Mesenchymal stem cell therapy is a novel regenerative approach for treating tendinopathy. Here, we evaluated the safety and efficacy of allogeneic adipose-derived mesenchymal cells (allo-ASC) in lateral epicondylosis (LE). Under ultrasound guidance, allo-ASCs mixed with fibrin glue were injected into hypoechoic common extensor tendon lesions 12 participants chronic LE; 6 subjects each administered 10(6) or 10(7) 1 ml. Safety was at day 3 weeks 2, 6, 12, 26, 52 post-injection. Efficacy...

Range of motion (ROM) measurements are essential for the evaluation and diagnosis adhesive capsulitis shoulder (AC). However, taking these using a goniometer is inconvenient sometimes unreliable. The Kinect (Microsoft, Seattle, WA, USA) gaining attention as new detecting device that nonintrusive easy to implement. This study aimed apply measure ROM in AC; we evaluated its validity by calculating agreement obtained with those assessed utility AC. Both shoulders 15 healthy volunteers affected...

An intelligent stretching device was developed to treat the spastic/contractured ankle of neurologically impaired patients. The stretched safely throughout range motion (ROM) extreme dorsiflexion and plantarflexion until a specified peak resistance torque reached with velocity controlled based on torque. held at position for period time let stress relaxation occur before it rotated back other position. Stretching slow joint positions, making possible reach larger ROM fast in middle so...

Background: Although survival of transplanted stem cells in vivo and differentiation into tenocytes vitro have been reported, there no studies demonstrating that mesenchymal (MSCs) could secrete their own proteins as differentiated tenogenic cells. Purpose/Hypothesis: Using a xenogeneic MSC transplantation model, we aimed to investigate whether MSCs differentiate the lineage proteins. The hypothesis was human would be able human-specific rat tendon injury model. Study Design: Controlled...

Abstract Sarcopenia is a gradual loss of skeletal muscle mass and function with aging. Given that sarcopenia has been recognized as disease entity, effective molecular biomarkers for early diagnosis are required. We recruited 46 normal subjects 50 patients moderate aged 60 years older. was clinically identified on the basis appendicular index by applying cutoff values derived from Asian Working Group Sarcopenia. The serum levels 21 potential were analyzed statistically examined. Interleukin...

Tendons have limited reparative ability and perform a relatively simple mechanical function via the extracellular matrix. Thus, injured tendon might be treated successfully by stem cell transplantation. We performed randomized, controlled study to investigate effects of mesenchymal injection for treating partial tears in supraspinatus tendon. enrolled 24 patients with shoulder pain lasting more than 3 months Participants were assigned three groups: cells fibrin glue, normal saline/fibrin...

<i>Background:</i> The age-related effects on various aspects of swallowing have been reported in studies the temporal relationship between hyolaryngeal movement and bolus location, as well extent movement. However, few described spatial relationships concurrently. <i>Objective:</i> main purpose this study was to define kinematics hyoid bone epiglottis, during swallowing, concurrently healthy subjects, investigate influence aging <i>Methods:</i> We...

Objectives It has been reported that low skeletal muscle mass correlates with knee osteoarthritis in obese individuals. This study aimed to investigate whether lower limb is independently associated the general population. Materials and Methods cross-sectional used public data from Fourth Fifth Korean National Health Nutrition Examination Survey. Subjects included 4924 community-dwelling adults aged ≥50 years (821 subjects 4,103 controls). Skeletal index (SMI) was calculated appendicular...

Abstract This study aimed to compare the long-term effects of flexion- and extension-based lumbar exercises on chronic axial low back pain (LBP). was a 1-year follow-up prospective, assessor-blind, randomized controlled trial. Patients with LBP (intensity ≥ 5/10) for > 6 months allocated flexion or extension exercise group. underwent four sessions supervised treatment program were required perform their assigned daily at home. Clinical outcomes obtained baseline, 1, 3, months, 1-year. A...

The widespread use of mobile devices and desktop computers has been associated with mechanical neck symptoms, yet few studies have compared cervical kinematics clinical symptoms between them. In this study, 15 participants (27.7 ± 4.4 years, 12 male) performed four randomly ordered 20 min tasks: two (smartphone tablet) computer (keyboard mouse) tasks. Kinematic variables, including flexion, lateral bending, axial rotation, anterior translation, total distance moved, were measured using an...

Tightening and contracture of the joint capsule are hallmarks adhesive capsulitis shoulder (ACS). However, quantification capsular stiffness its relation to clinical features have not been investigated thoroughly.To quantify during intra-articular hydraulic distension (IHD) investigate relationships with pain severity, symptom duration, range motion (ROM), gender, diabetes status.Case series.University outpatient clinic physical medicine rehabilitation.A total 107 consecutive patients ACS...

To evaluate at which pH level various local anesthetics precipitate, and to confirm combination of corticosteroid anesthetic crystallizes.Each ropivacaine-HCl, bupivacaine-HCl, lidocaine-HCl was mixed with 4 different concentrations NaOH solutions. Also, each the three same volume 3 solutions (triamcinolone acetonide, dexamethasone sodium phosphate, betamethasone phosphate). Precipitation (or not) observed, by naked eye microscope. The solution size precipitated crystal were...

Abstract The effect of intraarticular hydraulic distension (IHD) for a painful stiff shoulder (or adhesive capsulitis) has been affirmed, but whether rupturing the joint capsule during this process is beneficial remains controversial. By monitoring real‐time pressure–volume (PV) profiles IHD, we could infuse largest possible volume without capsule. Using novel technique, compared short‐term effects IHD when was preserved versus it ruptured. Fifty‐four patients with underwent IHDs intended to...

Objectives To examine the association between type and amount of physical activity (PA) low back pain (LBP) in people aged ≥50 years. Design Cross‐sectional study. Setting A nationwide survey. Participants Data were obtained from Fifth Korea National Health Nutrition Examination Survey, which was conducted 2010 2011. Overall, 1796 men 2198 women years included. Methods PA categorized as vigorous, moderate, walking, strength exercises, or flexibility exercises. The total presented quartiles...

Glucocorticoids play a major role in the development of muscle atrophy various medical conditions, such as cancer, burn injury, and sepsis, by inhibiting insulin signaling. In this study, we report new pathway which glucocorticoids reduce levels upstream signaling components downregulating transcription gene encoding caveolin-1 (CAV1), scaffolding protein present caveolar membrane. Treatment with glucocorticoid dexamethasone (DEX) decreased CAV1 Cav1 mRNA expression, concomitant reduction...

Objective: Loss of skeletal muscle mass is known to be associated with multiple morbidities. However, there a dearth reports on its association lumbar lordosis and musculoskeletal pain. The aim this study was delineate the cross-sectional relationship between loss mass, lordosis, chronic low back pain (CLBP).Methods: A total 721 medical records were reviewed, data from 165 older subjects (over 65 years old; 81 men 84 women) retrospectively analyzed. Subjects categorized into either CLBP...

Mirror therapy has been performed as effective occupational in a clinical setting for functional recovery of hemiplegic arm after stroke. It is conducted by eliciting an illusion through use mirror if the moving real-time while healthy arm. can facilitate brain neuroplasticity activation sensorimotor cortex. However, conventional critical limitation that not actually moving. Thus, we developed 2-axis robot system simple add-on module using closed feedback mechanism, which enables movement We...

Various therapeutic effects of mesenchymal stem cells (MSCs) have been reported. However, the rapid clearance these in vivo, difficulties identifying their mechanism action, and insufficient production levels remain to be resolved. We investigated whether a pioglitazone pre-treatment MSCs (Pio-MSCs) would stimulate proliferation co-cultured tenocytes. Pioglitazone increased enhanced secretion VEGF (vascular endothelial growth factor) collagen cells. then examined Pio-MSCs on tenocytes using...