A5030699341- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Vascular Malformations Diagnosis and Treatment
- Flavonoids in Medical Research
- Esophageal and GI Pathology
- Acute Ischemic Stroke Management
- Folate and B Vitamins Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Medicinal Plant Pharmacodynamics Research
- Galectins and Cancer Biology
- Antimicrobial agents and applications
- Signaling Pathways in Disease
- Cardiovascular Health and Risk Factors
- Moyamoya disease diagnosis and treatment
- Microbial Metabolism and Applications
- Cardiovascular Health and Disease Prevention
- Dementia and Cognitive Impairment Research
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Peptidase Inhibition and Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
Zhujiang Hospital
2022-2025
Southern Medical University
2022-2025
Reactive Oxygen Species (ROS) are widely accepted as a pernicious factor in the progression of intracranial aneurysm (IA), which is eminently related to cell apoptosis and extracellular matrix degradation, but mechanism remains be elucidated. Recent evidence has identified that enhancement Cyclophilin D (CypD) under stress conditions plays critical role ROS output, thus accelerating vascular destruction. However, no study confirmed whether cypD detrimental mediator degradation setting IA...
Background Flow diverter devices (FDs) are increasingly used for treating unruptured intracranial aneurysms (UIAs), but limited studies compared different FDs. Objective To conduct a propensity score matched analysis comparing the Pipeline embolization device (PED) and Tubridge (TED) UIAs. Methods Patients with UIAs treated either PED or TED between July 2016 2022 were included. Propensity matching was performed to adjust age, sex, comorbidities, smoking, drinking, aneurysm size, morphology,...
Background Aneurysm wall enhancement (AWE) on vessel imaging (VWI) scans is a robust biomarker for aneurysmal vulnerability. This study aimed to explore the association of different sleep patterns with AWE and other vulnerability features. Methods Patients unruptured intracranial aneurysms were prospectively recruited. Sleep characteristics collected through standard questionnaire. Poor quality was defined using Pittsburgh Quality Index (PSQI)>5. Cross-sectional multistate predictive...
Introduction The indicator of flow diverters (FDs) received approval extension for small (<7 mm) unruptured intracranial aneurysms (UIAs). However, the factors related to aneurysm occlusion remain unclear. Thus, we conducted a multicenter analysis explore risk incomplete (ICO) following FD implantation UIAs. Methods We retrospectively reviewed patients from 5 comprehensive hospitals in China with UIAs treated either Pipeline or Tubridge between September 2018 and 2022. Baseline data were...
Background: Traditional Chinese medicine (TCM) has been widely used in the treatment of human diseases. However, synergistic effects multiple TCM prescriptions stroke have not thoroughly studied. Objective study: This study aimed to reveal mechanisms underlying these and identify active compounds. Methods: Herbs compounds Di-Tan Decoction (DTD), Xue-Fu Zhu-Yu (XFZYD), Xiao-Xu-Ming (XXMD) were acquired from TCMSP database. SEA, HitPick, TargetNet web servers for target prediction. The...
Abstract Background Taohong Siwu Decoction (THSWD) is a widely used traditional Chinese medicine (TCM) prescription in the treatment of ischemic stroke. There are thousands chemical components THSWD. However, key functional still poorly understood. This study aimed to construct mathematical model for screening active ingredients TCM prescriptions and apply it THSWD on Methods Botanical drugs compounds were acquired from multiple public databases. All initially screened by ADMET properties....
Background and purpose Recent observational studies have reported that serum total homocysteine (tHcy) is associated with intracranial aneurysms (IAs). However, the causal effect of tHcy on IAs unknown. We leveraged large-scale genetic association real-world data to investigate IA formation. Methods performed a two-sample Mendelian randomisation (MR) using publicly available genome-wide summary statistics relationship between IAs, following recommendations Strengthening Reporting...
<title>Abstract</title> Flow-diverter devices (FDs) are effective in treating intracranial aneurysms (IAs) but carry substantial periprocedural risks, particularly ischemic complications. This study aimed to determine if elevated Systemic Immune-Inflammation Index (SII) can independently predict these risks and assess the impact of age dual antiplatelet therapy on this association. We conducted a retrospective analysis patients treated with FDs between February 2016 August 2023, using blood...