A5014619140- Protease and Inhibitor Mechanisms
- Helminth infection and control
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Family and Disability Support Research
- Celiac Disease Research and Management
- Child Nutrition and Feeding Issues
- Animal Nutrition and Physiology
- Animal Genetics and Reproduction
- Coccidia and coccidiosis research
- Parasite Biology and Host Interactions
- Blood Coagulation and Thrombosis Mechanisms
- Pluripotent Stem Cells Research
- Innovative Teaching Methods
- Streptococcal Infections and Treatments
- Microscopic Colitis
- Optimism, Hope, and Well-being
- Resilience and Mental Health
- Galectins and Cancer Biology
- Respiratory and Cough-Related Research
- Obsessive-Compulsive Spectrum Disorders
- Parasitic Diseases Research and Treatment
University of New England
2016-2025
RMIT University
2023
The University of Melbourne
2023
University of the Sunshine Coast
2023
Ecosystem Sciences
2023
Peter Doherty Institute
2023
Sheffield Hallam University
2023
Commonwealth Scientific and Industrial Research Organisation
2008-2018
Animal, Food and Health Sciences
2012-2018
Scripps Research Institute
2003-2009
Non-conventional feed ingredients are receiving more interest in their ability to increase farming efficiency, sustainability and animal performance. The objective of this study was determine the optimal rate inclusion level full-fat black soldier fly larvae (BSFL) broiler diets evaluate impact on performance, nutrient digestibility, immune system (blood cells intraepithelial lymphocytes). A total 400 male day-old Ross 308 broilers were randomly assigned 5 treatment groups with 8 replicates...
Lymphocytic hypophysitis is part of the spectrum organ-specific autoimmune diseases, and although its histopathology well documented, pathogenesis unclear. Serum autoantibodies directed against a 49-kDa cytosolic protein are detected by immunoblotting in 70% patients with biopsy-proven lymphocytic hypophysitis. Here we report purification identification this first target autoantigen The has molecular mass 49 kDa, localization, ubiquitous tissue distribution. was purified from monkey brain...
Sydenham chorea (SC) is the neurological manifestation associated with acute rheumatic fever (ARF). ARF and heart disease (RHD) are autoimmune complications triggered by a group A streptococcal (GAS) infection. In ARF/RHD SC, tissue cross-reactive antibodies T-cells generated against GAS antigens have been implicated in pathogenesis. known to cross-react neuronal proteins causing manifestations including choreiform movements neuropsychiatric symptoms such as irritability, attention deficit,...
This study reports on the molecular systems biology of gastrointestinal nematode (GIN) infection and potential biomarkers for GIN resistance in sheep. Microarray gene expression data were obtained 3 different tissues at 4 time points from sheep artificially challenged with two types nematodes, Haemonchus contortus (HC) Trichostrongylus colubriformis (TC). We employed an integrated approach, integrating main methods: standard differential analyses, weighted co-expression network analyses...
The aim of the present study was to determine direct cause mutation-induced, increased ovulation rate in Booroola Merino (BB) sheep. Granulosa cells were removed from antral follicles before and post-ovulation BB (n=5) WT (n=12) ewes. Direct immunofluorescence measurement mature cell surface receptors using flow cytometry demonstrated a significant up-regulation FSH receptor (FSHR), transforming growth factor beta type 1, bone morphogenetic protein (BMPR1B), LH (LHR) density FSHR LHR provide...
Urokinase-type plasminogen activator (uPA) induces cell adhesion and chemotactic movement. uPA signaling requires its binding to receptor (uPAR/CD87), but how glycosylphosphatidylinositol-anchored uPAR mediates is unclear. a ligand for several integrins (e.g. α5β1) supports cell-cell interaction by on apposing cells (in trans). We studied whether of α5β1 in cis involved migration Chinese hamster ovary response immobilized uPA. This process was temperature-sensitive required mitogen-activated...
Summary It has been questioned whether there are receptors for urokinase-type plasminogen activator (uPA) that facilitate activation other than the high affinity uPA receptor (uPAR/CD87) since studies of uPAR knockout mice did not support a major role in activation. also promotes cell adhesion, chemotaxis, and proliferation besides These uPA-induced signaling events mediated by uPAR,but unidentified,lower-affinity kringle.We found binds specifically to integrin αvβ3 on CHO cells depleted...
To characterize the role of a range oxidant, antioxidant and mucous-related genes in primary response to gastrointestinal nematodes, groups genetically resistant sheep were challenged with either Haemonchus contortus or Trichostrongylus colubriformis necropsied for retrieval tissue at days 0, 3, 7, 14 21. determine if was localized site parasite infection, four different gut tissues sampled: abomasum, proximal distal jejunum ileum. Basal expression patterns all candidate determined using day...
Broilers commonly suffer from necrotic enteritis (NE). Other gastrointestinal infectious diseases affect poultry, including nematode infections which are considered a re-emerging disease in barn and free-range systems. The aim of this study was to characterize the immune response broilers after artificial infection with NE contrast these responses Ascaridia galli determine whether parameters measured during course can be used distinguish infected uninfected birds. A total 96 one-day-old male...
An emerging area of research has documented a novel role for the plasminogen activation system in regulation neurotransmitter release. Prohormones, secreted by cells within sympathoadrenal system, are processed plasmin to bioactive peptides that feed back inhibit secretagogue-stimulated Catecholaminergic prototypic prohormone-secreting cells. Processing prohormones is enhanced presence catecholaminergic cells, and enhancement requires binding plasmin(ogen) cellular receptors. Consequently,...
The transition to tertiary level learning requires students take responsibility for their own and independently synthesise conceptual knowledge specific discipline. We designed an interactive online lesson that aimed build student engagement foster self-regulation of understanding a foundation concept in molecular biology first year general unit delivered both on-campus off-campus cohorts. Students demonstrated high following exposure the lesson, more attempted exam question, subsequently...