.R45X）所致婴儿型炎症性肠病。本病临床罕见。.
Abstract Plants have served as a preeminent study system for photoperiodism because of their propensity to flower in concordance with the seasons. A nearly singular focus on understanding seasonal flowering has been detriment discovering other photoperiod measuring mechanisms that may be necessary vegetative health. Here we use bioinformatics identify group winter photoperiod-induced genes Arabidopsis and show one, PP2-A13 , is critical fitness survival, exclusively winter-like photoperiods....