A5056180081- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Plant Virus Research Studies
- Signaling Pathways in Disease
- DNA Repair Mechanisms
- Virus-based gene therapy research
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Plant-Microbe Interactions and Immunity
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Immune cells in cancer
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Plant tissue culture and regeneration
- Fungal and yeast genetics research
- FOXO transcription factor regulation
- Cancer Immunotherapy and Biomarkers
- Genomics and Chromatin Dynamics
Université Paris-Saclay
2009-2024
Institut Gustave Roussy
2011-2022
Centre National de la Recherche Scientifique
1985-2022
Centre Hospitalier de Luxembourg
2021
Ospedale San Giuseppe
2021
Luxembourg Institute of Health
2021
University of Luxembourg
2021
Inserm
2007-2018
Université Paris-Sud
2008-2017
Centre de Recherche des Cordeliers
2015
Cardiac glycosides kill cancer cells in a way that stimulates the immune response.
p300 and the CREB-binding protein CBP are two large nuclear phosphoproteins that structurally highly related. Both function, in part, as transcriptional adapters targeted by adenovirus E1A oncoprotein. We show here interact with another transforming protein, simian virus 40 T antigen (T). This interaction depends on integrity of a region which is critical for its mitogenic properties includes LXCXE Rb-binding motif. interferes normal function at least different levels. The presence alters...
Upon cerebral hypoxia-ischemia (HI), apoptosis-inducing factor (AIF) can move from mitochondria to nuclei, participate in chromatinolysis, and contribute the execution of cell death. Previous work (Cande, C., N. Vahsen, I. Kouranti, E. Schmitt, Daugas, C. Spahr, J. Luban, R.T. Kroemer, F. Giordanetto, Garrido, et al. 2004. Oncogene. 23:1514–1521) performed vitro suggests that AIF must interact with cyclophilin A (CypA) form a proapoptotic DNA degradation complex. We addressed question as...
Extracellular adenosine triphosphate (ATP) can activate purinergic receptors of the plasma membrane and modulate multiple cellular functions. We report that ATP is released from HIV-1 target cells through pannexin-1 channels upon interaction between envelope protein specific cell receptors. then acts on receptors, including P2Y2, to proline-rich tyrosine kinase 2 (Pyk2) transient depolarization, which in turn stimulate fusion Env-expressing membranes containing CD4 plus appropriate chemokine...
Cancer is a major and still increasing cause of death in humans. Most cancer cells have fundamentally different metabolic profile from that normal tissue. This shift away mitochondrial ATP synthesis via oxidative phosphorylation towards high rate glycolysis, termed Warburg effect, has long been recognized as paradigmatic hallmark cancer, supporting the increased biosynthetic demands tumor cells. Here we show deletion apoptosis-inducing factor (AIF) KrasG12D-driven mouse lung model resulted...
Human CHCHD4 is the prototype of proteins carrying a coiled-coil-helix-coiled-coil-helix motif that stabilized by two disulfide bonds. Using its CPC sequence motif, plays key role in mitochondrial metabolism, cell survival, and response to stress conditions controlling import diversified protein substrates are specifically recognized through an interplay between covalent non-covalent interactions. In present review, we provide updated comprehensive analysis controlled redox activities. A...
Several cellular polypeptides critical for growth regulation interact with DNA tumor virus oncoproteins. p400 is a protein which binds to the adenovirus E1A oncoprotein(s). The biological function of not yet known, but it structurally and immunologically closely related p300 CREB-binding protein, two known E1A-binding transcription adapters. Like p300, phosphoprotein that simian 40 large antigen (T). In anti-T coimmunoprecipitation experiments, staggered deletions spanning amino-terminal 250...
Abstract Even though cell death modalities elicited by anticancer chemotherapy and radiotherapy have been extensively studied, the ability of treatments to induce non-cell-autonomous has never investigated. By means multispectral imaging flow-cytometry-based technology, we analyzed lethal fate cancer cells that were treated with conventional agents co-cultured untreated cells, observing can simultaneously trigger cell-autonomous in cells. After ionizing radiation, oxaliplatin, or cisplatin...