A5049894121- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Intensive Care Unit Cognitive Disorders
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Neurotoxicity Research
- Cardiac Valve Diseases and Treatments
- Anesthesia and Sedative Agents
- Cardiac Health and Mental Health
- Delphi Technique in Research
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Enhanced Recovery After Surgery
- Hemodynamic Monitoring and Therapy
- Pericarditis and Cardiac Tamponade
- Infective Endocarditis Diagnosis and Management
- Blood transfusion and management
- Healthcare professionals’ stress and burnout
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Ischemia and Reperfusion
- Airway Management and Intubation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Sepsis Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
Western Sydney University
2022-2025
Westmead Hospital
2019-2025
Translational Research Institute
2024
Maastricht University
2024
University Medical Center Utrecht
2010-2020
Auckland City Hospital
2019
Monash University
2017-2019
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2018
Utrecht University
2011-2018
Queen Mary University of London
2018
Prophylactic corticosteroids are often administered during cardiac surgery to attenuate the inflammatory response cardiopulmonary bypass and surgical trauma; however, evidence that routine corticosteroid use can prevent major adverse events is lacking.To quantify effect of intraoperative high-dose dexamethasone on incidence in patients undergoing surgery.A multicenter, randomized, double-blind, placebo-controlled trial 4494 aged 18 years or older with at 8 centers The Netherlands enrolled...
Abstract Background: Cardiac surgery can be complicated by postoperative cognitive decline (POCD), which is characterized impaired memory function and intellectual ability. The systemic inflammatory response that induced major cardiopulmonary bypass may play an important role in the etiology of POCD. Prophylactic corticosteroids to attenuate therefore reduce risk authors investigated effect intraoperative high-dose dexamethasone on incidence POCD at 1 month 12 months after cardiac surgery....
Administration of prophylactic glucocorticoids has been suggested as a strategy to reduce postoperative AKI and other adverse events after cardiac surgery requiring cardiopulmonary bypass. In this post hoc analysis large placebo-controlled randomized trial dexamethasone in 4465 adult patients undergoing surgery, we examined severe AKI, defined use RRT, primary outcome. Secondary outcomes were doubling serum creatinine level or AKI-RRT, well AKI-RRT in-hospital mortality (RRT/death). The...
High-dose corticosteroids have been used to attenuate the inflammatory response cardiac surgery and cardiopulmonary bypass, but patient outcome benefits remain unclear. The primary aim was determine whether using dexamethasone superior not increase number of home days in first 30 after surgery. secondary evaluate efficiency, value, impact novel trial design.
Age-related cognitive impairment is rising in prevalence but not yet fully characterized terms of its epidemiology. Here, we aimed to elucidate the role obesity, diabetes and hypertension as candidate risk factors.Original baseline data from 3 studies (OCTOPUS, DECS, SuDoCo) were obtained for secondary analysis cross-sectional associations diabetes, hypertension, blood pressure, obesity (body mass index [BMI] ≥30 kg/m2) BMI with presence log-binomial regression analyses. Cognitive was...
A proportion of patients due to anatomical variation do not receive chest compressions over the left ventricle. Transoesophageal echocardiography (TOE) has potential impact survival rates by identifying area maximal compression (AMC), potentially improving forward flow and systemic perfusion in cardiac arrest. There is a paucity data regarding use TOE during out hospital arrest (OHCA) pre-hospital setting, with most coming from studies performed hospital. We therefore set retrospectively...
Abstract Introduction Blood lactate levels are increasingly used to monitor patients. Steroids frequently administered critically ill However, the effect of steroids on has not been adequately investigated. We studied a single intraoperative high dose dexamethasone and glucose in patients undergoing cardiac surgery. Methods The Dexamethasone for Cardiac Surgery (DECS) trial was multicenter randomized 1 mg/kg versus placebo clinical outcomes after surgery adults. Here we report pre-planned...
Objective: Cardiac surgery and postoperative admission to the ICU may lead posttraumatic stress disorder depression. Perioperatively administered corticosteroids potentially alter risk of development these psychiatric conditions, by affecting hypothalamic-pituitary-adrenal axis. However, findings previous studies are inconsistent. We aimed assess effect a single dose dexamethasone compared with placebo on symptoms depression health-related quality life after cardiac admission. Design:...
Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known factors predisposing patients to POCD. Our objective was estimate the POCD associated with exposure preoperative diabetes, hypertension, and obesity.Original data from 3 randomised controlled trials (OCTOPUS, DECS, SuDoCo) were obtained for secondary analysis on baseline blood pressure, obesity (BMI ≥30 kg/m2), BMI as in multiple logistic regression models. Risk estimates...