A5011388488- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Posttraumatic Stress Disorder Research
- Neuroendocrine regulation and behavior
- Resilience and Mental Health
- Intensive Care Unit Cognitive Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cardiac Health and Mental Health
- Identity, Memory, and Therapy
- Patient-Provider Communication in Healthcare
- Healthcare professionals’ stress and burnout
- Child and Adolescent Psychosocial and Emotional Development
- Migration, Health and Trauma
- Advanced Data Processing Techniques
- Attachment and Relationship Dynamics
- Meta-analysis and systematic reviews
- Gene expression and cancer classification
- Emotional Intelligence and Performance
- Birth, Development, and Health
- Family and Patient Care in Intensive Care Units
- Genetics, Bioinformatics, and Biomedical Research
- Child Abuse and Trauma
- Cognitive Science and Education Research
- Communication in Education and Healthcare
Vrije Universiteit Amsterdam
2023-2024
Amsterdam University Medical Centers
2022-2024
Utrecht University
2015-2024
University Medical Center Utrecht
2016-2024
Ministry of Defence
2019-2024
GGZ inGeest
2023-2024
Amsterdam Neuroscience
2024
Public Health Service of Amsterdam
2024
Czech Academy of Sciences, Institute of Psychology
2016
Leiden University
2016
The diagnosis of incurable cancer may evoke physiological arousal in patients. Physiological can negatively impact patients' recall information provided the medical consultation. We aim to investigate whether clinicians' affective communication during a bad news consultation will decrease and improve recall.Healthy women (N=50), acting as analogue patients, were randomly assigned watch one out two versions scripted video-vignette which clinician's differed: standard vs. communication....
Patients' recall of provided information during bad news consultations is poor. According to the attentional narrowing hypothesis, emotional arousal caused by might be responsible for this hampered processing. Because affective communication has proven effective in tempering patients' reactions, current study used an experimental design explore whether physician's decreases anxiety and uncertainty improves recall.Two scripted video-vignettes a consultation were which verbal was manipulated...
Stress, encompassing psychological, physical, and physiological challenges, is an important factor affecting individual's well-being potentially leading to psychiatric, neurodegenerative, immune, metabolic disorders. However, not everyone exposed stress develops these conditions, highlighting the concept of resilience. Resilience a dynamic process categorized into four dimensions: pre-existing resilience capacity, ongoing processes, post-stress outcomes, recovery from psychopathologies....
Objective: Cardiac surgery and postoperative admission to the ICU may lead posttraumatic stress disorder depression. Perioperatively administered corticosteroids potentially alter risk of development these psychiatric conditions, by affecting hypothalamic-pituitary-adrenal axis. However, findings previous studies are inconsistent. We aimed assess effect a single dose dexamethasone compared with placebo on symptoms depression health-related quality life after cardiac admission. Design:...
Both Childhood Adversity (CA) and resilience are heterogeneous constructs that differently conceptualized operationalized across studies. CA in any operationalization is associated with mental physical health problems the lifespan, but some individuals fare quite well after exposure. The large body of studies investigating its consequences includes a growing number on following However, heterogeneity study design conceptualization hampers integration findings our understanding positive...
Memories about stressful experiences need to be both specific and generalizable adequately guide future behavior. Memory strength is influenced by emotional significance, contextualization (i.e., encoding with their contextual details) enables selective context-dependent retrieval protects against overgeneralization. The current randomized-controlled study investigated how the early late phase of endogenous stress response affects neutral negative information. One hundred healthy male...
Information processing under stressful circumstances depends on many experimental conditions, like the information valence or point in time at which brain function is probed. This also holds true for memorizing contextual details (or 'memory contextualization'). Moreover, large interindividual differences appear to exist (context-dependent) memory formation after stress, but it mostly unknown individual characteristics are essential. Various were explored from a theory-driven and data-driven...
Abstract Background Major depressive disorder (MDD) is a heterogeneous psychiatric disorder. Childhood trauma (CT, emotional/physical/sexual abuse or neglect before the age of 18) one largest and most consistent risk factors for development poor course MDD. Overactivity HPA-axis stress hormone cortisol thought to play role in vulnerability MDD following exposure CT. Rodent experiments showed that antagonism glucocorticoid receptor (GR) at adult reversed effects early life stress. Similarly,...
The formation of context-dependent fear memories (fear contextualization) can aid the recognition danger in new, similar, situations. Overgeneralization is often seen as hallmark anxiety and trauma-related disorders. In this randomized-controlled study, we investigated whether exposure to a psychosocial stressor influences retention contextualization generalization time-dependent manner. Trier Social Stress Test was used induce stress. Healthy male participants (n = 117) were randomly...
While many people experience potentially threatening events during their life, only a minority develops posttraumatic stress disorder (PTSD). The identification of individuals at risk among those exposed to trauma is crucial for PTSD prevention in the future. Since re-experiencing elements outside original trauma-context core feature PTSD, we investigate if ability bind memories encoding context (i.e. memory contextualisation) predicts vulnerability. We hypothesize that pre-trauma neutral...
Growing interest in interindividual differences stress neuroendocrinology has created a need to combine data from multiple laboratory acute induction studies allow large-scale individual participant (IPD) meta-analyses. However, established cortisol response indicators such as area under the curve (AUC) are inherently affected by sampling timing and duration, although what extent remains unknown. Here, we leveraged large, combined dataset (STRESS-EU; n=1,295) develop novel model-based that...
Abstract Background Current evidence-based treatments for post-traumatic stress disorder (PTSD) are efficacious in only part of PTSD patients. Therefore, novel neurobiologically-informed approaches urgently needed. Clinical and translational neuroscience point to altered learning memory processes as key (models of) psychopathology. We extended this notion by clarifying at a meta-level i) the role information valence, i.e. neutral versus emotional/fearful, ii) comparability between clinical...
IntroductionTo assess cerebral hemodynamics in an experimental sepsis model.Methods Nineteen juvenile female Hungahib pigs were subjected into control group (n = 9) or septic 10).Under general anesthesia animals of the group, Escherichia coli culture (2.5 × 10 5 /ml; strain: ATCC 25922) was intravenously administrated a continuously increasing manner as follows: 2 ml fi rst 30 minutes, then 4 minutes and afterwards 16 ml/hour for hours (so total 9.5 6 E. within 3 hours).In maintained 8...
(Abstracted from Crit Care Med, 44:512–520, 2016) Cardiac patients admitted postoperatively to the intensive care unit may experience posttraumatic stress disorder and depression. Studies have shown an association between administering corticosteroids perioperatively a reduction in development of these conditions.