A5023675403- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Neuroscience and Neuropharmacology Research
- Signaling Pathways in Disease
- Toxoplasma gondii Research Studies
- Coenzyme Q10 studies and effects
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Bioactive Compounds and Antitumor Agents
- NF-κB Signaling Pathways
- Vitamin C and Antioxidants Research
- Genetic Neurodegenerative Diseases
- Cell Image Analysis Techniques
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Photoreceptor and optogenetics research
- Phagocytosis and Immune Regulation
- Trace Elements in Health
Centre National de la Recherche Scientifique
2015-2020
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2020
Université Paris-Sud
2008-2020
Université Paris-Saclay
2010-2020
Institut Interdisciplinaire de Neuroscience
2018
Université de Bordeaux
2018
Inserm
2008-2016
Institut Gustave Roussy
2008-2016
Centre de Recherche des Cordeliers
2015-2016
Weatherford College
2015
Regulation of AMPA receptor (AMPAR) trafficking is a key modulator excitatory synaptic transmission; however, intracellular vesicular transport newly synthesized AMPARs has been little studied due to technical limitations. By combining molecular tools with imaging strategies in cultured rat hippocampal neurons, we found that vesicles containing synthesized, GluA1-subunit-containing are transported antero- and retrogradely at mean speed 1.5 μm.s−1. Synaptic activity variations calcium levels...
// Hesti Lina Wiraswati 1,2,3,4,5 , Emilie Hangen 1,2,3,4 Ana Belén Sanz 1,2,3,4,6 Ngoc-Vy Lam Camille Reinhardt 3,4,7 Allan Sauvat 1,2,3,8 Ariane Mogha Alberto Ortiz 6 Guido Kroemer 1,2,3,8,9,10,11,12,* and Nazanine Modjtahedi 3,4,7,* 1 Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France 2 INSERM, U1138, 3 Gustave Roussy Cancer Campus, Villejuif, 4 Faculty of Medicine, Université Paris-Saclay, Kremlin-Bicêtre, 5...
Hypomorphic mutation of apoptosis-inducing factor (AIF) in the whole body or organ-specific knockout AIF compromises activity respiratory chain complexes I and IV, as it confers resistance to obesity diabetes induced by high-fat diet. The mitochondrial defect deficiency can be explained reduced AIF-dependent import CHCHD4, which turn is required for optimal assembly complexes. Here we show that, compared wild type control littermates, mice with a heterozygous CHCHD4 exhibit weight gain when...
In many models of programmed cell death, the mitochondrial protein AIF translocates to nucleus, where it induces chromatin condensation and DNA degradation. However, today is well established that this flavoprotein bifunctional. addition its lethal function in nucleus dying cells, plays a vital bioenergetic role healthy ones by regulating mainly activity respiratory chain complex I. Hypomorphic or deletion mutants have led generation first reliable mouse model I deficiency syndrome, which...