A5047745475- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Hypoxia, and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- S100 Proteins and Annexins
- Angiogenesis and VEGF in Cancer
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Cardiovascular Health and Disease Prevention
- Atherosclerosis and Cardiovascular Diseases
- Sodium Intake and Health
- Mesenchymal stem cell research
- Cerebrovascular and Carotid Artery Diseases
- Muscle metabolism and nutrition
- GDF15 and Related Biomarkers
- Protein Tyrosine Phosphatases
- Liver Disease Diagnosis and Treatment
Yanbian University Hospital
2016-2023
Nagoya University
2016-2022
GTx (United States)
2022
American College of Cardiology
2017
Abstract Background Exercise train (ET) stimulates muscle response in pathological conditions, including aging. The molecular mechanisms by which exercise improves impaired adiponectin/adiponectin receptor 1 (AdipoR1)‐related actions associated with aging are poorly understood. Here we observed that a senescence‐accelerated mouse prone 10 (SAMP10) model, long‐term ET modulated muscle‐regenerative actions. Methods 25‐week‐old male SAMP10 mice were randomly assigned to the control and (45...
Abstract Background Skeletal muscle mass and function losses in aging individuals are associated with quality of life deterioration disability. Mesenchymal stromal cells exert immunomodulatory anti-inflammatory effects could yield beneficial aging-related degenerative disease. Methods results We investigated the efficacy umbilical cord-derived mesenchymal (UC-MSCs) on sarcopenia-related skeletal atrophy dysfunction senescence-accelerated mouse prone 10 (SAMP10) mice. randomly assigned...
Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular aging and regeneration. Given that dipeptidyl peptidase-4 (DPP4) regulates several intracellular signaling pathways associated with the glucagon-like peptide-1 (GLP-1) metabolism, we investigated role of DPP4/GLP-1 axis in senescence ischemia-induced neovascularization mice under chronic stress, special focus on adiponectin -mediated peroxisome proliferator activated receptor-γ/its co-activator 1α...
Exposure to chronic psychological stress is a risk factor for metabolic cardiovascular disease. Given the important role of lysosomal CTSS (cathepsin S) in human pathobiology, we examined stress-related thrombosis, focusing on inflammation, oxidative stress, and apoptosis.Six-week-old wild-type mice (CTSS+/+) CTSS-deficient (CTSS-/-) randomly assigned nonstress 2-week immobilization groups underwent iron chloride3 (FeCl3)-induced carotid thrombosis surgery morphological biochemical...
Chronic psychological stress is a risk factor for kidney disease, including dysfunction and hypertension. Lysosomal CatK (cathepsin K) participates in various human pathobiologies. We investigated the role of remodeling hypertension response to 5/6 nephrectomy injury mice with or without chronic stress.Male 7-week-old WT (wild type; CatK+/+) CatK-deficient (CatK-/-) that were not subjected underwent nephrectomy. At 8 weeks post-stress/surgery, was observed have accelerated injury-induced...
Abstract Exposure to chronic psychological stress (CPS) is an intractable risk factor for inflammatory and metabolic diseases. Lysosomal cysteinyl cathepsins play important role in human pathobiology. Given that cathepsin S (CTSS) upregulated the stressed vascular adipose tissues, we investigated whether CTSS participates stress-induced skeletal muscle mass loss dysfunction, with a special focus on protein imbalance apoptosis. Eight-week-old male wildtype (CTSS +/+ ) CTSS-knockout −/− mice...
Dipeptidyl peptidase-4 (DPP4) is one of the most potent mammalian serine proteases participated in pathogenesis subclinical atherosclerosis. Here we investigated whether plasma soluble form DPP4 associated with prevalence coronary artery disease (CAD) and without diabetes mellitus (DM). A cross-sectional study was conducted 496 aged 26-81 years (n = 362) 134) CAD. Plasma activity, high sensitive C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C), high-density levels...
The mechanism by which angiogenesis declines with aging is not fully understood. Soluble vascular endothelial growth factor receptor 1 (VEGFR1) form (sFlt1) contributes to dysfunction in pathological conditions. However, the roles of sFlt1 ischemia-induced neovascularizationof aged animals have been investigated. To study aging-related change and its impact on neovascularization, a hindlimb ischemia model was applied young mice. Blood flow imaging assay revealed that blood recovery remained...
Abstract Background Young bone marrow transplantation (YBMT) has been shown to stimulate vascular regeneration in pathological conditions, including ageing. Here, we investigated the benefits and mechanisms of preventive effects YBMT on loss muscle mass function a senescence‐associated mouse prone 10 (SAMP10) model, with special focus role growth differentiation factor 11 (GDF‐11). Methods Nine‐week‐old male SAMP10 mice were randomly assigned non‐YBMT group ( n = 6) 7) that received...
Abstract Cathepsin S (CTSS) is a widely expressed cysteinyl protease that has garnered attention because of its enzymatic and non‐enzymatic functions under inflammatory metabolic pathological conditions. Here, we examined whether CTSS participates in stress‐related skeletal muscle mass loss dysfunction, focusing on protein imbalance. Eight‐week‐old male wildtype (CTSS +/+ ) CTSS‐knockout −/− mice were randomly assigned to non‐stress variable‐stress groups for 2 weeks, then processed...
Background: Chronic psychological stress (CPS) is linked to cardiovascular disease initiation and progression. Given that cysteinyl cathepsin K (CatK) participates in vascular remodeling atherosclerotic plaque growth several animal models, we investigated the role of CatK development experimental neointimal hyperplasia response chronic stress. Methods results: At first, male wild-type (CatK +/+ ) mice underwent carotid ligation injury were subjected immobilization On postoperative stressed...
Exposure to chronic psychosocial stress is a risk factor for atherosclerotic cardiovascular diseases. Given that the 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitor statins prevent atherogenesis, we evaluated whether pitavastatin prevents stress- and high fat diet-induced vascular senescence atherogenesis in apolipoprotein E-deficient (ApoE-/-) mice, with special focus on glucagon-like peptide-1 (GLP-1)/adiponectin (APN) axis.6-week-old ApoE-/- mice loaded high-fat diet were randomly...
We recently demonstrated that proliferin-1 (PLF-1) functions as an apoptotic cell-derived growth factor and plays important role in vascular pathobiology. therefore investigated its muscle regeneration response to cardiotoxin injury. To determine the effects of PLF-1 on regeneration, we used a CTX-induced skeletal injury model 9-week-old male mice were administered with recombinant (rPLF-1) or neutralizing antibody. The injured muscles exhibited increased levels gene expression...
Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular aging, angiogenesis, and atherosclerosis-based disease (ACVD). Dipeptidyl peptidase-4 (DPP-4) complex enzyme (also called CD26) that acts as membrane-anchored cell surface exopeptidase. DPP4 upregulated in metabolic inflammatory disorders. The widespread expression of macrophages immune cells the noncatalytic function signaling binding protein across wide range species suggest teleological role...
Background: Dipeptidyl peptidase-4 (DPP4) inhibition exhibits multiple pleotrophic effects. Hematopoietic stem cell (HSC) activation has been implicated in the pathogenesis of stress-related metabolic disorder and cardiovascular disease. Given that interaction between β3-adrenergic receptor (Adrβ3) signaling immune system may link stress initiation progression disorders, we investigated whether DPP4 regulates over-reactions a chronic mouse model, focusing on HSC activation. Methods Results:...