A5085147685- Catalytic C–H Functionalization Methods
- Virus-based gene therapy research
- Oxidative Organic Chemistry Reactions
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Endometriosis Research and Treatment
- Asymmetric Hydrogenation and Catalysis
- Nanomaterials for catalytic reactions
- Synthetic Organic Chemistry Methods
- Ovarian function and disorders
- Down syndrome and intellectual disability research
- Renal and related cancers
- Uterine Myomas and Treatments
- CAR-T cell therapy research
- Advanced MRI Techniques and Applications
- CRISPR and Genetic Engineering
- Catalysis for Biomass Conversion
- Inflammation biomarkers and pathways
- Cutaneous Melanoma Detection and Management
- Retinal Development and Disorders
- Reproductive System and Pregnancy
- Medical Imaging Techniques and Applications
- Synthesis and Biological Evaluation
- Cardiac Imaging and Diagnostics
Korea Research Institute of Bioscience and Biotechnology
2024
University of Pittsburgh Medical Center
2023
Seoul National University
2000-2021
Herein, we describe novel iron-catalyzed transfer hydrogenation between alcohols and 1-(2-nitrophenyl)pyrroles for the synthesis of pyrrolo[1,2-α]quinoxalines. The tricarbonyl (η4-cyclopentadienone) iron complex catalyzed oxidation reduction nitroarenes, corresponding aldehydes aniline were generated in situ. resulting Pictet–Spengler-type annulation/oxidation completed quinoxaline structure formation. protocol tolerated various kinds functional groups provided 29 samples 4-substituted...
Herein, we describe the direct synthesis of pyrrolo[1,2-α]quinoxaline via oxidative coupling between methyl arene and 1-(2-aminophenyl) pyrroles. Oxidation benzylic carbon was achieved by di-t-butyl peroxide in presence an iron catalyst, followed conversion to activated aldehyde situ. Oxygen played a crucial role oxidation process accelerate benzaldehyde formation. Subsequent Pictet–Spengler-type annulation completed quinoxaline structure. The protocol tolerated various kinds functional...
With recent advances in adeno-associated virus (AAV)-based gene therapy, efficacy and toxicity screening have become essential for developing therapeutic drugs retinal diseases. Retinal organoids from human pluripotent stem cells (hPSCs) offer a more accessible reproducible test platform evaluating AAV-based therapy. In this study, hPSCs were differentiated into composed of various types cells. The transduction efficiencies AAV2 AAV8, which are widely used clinical trials inherited diseases,...
Endometriosis is a major cause of infertility and pelvic pain, affecting more than 10% reproductive-aged women. Progesterone resistance has been observed in the endometrium women with this disease, as evidenced by alterations progesterone-responsive gene protein expression. cAMPResponse Element-Binding 3-like 1 (Creb3l1) previously identified progesterone receptor (PR) target mouse uterus via high density DNA microarray analysis. However, CREB3L1 function not studied context endometriosis...
Herein, we describe the iron(III)-catalyzed oxidative coupling of alcohol/methyl arene with 2-amino phenyl ketone to synthesize 4-quinolone. Alcohols and methyl arenes are oxidized aldehyde in presence an iron catalyst di-tert-butyl peroxide, followed by a tandem process, condensation amine/Mannich-type cyclization/oxidation, complete 4-quinolone ring. This method tolerates various kinds functional groups provides direct approach synthesis 4-quinolones from less functionalized substrates.
Purpose We investigated the reproducibility of quantification left ventricular volumes and ejection fraction, grading myocardial wall motion systolic thickening with gated single-photon emission computed tomography (SPECT) Cedars software. Patients, materials methods performed post-stress SPECT in 33 consecutive patients twice sequentially situ. Sixteen frames per cycle were used for gating. Using quantitative software fraction (EF) calculated. Wall was graded using 5- 4-point scores,...
This study was conducted to improve the yield of mature oocytes from in vitro-culture ovarian primary follicles by optimizing follicle retrieval neonatal mice different ages. Primary 75 99 μm diameter were collected daily 7- 14-day-old mice, and subsequently cultured α-MEM medium. Number isolated, growth during maturation intrafollicular monitored. Overall, mean number preantral per animal improved 10.7 88.7 as age donors increased 7 14-day-old. gradually up 11-day-old (35.7 an animal), then...
Abstract Background DYRK1A belongs to dual-specificity tyrosine (Y) phosphorylation regulated kinase (DYRK) family which is known be activated through autophosphorylation of residues in the activation loop and phosphorylates their substrates on serine threonine residues. Other members this include DYRK1B, DYRK2, DYRK3, DYRK4. Studies have revealed that DYRK plays an important role regulating cell proliferation apoptosis. has been reported strongly expressed brain regulate various functions....