A5028082874- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Apelin-related biomedical research
- Gestational Diabetes Research and Management
- Cardiomyopathy and Myosin Studies
- Birth, Development, and Health
- Diabetes Management and Research
- Hormonal Regulation and Hypertension
- Cardiac Valve Diseases and Treatments
- Adolescent and Pediatric Healthcare
- Obesity, Physical Activity, Diet
- Genetic Syndromes and Imprinting
- Parathyroid Disorders and Treatments
- Health and Medical Research Impacts
- Galectins and Cancer Biology
- Diversity and Career in Medicine
- Diabetes and associated disorders
- interferon and immune responses
- Genomics and Rare Diseases
- Neurogenetic and Muscular Disorders Research
- Prenatal Screening and Diagnostics
- Porphyrin Metabolism and Disorders
- CNS Lymphoma Diagnosis and Treatment
- Connective tissue disorders research
- Kruppel-like factors research
McGill University Health Centre
2014-2025
McGill University
2016-2023
Université de Montréal
2016
Montreal Heart Institute
2016
Objective— The mechanisms underlying the pathogenesis of aortic valve calcification remain unclear. With accumulating evidence demonstrating that recapitulates bone development, crucial roles noncanonical Wnt ligands WNT5a, WNT5b, and WNT11 in osteogenesis make them critical targets study calcification. Approach Results— Using immunohistochemistry, real-time qPCR, Western blotting, tissue culture, we examined distribution noncalcified calcified valves their effects on human interstitial...
C ardiovascular diseases remain the primary cause of death. 1 Myocardial infarction (MI), angina, and stroke take >16 million lives every year, but underlying mechanisms by which these often-fatal cardiovascular events occur tend to escape attention. 2Atherosclerosis is pathological inflammatory vascular disease not only responsible for most MIs strokes, it accounts 29% deaths worldwide. 1,34][5] Atherosclerosis characterized accumulation lipids, fibrous elements, cells within wall medium...
Longitudinal clinic supervision is complex but key to training residents, such as endocrinology residents. Supervisors report difficulties providing learners with the right balance of and autonomy. Cognitive apprenticeship theory applies teaching in workplace-based settings, longitudinal clinic. While this identifies effective strategies for supervising medical students little known about how why supervisors adapt their when offering To understand supervisors' perspectives on residents over...
Background and aims: The aims of the present study were to determine expression urotensin II (UII), urotensin-II related peptide (URP) their receptor (UT) in stable unstable carotid atherosclerosis, effects UII on human aortic smooth muscle cell (SMCs) calcification. Methods Results: We examined UII, URP UT protein 88 endarterectomy specimens using immunohistochemistry. Expression was more evident compared plaques (P<0.05). Multivariate Spearman correlation analyses revealed significant...
Several previous studies outlined the importance of histone H2A deubiquitinase MYSM1 in regulation stem cell quiescence and haematopoiesis. In this study we investigated role T-cell development. Using mouse models that allow conditional Mysm1 ablation at late stages thymic development, found is intricately involved maintenance, activation survival CD8+ T cells. resulted a twofold reduction numbers, also led to hyperactivated state accompanied by impaired proliferation increased...
Abstract Disclosure: I. Albanese: None. N. Nicolas: S.S. Wing: Grant Recipient; Self; Pfizer Global R&D. Other; Almac Discovery (Independent Contractor). E. Mitmaker: L. Vautour: Background: Primary hyperparathyroidism is rarely diagnosed in pregnancy as symptoms may overlap with those of and biochemical diagnosis be masked by physiologic changes calcium homeostasis. Hyperparathyroidism associated increased maternal fetal complications. While mild disease treated conservatively, moderate...
Although retinoid-associated central hypothyroidism has been reported on several occasions, there are very few studies adrenal insufficiency. Here, we present the case of a patient with alitretinoin-induced and insufficiency.An 86-year-old man diagnosis cutaneous T-cell lymphoma, treated oral alitretinoin 30 mg po daily, topical steroids, ultraviolet light therapy presented to emergency department generalized weakness, decreased energy, orthostasis, unexplained falls. Thyroid-stimulating...
Prader-Willi syndrome (PWS) is associated with multiple endocrinopathies, including hypogonadism. The mechanism underlying hypogonadism in PWS thought to be secondary hypothalamic dysfunction, primary gonadal defect, or a combination of both. Here, we present case hyperestrogenism due concomitant polycystic ovary (PCOS) and therapeutic considerations regarding hormone replacement therapy (HRT).An 18-year-old woman transferred adult care from pediatrics was found have (specifically, elevated...
Introduction: Atherosclerosis is a leading cause of death in Western societies. Vasoactive peptide urotensin II (UII) upregulated atherosclerosis and several other cardiovascular diseases however further research required to develop complete understanding UII’s role the pathogenesis atherosclerosis. Hypothesis: We hypothesized that UII stimulates calcification vascular smooth muscle cells UII, related (URP) UT receptor expression are calcified aortic valves. Methods Results: Human (HASMC)...
Introduction: The mechanisms underlying the pathogenesis of aortic valve calcification remain unclear. With accumulating evidence demonstrating that recapitulates bone development, crucial roles non-canonical Wnt ligands Wnt5b and Wnt11 in osteogenesis make them critical targets study calcification. Hypothesis: We hypothesized signaling mediated by is upregulated expression these molecules may be associated with pathological calcium deposition valves. Methods Results: Mitral, non-calcified...
Abstract Background: Pregnancy is associated with physiological increased resistance to insulin, leading insulin requirements for diabetic women. Poor glycemic control in pregnancy neonatal and maternal complications. Insulin has been traditionally administered subcutaneously through multi daily injections (MDIs) however, use of pumps or continuous subcutaneous infusion (CSII) become more widespread. As direct influence on perinatal outcomes, comparing MDIs CSII pregnant women Type 1...