A5101934516- Advanced Causal Inference Techniques
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Bowel Disease
- Behavioral Health and Interventions
- Microscopic Colitis
- Impact of Technology on Adolescents
- Mental Health Research Topics
- Statistical Methods and Bayesian Inference
- Metabolism and Genetic Disorders
- Helicobacter pylori-related gastroenterology studies
- Mobile Health and mHealth Applications
- Immune Response and Inflammation
- Social Media and Politics
- Nutrition and Health in Aging
- HER2/EGFR in Cancer Research
- Diet and metabolism studies
- Biochemical and Molecular Research
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Cancer Research and Treatments
- Genomics and Rare Diseases
- Gastrointestinal motility and disorders
- Multiple Myeloma Research and Treatments
- Neurogenetic and Muscular Disorders Research
- Health, Environment, Cognitive Aging
Children's Hospital of Fudan University
2016-2025
University of Michigan
2022-2023
Shandong Normal University
2018
Shanxi Medical University
2016
Boston Children's Hospital
2015
Using the Internet has become one of most popular leisure activities among postsecondary students in China. Concern about large number using led to an increase research on influencing factors addiction and negative consequences caused by it. This short-term longitudinal study examined associations three dimensions social support [objective (OS), subjective (SS), utilization (SU)], loneliness, four (compulsive use [CIU] & withdrawal from [WIA], tolerance [TIA], time-management problems...
Pancreatic cancer is a highly lethal malignancy and one of the leading causes cancer-related death. During development progression cancer, tumor angiogenesis plays crucial role. A great deal evidence has revealed that human mast cells (MCs) contributed to through releasing several pro-angiogenetic factors, among which tryptase most active. However, role cell (MCT) in pancreatic still not well documented. In this study, we examined MCT levels serum from patients evaluated correlationship...
Interleukin-10 (IL10)/interleukin-10 receptor (IL10R) deficiency is a rare disease with life-threatening infantile-onset colitis. We sought to accurately phenotype this disorder based on large cohort of patients proven defect IL10 signaling and clarify the effects allogeneic hematopoietic stem cell transplantation (HSCT).We analyzed phenotypes our 61 reviewed 78 other previously reported cases identified mutations in genes encoding or IL10R. also compared clinical features interleukin-10 B...
<title>Abstract</title> Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key regulator of apoptosis, necroptosis, and inflammation. Over the last decades, function RIPK1 has been extensively studied in mouse models. But phenotype associated with deficiency humans was unknown until 2018. Pathogenic variants have described as cause two different inborn errors immunity. Beyond biallelic loss-of-function mutations primary immunodeficiency very early-onset inflammatory bowel...
Abstract Mobile health (mHealth) interventions may enhance positive behaviors, but randomized trials evaluating their efficacy are uncommon. Our goal was to determine if a mHealth intervention augmented and extended benefits of center-based cardiac rehabilitation (CR) for physical activity levels at 6-months. We delivered clinical trial low moderate risk patients with compatible smartphone enrolled in CR two systems. All participants received smartwatch usual care. Intervention that included...
Abstract Background The aim of this study was to prospectively the effect exclusive enteral nutrition (EEN) treatment on Chinese pediatric Crohn's disease (CD) patients. Methods Thirty‐one newly diagnosed CD patients were enrolled in and treated with EEN for 8 weeks. Twelve healthy controls (HCs) donated their fecal samples. Statistical methods used compare differences. Results According Simple Endoscopic Score (SES‐CD) at end treatment, 21 SES‐CD ≤4 classified into remission group (CD‐RE),...
Abstract Background We previously reported that the administration of 14‐day standard triple therapy (TT), sequential (ST), bismuth‐based quadruple (BT), and concomitant (CT) as first‐line for Helicobacter pylori infection in Chinese children achieved eradication rates 74.1%, 69.5%, 89.8%, 84.6%, respectively. In this follow‐up study, we further evaluated short‐ long‐term effects four regimens on gut microbiota these children. Methods prospectively recruited treatment‐naïve with H....
Giant peptic ulcers (GPUs) are detrimental for all patients, especially children. However, few reports have described GPUs in This study aims to evaluate the characteristics of Chinese children and identify risk factors.We retrospectively analyzed patients at Children's Hospital Fudan University from April 2014 August 2017. Patients with (>2.0 cm) were included study, clinical data, pathological presence Helicobacter pylori (H. pylori) infection outcomes.A total 19208 underwent gastroscopic...
To examine the role of A20 in regulation intestinal epithelial cells (IECs) inflammation.Using gene transfection, both stable overexpression and knockdown A20-expressed HT-29 cell lines were established. Accordingly, divided into following groups: The control group, group respective controls. was stimulated with lipopolysaccharide (LPS) a dose- time-dependent manner detected using western blotting real-time polymerase chain reaction (PCR) analyses. Immunofluorescence analyses performed to...
Twin revolutions in wearable technologies and smartphone-delivered digital health interventions have significantly expanded the accessibility uptake of mobile (mHealth) across various science domains. Sequentially randomized experiments called micro-randomized trials (MRTs) grown popularity to empirically evaluate effectiveness these mHealth intervention components. MRTs given rise a new class causal estimands known as "causal excursion effects", which enable scientists assess how changes...
The use of smart devices (e.g., smartphones, smartwatches) and other wearables for context sensing delivery digital interventions to improve health outcomes has grown significantly in behavioral psychiatric studies. Micro-randomized trials (MRTs) are a common experimental design obtaining data-driven evidence on mobile (mHealth) intervention effectiveness where each individual is repeatedly randomized receive treatments over numerous time points. Individual characteristics the contexts...
Umbilical cord blood transplantation (UCBT) is associated with a relatively high rate of engraftment failure. This study aimed at exploring whether any fecal microbiota could be failure following UCBT in Crohn's disease patients IL10RA deficiency.Thirteen were recruited and their 230 samples collected longitudinally from immediately before conditioning chemotherapy to 8 weeks post the UCBT. The V3-V4 regions bacterial 16S rRNA gene amplified by PCR sequenced, followed bioinformatics...
Potential protein–phenotype correlation in three lipopolysaccharide-responsive beige-like anchor protein-deficient patients
We previously found text messages (TM) delivered as part of a comprehensive mobile health intervention may augment physical activity levels in patients enrolled cardiac rehabilitation (CR) during its initiation phase, although optimal TM tailoring is unknown.
A common approach to learning mobile health (mHealth) intervention policies is linear Thompson sampling. Two desirable mHealth policy features are (1) pooling information across individuals and time (2) incorporating a time-varying baseline reward. Previous approaches pooled but not time, failing capture trends in treatment effects over time. In addition, these did explicitly model the reward, which limited ability precisely estimate parameters differential reward model. this paper, we...
Abstract Background Multiple acyl-CoA dehydrogenation deficiency (MADD) is an inborn error of metabolism in fatty acid oxidation. We described unusual case recurrent vomiting and abdominal pain a child with MADD, presenting velvet-like changes the small intestine. Methods Because prominent gastrointestinal manifestations intestine ulcers, patient was first diagnosed as Crohn’s disease. The admitted to our institution because symptoms despite treatment. Upper lower endoscopy, computed...
The micro-randomized trial (MRT) is a sequential randomized experimental design to empirically evaluate the effectiveness of mobile health (mHealth) intervention components that may be delivered at hundreds or thousands decision points. MRTs have motivated new class causal estimands, termed "causal excursion effects", for which semiparametric inference can conducted via weighted, centered least squares criterion (Boruvka et al., 2018). Existing methods assume between-subject independence and...
Construction of just-in-time adaptive interventions, such as prompts delivered by mobile apps to promote and maintain behavioral change, requires knowledge about time-varying moderated effects inform when how we deliver intervention options. Micro-randomized trials (MRT) have emerged a sequentially randomized design gather requisite data for effect estimation. The existing literature (Qian et al., 2020; Boruvka 2018; Dempsey 2020) has defined general class causal estimands, referred "causal...
Abstract: Multiple acyl-CoA dehydrogenase deficiency (MADD) is an inborn error of metabolism in fatty acid oxidation. We described unusual case recurrent vomiting and abdominal pain a child with MADD, presenting velvet-like changes the small intestine. Because prominent gastrointestinal manifestations intestine ulcers, patient was first diagnosed as Crohn’s disease. The admitted to our institution because symptoms despite treatment. Upper lower endoscopy, computed tomography trios exome...
The micro-randomized trial (MRT) is a sequential randomized experimental design to empirically evaluate the effectiveness of mobile health (mHealth) intervention components that may be delivered at hundreds or thousands decision points. MRTs have motivated new class causal estimands, termed "causal excursion effects", for which semiparametric inference can conducted via weighted, centered least squares criterion (Boruvka et al., 2018). Existing methods assume between-subject independence and...