A5085040882- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Plant Molecular Biology Research
- RNA modifications and cancer
- Cancer-related gene regulation
- Plant Parasitism and Resistance
- Tree Root and Stability Studies
- RNA Interference and Gene Delivery
- HIV Research and Treatment
- Plant Reproductive Biology
Babraham Institute
2022-2024
Wellcome Centre for Cell Biology
2022-2024
University of Edinburgh
2022-2024
Indian Institute of Science Education and Research Thiruvananthapuram
2020
Indian Institute of Science Education and Research Berhampur
2019
Indian Institute of Science Education and Research Mohali
2019
Indian Institute of Science Education and Research Kolkata
2019
Indian Institute of Science Education and Research, Bhopal
2019
Indian Institute of Science Education and Research, Tirupati
2019
The tail of replication-dependent histone H3.1 varies from that replication-independent H3.3 at the amino acid located position 31 in plants and animals, but no function has been assigned to this residue demonstrate a unique conserved role for during replication. We found TONSOKU (TSK/TONSL), which rescues broken replication forks, specifically interacts with via recognition alanine by its tetratricopeptide repeat domain. Our results indicate genomic instability absence ATXR5/ATXR6-catalyzed...
Aerial organs of plants, being highly prone to local injuries, require tissue restoration ensure their survival. However, knowledge the underlying mechanism is sparse. In this study, we mimicked natural injuries in growing leaves and stems study reunion between mechanically disconnected tissues. We show that
The PIWI-interacting RNA (piRNA) pathway guides the DNA methylation of young, active transposons during germline development in male mice
Promoters of developmental genes in embryonic stem cells (ESCs) are marked by histone H3 lysine 4 trimethylation (H3K4me3) and H3K27me3 an asymmetric nucleosomal conformation, with each sister carrying only one the two marks. These bivalent domains thought to poise for timely activation upon differentiation. Here, we show that nucleosomes recruit repressive binders but fail enrich activating H3K4me3 binders, thereby promoting a poised state. Strikingly, mark combination further promotes...
Abstract The oncomutation lysine 27-to-methionine in histone H3 (H3K27M) is frequently identified tumors of patients with diffuse midline glioma-H3K27 altered (DMG-H3K27a). H3K27M inhibits the deposition mark H3K27me3, which affects maintenance transcriptional programs and cell identity. Cells expressing are also characterized by defects genome integrity, but mechanisms linking expression oncohistone to DNA damage remain mostly unknown. In this study, we demonstrate that H3.1K27M model plant...
Abstract DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining methylation patterns. However, the mechanisms underlying DNMT3A recruitment to function within different chromatin environments remain unclear. Using combination of biochemical structural approaches we find that interacts using multiple interfaces with chromatin; directly binding generic nucleosome features as well site-specific post-translational histone modifications. The N-terminal region,...
Plants can repair wounds throughout their body when they suffer injuries. The molecular mechanisms underlying this universal regeneration potential, and how regulation of tissue compares with its formation during development, remains unknown. Here, we reveal an essential role for members the PLETHORA(PLT)/ AINTEGUMENTA(ANT) gene family in activating innate responses to injuries form that growing aerial parts plant naturally encounter. Strikingly, PLT act through embryonic symmetry...