Manuel Blessing

ORCID: 0000-0001-5861-1558
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About
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Research Areas
  • Advanced Radiotherapy Techniques
  • Medical Imaging Techniques and Applications
  • Radiation Therapy and Dosimetry
  • Advanced X-ray and CT Imaging
  • Radiation Dose and Imaging
  • Digital Radiography and Breast Imaging
  • Cancer survivorship and care
  • Radiation Detection and Scintillator Technologies
  • Advanced MRI Techniques and Applications
  • Breast Lesions and Carcinomas
  • Cancer and Skin Lesions
  • Airway Management and Intubation Techniques
  • Lung Cancer Diagnosis and Treatment
  • Multi-Criteria Decision Making
  • Clinical practice guidelines implementation
  • Nuclear Physics and Applications
  • Photoacoustic and Ultrasonic Imaging
  • Breast Cancer Treatment Studies
  • Animal Behavior and Welfare Studies
  • Photocathodes and Microchannel Plates
  • AI-based Problem Solving and Planning
  • Radiomics and Machine Learning in Medical Imaging
  • Cancer Diagnosis and Treatment
  • Effects of Environmental Stressors on Livestock
  • solar cell performance optimization

University Hospital Heidelberg
2010-2021

Heidelberg University
2010-2021

University Medical Centre Mannheim
2009-2019

Medizinische Fakultät Mannheim
2012-2018

UCLA Medical Center
2013

Brigham and Women's Hospital
2009-2011

Harvard University
2011

Icahn School of Medicine at Mount Sinai
2010

Dana-Farber Cancer Institute
2009

Dana-Farber Brigham Cancer Center
2009

Long image acquisition times of 60–120 s for cone-beam CT (CBCT) limit the number patients with lung cancer who can undergo volume guidance under breathhold. We developed a low-dose dual-energy kilovoltage–megavoltage-cone-beam (kVMV-CBCT) based on clinical treatment unit reducing imaging time to ⩽15 s. Simultaneous kVMV-imaging was achieved by dedicated synchronization hardware controlling output linear accelerator (linac) detector panel readout signals, preventing artifacts from...

10.1088/0031-9155/55/15/001 article EN Physics in Medicine and Biology 2010-07-08

10.1016/j.jbi.2019.103127 article EN publisher-specific-oa Journal of Biomedical Informatics 2019-02-13

Purpose Combined ultrafast 90°+90° kV-MV-CBCT within single breath-hold of 15s has high clinical potential for accelerating imaging lung cancer patients treated with deep inspiration (DIBH). For feasibility kV-MV-CBCT, dose exposure to be small compared prescribed dose. In this study, kV-MV output is evaluated and clinically-established kV-CBCT. Methods Accurate calibration was performed kV MV energy; beam quality determined. direct comparison output, relative biological effectiveness (RBE)...

10.1371/journal.pone.0187710 article EN cc-by PLoS ONE 2017-11-10

A phenomenological kV beam model was developed to address attenuation and scatter in radiographic images for the purpose of cone-beam imaging. Characterization a terms minimal number parameters calculation radiographs scanned objects are main applications this model. Model derived from homogeneous solid water phantoms various depths field sizes. The response detector beams is factorized into different contributions such as output factor, tissue-air ratio off-axis ratio, with each...

10.1088/0031-9155/55/19/011 article EN Physics in Medicine and Biology 2010-09-16

Es wird der Fall einer 47jährigen Patientin vorgestellt, bei sowohl ein Cystosarcoma phylloides malignum als auch duktales Karzinom in derselben Brust vorlag. Die Therapie, Prognose und Nachsorge dieses selten auftretenden Kombinations-Tumors mit Fällen aus Literatur diskutiert. Als Therapie sollte eine Ablatio mammae, modifiziert nach Patey, axillarer Lymphonodektomie durchgeführt werden. Eine weitere adjuvante muß sich an den Ergebnissen des Tumor-Stagings orientieren. Wichtig ist...

10.1055/s-2007-1023181 article DE Geburtshilfe und Frauenheilkunde 1992-09-01

Purpose/Objective: To develop a novel method for 4DCT data acquisition that avoids the pitfalls of existing methods, including abutment discontinuities, management irregular breathing, and high dose.Materials Methods: The proposed uses simultaneous breathing surrogate measurement (pneumatic bellows around abdomen) standard fast helical scanning to acquire breathingcorrelated CT scans.The scanner is operated in mode using pitch 1, fastest rotation rate (<0.3s), low mAs (40mAs) covering...

10.1016/s0167-8140(15)32366-5 article EN cc-by-nc-nd Radiotherapy and Oncology 2013-03-01

Purpose: This project presents an analysis of the point spread function (PSF) isocentric digital tomosynthesis (DTS). DTS is a limited angle 3‐ dimensional reconstruction from cone beam projections, with high resolution for excellent imaging both bony anatomy and soft tissue. Its major application on‐board imaging. The scans can be acquired during single breath hold, thus eliminating respiratory motion artifacts without gating techniques. Method Materials: geometry linear accelerator (Clinac...

10.1118/1.2241847 article EN Medical Physics 2006-06-01
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