A5101581780- Inflammatory Bowel Disease
- Neonatal and fetal brain pathology
- Digestive system and related health
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Congenital gastrointestinal and neural anomalies
- Mast cells and histamine
- Asthma and respiratory diseases
- Microscopic Colitis
- Anesthesia and Neurotoxicity Research
- Gut microbiota and health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Mycobacterium research and diagnosis
- Genetic factors in colorectal cancer
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Nutrition and Health in Aging
- Signaling Pathways in Disease
- Protein Tyrosine Phosphatases
- Cardiac Ischemia and Reperfusion
Children's Hospital of Fudan University
2011-2023
Second Affiliated Hospital of Zhejiang University
2020
Orthopaedic Center
2020
Boston Children's Hospital
2015
Fudan University
2013
Third Affiliated Hospital of Zhengzhou University
2007
Upon cerebral hypoxia-ischemia (HI), apoptosis-inducing factor (AIF) can move from mitochondria to nuclei, participate in chromatinolysis, and contribute the execution of cell death. Previous work (Cande, C., N. Vahsen, I. Kouranti, E. Schmitt, Daugas, C. Spahr, J. Luban, R.T. Kroemer, F. Giordanetto, Garrido, et al. 2004. Oncogene. 23:1514–1521) performed vitro suggests that AIF must interact with cyclophilin A (CypA) form a proapoptotic DNA degradation complex. We addressed question as...
Background: Interleukin-10 (IL10) signaling plays an important role in the pathogenesis of very early onset inflammatory bowel disease (VEO-IBD) children.However, little is known about IL10 axis children with VEO-IBD China. Methods:The Chinese Collaboration Group was created to collect clinical and genetic data from patients deficient receptor.High-throughput sequencing performed identify mutations these genes. Results:We identified 32 compound heterozygous 9 homozygous receptor subunit...
Interleukin-10 (IL10)/interleukin-10 receptor (IL10R) deficiency is a rare disease with life-threatening infantile-onset colitis. We sought to accurately phenotype this disorder based on large cohort of patients proven defect IL10 signaling and clarify the effects allogeneic hematopoietic stem cell transplantation (HSCT).We analyzed phenotypes our 61 reviewed 78 other previously reported cases identified mutations in genes encoding or IL10R. also compared clinical features interleukin-10 B...
Achalasia is a disease caused by neuromuscular dysfunction in the esophagogastric junction, with relatively low incidence among children. Peroral endoscopic myotomy (POEM) new procedure for treatment of achalasia; however, it rarely applied children.We aim to study feasibility, safety, and effectiveness POEM as pediatric achalasia.A total 21 patients (ages from 11 months 18 years) diagnosed having achalasia treated October 2014 2016 our hospital were included study. Indices such clinical...
Mutations in tumor necrosis factor alpha-induced protein 3 (TNFAIP3), a key player the negative feedback regulation of nuclear factor-κB signaling, have recently been recognized as leading to early onset autoinflammatory and autoimmune syndrome. Here, we reported phenotypes infantile intractable inflammatory bowel disease (IBD) patients with TNFAIP3 mutations reviewed previously cases establish phenotypic features associated monogenicity.From January 1, 2015, December 31, 2017, recruited 58...
Hematopoietic stem cell transplantation is considered the only curative therapy for very early-onset inflammatory bowel disease with specific immune defects, such as interleukin-10 receptor deficiency. We performed reduced-intensity conditioning before umbilical cord blood in patients receptor-A enrolled 9 typical manifestations. diagnosed deficiency by whole-exome sequencing. Umbilical was all patients. Eight received regimen, and 1 patient myeloablative regimen. All between ages of 6...
Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disease characterized by gastrointestinal hamartomatous polyps and mucocutaneous melanin spots. Germline mutation of the serine/threonine kinase 11 (STK11) gene are responsible for PJS. In this study, we investigated clinical characteristics molecular basis in Chinese children with Thirteen diagnosed PJS our hospital were enrolled study from 2011 to 2015, their data on polyp characteristics, intussusceptions events, family...
Abstract Background We previously reported that the administration of 14‐day standard triple therapy (TT), sequential (ST), bismuth‐based quadruple (BT), and concomitant (CT) as first‐line for Helicobacter pylori infection in Chinese children achieved eradication rates 74.1%, 69.5%, 89.8%, 84.6%, respectively. In this follow‐up study, we further evaluated short‐ long‐term effects four regimens on gut microbiota these children. Methods prospectively recruited treatment‐naïve with H....
The immature brain is susceptible to inflammatory injury induced by hypoxia-ischemia (HI) or infection, which causes serious neurodevelopmental disabilities in the survivors of preterm births. Recently, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors (death receptor DR4/5 decoy DcR1/2) were reported mediate various neuroinflammatory responses. However, little information available regarding role TRAIL after HI. purpose this study was evaluate expression HI...
Several studies have employed animal models to explore the association between microbiota and interleukin (IL) 10 signaling; however, limited information is available about human microbiome.To characterize microbiome in patients with IL10RA mutations gut dysbiosis disease severity.Fecal samples were collected from who diagnosed loss-of-function gene January 2017 July 2018 at Children's Hospital of Fudan University. Age-matched volunteer children recruited as healthy controls. Patients...
Giant peptic ulcers (GPUs) are detrimental for all patients, especially children. However, few reports have described GPUs in This study aims to evaluate the characteristics of Chinese children and identify risk factors.We retrospectively analyzed patients at Children's Hospital Fudan University from April 2014 August 2017. Patients with (>2.0 cm) were included study, clinical data, pathological presence Helicobacter pylori (H. pylori) infection outcomes.A total 19208 underwent gastroscopic...
Video capsule endoscopy (VCE) can detect mucosal lesions in the intestine, especially small bowel.Our study aims to evaluate applications of VCE for pediatric gastrointestinal diseases.In this retrospective study, we included all patients who underwent between December 2012 and 2018. Clinical information data were analyzed.Among 828 patients, completion rate was 99.6% (n = 825), with an average age 10.2 ± 3.3 years old. A total 459 procedures showed abnormalities, overall diagnostic yield...
AIM:To investigate multiple polyps in a Chinese Peutz-Jeghers syndrome (PJS) infant. METHODS:A nine-month-old PJS infant was admitted to our hospital for recurrent prolapsed rectal one month.The clinical characteristics, colonoscopic image, the pathological characteristics of and X-ray images intestinal perforation were obtained.Serine threonine-protein kinase 11 (STK11 ) gene analysis also performed using DNA sample from this RESULTS:Here we describe youngest known with PJS.Five polyps,...
Interleukin-10 (IL10) signalling pathway deficiency results in severe very early onset inflammatory bowel disease (VEOIBD), and enterostomy is often inevitable. However, studies these surgical populations are lacking. This study aims to determine the characteristics, postoperative complications related risk factors patients.From March 1, 2015, December 31, 2018, patients with IL10R-mutation who underwent were recruited for analysis. We collected data on patients' clinical factors.Twelve...
Background: Meckel’s diverticulum (MD) is the most common congenital anomaly of gastrointestinal tract and also an important cause bloody stool anemia in children. However, there are few data about video capsule endoscopy (VCE) for MD This study aimed to evaluate diagnostic value VCE Materials methods: children who underwent obscure bleeding from October 1st 2015 August 31st 2019 at Children’s Hospital Fudan University were included this retrospective study. Medical data, scans, etc....
Background: Cytomegalovirus (CMV) is rarely thought to be the cause of significant gastrointestinal infection in immunocompetent children. CMV colitis seldom observed young infants. This study aims examine clinical features Chinese children.Methods: Patients with infantile onset diagnosed intestinal tissue at Children’s Hospital Fudan University from 1st January 2017, 31st 2019 were enrolled. Clinical data retrieved medical records, and literature on infant was also reviewed.Results: Ten...
Abstract Background Defects in interleukin 10 (IL10) and its receptors are particularly involved very early onset inflammatory bowel disease (VEOIBD). However, large fragment deletions of IL10 receptor A ( IL10RA ) rare. Methods VEOIBD patients with confirmed mutations the gene were enrolled from January 1, 2019 to June 30, 2020. The clinical features endoscopic-radiological findings determined followed up. Results Thirty-five mutations, namely, 28 compound heterozygous 7 homozygote this...
Very early-onset inflammatory bowel disease (VEOIBD) with interleukin-10 (IL10R) signaling deficiency usually requires enterostomy in patients who are refractory to traditional treatment. This study aimed evaluate long-term outcomes after for VEOIBD IL10R deficiency.The medical records of all undergoing were retrospectively assessed during 2012.1-2022.7 a tertiary teaching hospital, Children's Hospital Fudan University, Shanghai, China. Data on history, diagnosis and details stoma closure...
Umbilical cord blood transplantation (UCBT) is associated with a relatively high rate of engraftment failure. This study aimed at exploring whether any fecal microbiota could be failure following UCBT in Crohn's disease patients IL10RA deficiency.Thirteen were recruited and their 230 samples collected longitudinally from immediately before conditioning chemotherapy to 8 weeks post the UCBT. The V3-V4 regions bacterial 16S rRNA gene amplified by PCR sequenced, followed bioinformatics...