A5044631376- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Hydrogels: synthesis, properties, applications
- Cancer-related Molecular Pathways
- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- RNA Research and Splicing
- Pressure Ulcer Prevention and Management
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Tea Polyphenols and Effects
- RNA modifications and cancer
- Bone Tumor Diagnosis and Treatments
- Supramolecular Self-Assembly in Materials
- Orthopedic Surgery and Rehabilitation
- Advanced Drug Delivery Systems
- Bone fractures and treatments
- Tannin, Tannase and Anticancer Activities
- Extracellular vesicles in disease
- Osteoarthritis Treatment and Mechanisms
- Elbow and Forearm Trauma Treatment
- Sirtuins and Resveratrol in Medicine
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
University of South China
2021-2024
Changsha Central Hospital
2015-2024
Guangxi Research Institute of Chemical Industry
2023
Second Xiangya Hospital of Central South University
2014-2015
Central South University
2013-2015
miR-126 plays an important role in the proliferation, invasion, migration, and chemotherapeutics resistance cancer. Epigallocatechin-3-gallate (EGCG), as major polyphenolic constituent present green tea, is a promising anticancer agent. However, of EGCG remains unclear. Here, we investigated effects on cell viability, apoptosis, cycle distribution osteosarcoma cells sensitization to EGCG.The apoptosis were analyzed using MTT assay flow cytometry.Our results showed that (0.025, 0.05, 0.1, 0.2...
Diabetic ulcer is usually seen in people with uncontrolled blood sugar. Reportedly, many factors such as impaired glucose metabolism, and macrovascular microvascular diseases caused angiogenesis disorders delayed the healing of diabetic ulcers, thus affecting body's nutrition, immune function. This study aimed to explore effect paeonol on skin wound rats related mechanism. A rat model was established. High glucose-treated mouse fibroblasts were co-cultured M1 or M2-polarized macrophages...
Osteosarcoma (OS) has become one of the most common primary malignant tumors in children and adolescents with a poor prognosis mainly due to high metastasis. A disintegrin metalloprotease 9 (ADAM-9) plays role tumorigenesis, invasion, metastasis several tumors. miR-126 been reported be downregulated OS tumor. However, involvement ADAM-9 pathology relationship between cells remain unclear. In this study, using quantitative reverse-transcribed PCR (qRT-PCR) analysis on 37 pairs matched...
We investigated the efficacy of annular ligament reconstruction by suture anchor in treatment radial head dislocation (RHD) children.A total 20 RHD children nderwent surgery using anchor. Preoperative and postoperative elbow functions were evaluated according to Broberg Morrey 100-point scale. Recovery nerve function was assessed Chinese Medical Association Hand Surgery Branch Upper Limb Functional Assessment Standard. All statistical analyses performed SPSS version 17.0 software.All who...
The establishment of novel chemotherapy drugs for osteosarcoma is urgently required, and the mechanisms effects cisplatin (DDP) methotrexate (MTX) in current treatment have not been fully elucidated. present study aimed to observe effect DDP, MTX rapamycin on cell proliferation apoptosis, investigate association between miR‑126 DDP cells. miR‑126‑overexpressing ‑silencing lentiviral vectors were constructed, MG63 U‑2 OS cells infected. An MTT assay was conducted detect transfected...
Background: Delayed wound healing, a common problem in patients with diabetes mellitus (DM), is associated impaired keratinocyte autophagy. Epigallocatechin gallate (EGCG), catechin, has been proven to promote diabetic healing. This study aims explore the therapeutic mechanism of EGCG on Methods: High glucose (HG)-induced keratinocytes and streptozotocin (STZ)-induced DM rats were prepared intervened examine its effects vivo vitro settings. The AMPK inhibitor, Compound C, was utilized...
We have screened candidate marker genes for the diagnosis of osteoarthritis and predicted their regulatory mechanisms. Six expression chips tissue samples one chip peripheral blood mononuclear cell (PMBC) were obtained from GEO database. Differential analysis, GSEA, WGCNA performed on integra-ted sample data with batch correction. Can-didate intersection significantly related to in differentially expressed genes. ROC analysis was PMBC samples. Genes AUC values greater than 0.6 retained as...