A5050627722- Muscle Physiology and Disorders
- Virus-based gene therapy research
- Diagnosis and treatment of tuberculosis
- Gallbladder and Bile Duct Disorders
- Appendicitis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Urological Disorders and Treatments
- Genomics and Phylogenetic Studies
- Tissue Engineering and Regenerative Medicine
- Lysosomal Storage Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Myopathies and Dermatomyositis
- Hernia repair and management
- Bacterial Identification and Susceptibility Testing
- Parasites and Host Interactions
- Infections and bacterial resistance
- Research on Leishmaniasis Studies
- Infectious Diseases and Tuberculosis
- Genital Health and Disease
- Colorectal Cancer Screening and Detection
- Testicular diseases and treatments
- Tuberculosis Research and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Tracheal and airway disorders
- Enterobacteriaceae and Cronobacter Research
Inventprise (United States)
2025
Ziguinchor University
2021
Hôpital Principal de Dakar
2007-2020
Hôpital Aristide Le Dantec
2008-2018
University of Washington
2005-2016
Centre Hospitalier National Universitaire de Fann
2008-2016
Seattle University
2016
Muscular Dystrophy Association
2009
Chronic kidney disease is a major complication of Fabry disease. Podocytes accumulate globotriaosylceramide inclusions more than other cell types in patients. Podocyte injury occurs early age, and progressive. Since injured podocytes detach into the urine (podocyturia), we hypothesized that podocyturia would increase patients correlate with clinical severity nephropathy. Urine specimens from 39 24 healthy subjects were evaluated for podocyturia. Most many had The number per gram creatinine...
To explore whether stable transduction of myogenic stem cells using lentiviral vectors could be benefit for treating dystrophic muscles, we generated expressing a functional microdystrophin/enhanced green fluorescence protein fusion (microDys/eGFP) gene. Lentiviral vector injection into neonatal mdx(4cv) muscles resulted in widespread and expression dystrophin at least 2 years. This significant amelioration muscle pathophysiology as assessed by variety histological assays. assess this...
Duchenne muscular dystrophy (DMD) is characterized in skeletal muscle by cycles of myofiber necrosis and regeneration leading to loss fibers replacement with fibrotic connective adipose tissue. The ongoing activation recruitment satellite cells for results regenerative capacity part due proliferative senescence. We explored a method whereby new myoblasts could be generated dystrophic muscles transplantation primary fibroblasts engineered express micro-dystrophin/enhanced green fluorescent...
A promising approach for treating Duchenne muscular dystrophy (DMD) is by autologous cell transplantation of myogenic stem cells transduced with a therapeutic expression cassette. Development this method has been hampered low frequency cellular engraftment, the difficulty tracing transplanted cells, rapid loss carrying marker genes that are unable to halt muscle necrosis and stable transfer large dystrophin gene into cells. We engineered 5.7 kb miniDys – GFP fusion replacing C-terminal...
Strain FF8T (= CSUR P860 = DSM 28259) was isolated in Dakar, Senegal, from the urine of a 65-year-old man with acute cystitis. This strain shows similarity sequence 16S rRNA 98.38% Weeksella virosa, and its GenBank accession numbers are HG931340 CCMH00000000. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis had poor score, ranging 1.32 to 1.56, that did not allow identification bacterium. Using polyphasic study made phenotypic genomic analyses,...
Strain FF9T was isolated in Dakar (Senegal) from a blood-culture taken 16-month-old child. MALDI-TOF analysis did not allow for identification. After sequencing, strain exhibited 98.18% similarity with the 16SrRNA sequence of Paenibacillus uliginis. A polyphasic study phenotypic and genomic analyses showed that is Gram variable, catalase-positive, presents genome 4,569,428 bp (one chromosome but no plasmid) 4,427genes (4,352 protein-coding 75 RNA genes (including 3 rRNA operons). The G+C...
Summary Merozoite surface proteins (MSPs) are critical for parasite invasion; they represent attractive targets antibody-based protection against clinical malaria. To identify protection-associated target MSPs, the present study analysed antibody responses to whole merozoite extract (ME) and defined MSP recombinant antigens in hospitalized patients from a low endemic urban area as function of disease severity (mild versus cerebral malaria). Sera 110 with confirmed severe malaria (CM) 91 mild...
The aim of the study was to describe characteristic features (epidemiological, clinical, paraclinical, therapeutic and evolutive) Plummer-Vinson syndrome. A retrospective descriptive conducted from May 1997 2010 including every patient hospitalized in medical departments “hôpital Principal de Dakar” for dysphagia, iron deficiency anemia upper esophageal web or stricture. Fifty patients were included. mean age 35.6 years sex-ratio 0.14. Laboratory tests showed an all with values haemoglobin...
Strain FF6(T) was isolated from the cervical abscess of a 4-year-old Senegalese boy, in Dakar, Senegal. MALDI-TOF MS did not provide any identification. This strain exhibited 95.17% 16S rRNA sequence identity with Necropsobacter rosorum. Using polyphasic study including phenotypic and genomic analyses, an aero-anaerobic Gram-negative cocobacillus, oxidase positive, genome 2,493,927 bp (1 chromosome but no plasmid) G+C content 46.2% that coded 2,309 protein-coding 53 RNA genes. On basis these...
Il s'agit de décrire les aspects épidémiologiques, cliniques, paracliniques, thérapeutiques et évolutifs la tuberculose péritonéale au Sénégal. d'une étude rétrospective ayant inclus tous cas recensés à l'hôpital Principal Dakar, entre le 1er janvier 1996 30 juin 2006, soit pendant dix ans six mois. Soixante un ont été inclus. L'âge moyen des patients était 36 ans, sexratio 0,9. L'ascite fébrile principale circonstance découverte. Le liquide d'ascite exsudatif dans 92,4 %, lymphocytaire 90,5...
We report the detection and molecular characterization of extended spectrum β-lactamases in a series 112 clinical isolates Enterobacteriaceae from Hôpital Principal de Dakar, Senegal, including five CTX-M-15-producing Morganella morganii isolates, which are reported for first time this country.
Rapporter notre expérience de prise en charge des lésions intestinales lors contusions l’abdomen milieu défavorisé. Ce travail rétrospectif portait sur neuf dossiers patients, opérés au service urgences chirurgicales l’Hôpital Régional Thiès entre janvier 2009 et juillet 2011 pour une lésion intestinale secondaire à contusion abdominale. Nous avions analysé les circonstances étiologiques, données cliniques, paracliniques, le traitement suites opératoires. Il s’agissait 8 hommes d’une femme....
La fréquence de la drépanocytose au Sénégal et l'amélioration des moyens diagnostiques permettent actuellement confier chirurgien un nombre croissant d'enfants d'adolescents porteurs lithiases vésiculaires dans ce contexte hématologique particulier. Le but auteurs est faire état leur expérience cholécystectomie laparoscopique chez l'enfant l'adolescent. Il s'agissait 43 patients d'un âge moyen 13 ans qui ont bénéficié d'une par abord utilisant quatre trocarts en position dite « américaine »....