A5114063629- Pregnancy and Medication Impact
- Vestibular and auditory disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Ocular Diseases and Behçet’s Syndrome
- Peripheral Neuropathies and Disorders
- Inflammation biomarkers and pathways
- Tuberculosis Research and Epidemiology
- Down syndrome and intellectual disability research
- Pericarditis and Cardiac Tamponade
- Reproductive System and Pregnancy
- Mast cells and histamine
- Systemic Lupus Erythematosus Research
- Glaucoma and retinal disorders
Western University of Health Sciences
2023-2025
Chonnam National University Hospital
2019
Extrapulmonary tuberculosis (EPTB) accounts for approximately 17% of all Mycobacterium (M.tb) infections globally. Immunocompromised individuals, such as those with HIV infection or type 2 diabetes mellitus (T2DM), are at an increased risk EPTB. Previous studies have demonstrated that patients and T2DM exhibit diminished synthesis glutathione (GSH) synthesizing enzymes. In a murine model, we showed the diethyl maleate (DEM)-induced depletion GSH in lungs led to M.tb burden impaired pulmonary...
This study evaluated tumour necrosis factor-α, interleukins 10 and 12, interferon-γ levels, peripheral blood mononuclear cells, clusters of differentiation 17c 86 expression in unilateral sudden sensorineural hearing loss.Twenty-four patients with loss, 24 individuals normal no history loss (who were attending the clinic for other problems), enrolled. Peripheral 11c isolated analysed. Plasma supernatant levels interferon-γ, 12 measured.There significant differences respect to age gender....
Glutathione (GSH) is an important intracellular antioxidant responsible for neutralizing reactive oxygen species (ROS). Our laboratory previously demonstrated that the oral administration of liposomal GSH improves immune function against mycobacterium infections in healthy patients along with HIV and Type 2 diabetes. We aim to determine if topical application a glutathione-cyclodextrin nanoparticle complex (GSH-CD) confers therapeutic effect infections. In our study, participants received...
Abstract Background DYRK1A belongs to dual-specificity tyrosine (Y) phosphorylation regulated kinase (DYRK) family which is known be activated through autophosphorylation of residues in the activation loop and phosphorylates their substrates on serine threonine residues. Other members this include DYRK1B, DYRK2, DYRK3, DYRK4. Studies have revealed that DYRK plays an important role regulating cell proliferation apoptosis. has been reported strongly expressed brain regulate various functions....