A5008058854- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Orthopedic Surgery and Rehabilitation
- MRI in cancer diagnosis
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Musculoskeletal synovial abnormalities and treatments
- Ultrasound Imaging and Elastography
- Pancreatitis Pathology and Treatment
- Musculoskeletal Disorders and Rehabilitation
- Diagnosis and Treatment of Venous Diseases
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Diet and metabolism studies
- Elasticity and Material Modeling
- Shoulder Injury and Treatment
- Foot and Ankle Surgery
- Tendon Structure and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Pediatric Hepatobiliary Diseases and Treatments
Université Paris Cité
2020-2025
Hôpital Beaujon
2018-2025
Assistance Publique – Hôpitaux de Paris
2018-2025
Sorbonne Paris Cité
2024
Inserm
2020-2023
Centre de Recherche sur l'Inflammation
2020-2023
Maastricht University Medical Centre
2023
Centre National de la Recherche Scientifique
2021
University of Genoa
2013-2018
Abstract Objectives To develop and evaluate a deep convolutional neural network (DCNN) for automated liver segmentation, volumetry, radiomic feature extraction on contrast-enhanced portal venous phase magnetic resonance imaging (MRI). Materials methods This retrospective study included hepatocellular carcinoma patients from an institutional database with MRI. After manual the data was randomly split into independent training, validation, internal testing sets. From collaborating institution,...
Background Both Liver Imaging Reporting and Data System (LI-RADS) histopathologic features provide prognostic information in patients with hepatocellular carcinoma (HCC), but whether LI-RADS is independently associated survival uncertain. Purpose To assess the association of categories outcomes solitary resected HCC. Materials Methods This retrospective study included HCC from three institutions examined preoperative contrast-enhanced CT and/or MRI between January 2008 December 2019. Three...
Purpose To determine whether quantification of liver surface nodularity (LSN) provides an estimate the presence clinically significant portal hypertension (CSPH) in patients with cirrhosis. Materials and Methods This retrospective study included a training cohort (n = 189) separate external validation 78), both composed cirrhosis who underwent abdominal CT hepatic venous pressure gradient (HVPG) measurement between 2010 2016. The LSN score, spleen volumes, liver-to-spleen volume ratio,...
To evaluate the predictive value of lipiodol retention pattern for local progression HCC with a complete response (CR) on CT according to mRECIST criteria after first session conventional chemoembolization (cTACE).From January 2014 May 2016 all consecutive patients undergoing cTACE were identified. Inclusion presence ≤3 HCCs and available pre- post-cTACE CT. Tumor was classified criteria. The analysis focused tumors CR. in these as (C-Lip, covering entire tumor volume), or incomplete...
To assess the performance of CT-based radiomics analysis in differentiating benign from malignant intraductal papillary mucinous neoplasms pancreas (IPMN), preoperative scans 408 resected patients with IPMN were retrospectively analyzed. IPMNs classified as (low-grade dysplasia, n = 181), or (high grade, 128, and invasive, 99). Clinicobiological data reported. Patients divided into a training cohort (TC) 296 an external validation (EVC) 112 patients. After semi-automatic tumor segmentation,...
Porto-sinusoidal vascular disorder (PSVD) is a rare and commonly overlooked cause of portal hypertension. The interest CT analysis, including quantification liver surface nodularity (LSN) for PSVD diagnosis has not been established. This study aimed at assessing the performance LSN features in patients with signs hypertension.This retrospective case-control included learning cohort consisting 50 histologically proven PSVD, according to VALDIG criteria, 100 control cirrhosis, matched on...
With the development of chemotherapy regimens, targeted therapies, and hepatic surgery, survival patients with colorectal liver metastases (CRLM) has dramatically improved. Imaging plays a central role for diagnosis, staging, treatment allocation in these patients. To interpret CRLM on imaging, radiologists must be familiar main imaging features untreated tumors as well modifications induced by systemic their meaning relation to pathological tumor response biology. have same histological...
Abstract Background Quantification of liver surface nodularity (LSN) on routine preoperative CT images allows detection cirrhosis and clinically significant portal hypertension. This study aimed to assess the relevance LSN in assessment operative risks for patients with resectable hepatocellular carcinoma (HCC). Methods All undergoing hepatectomy HCC between 2012 2017 were analysed retrospectively. was assessed at liver–fat interface left lobe images. The feasibility quantification assessed....
We compare the performance of liver surface nodularity (LSN) and stiffness measurements (LSM) using transient elastography (TE) for detection clinically significant portal hypertension (CSPH) in patients with cirrhosis hepatocellular carcinoma (HCC).All HCC who underwent computed tomography, LSM hepatic venous pressure gradient (HVPG) within 30 days between 2015 2018 were included. The estimation CSPH by LSN LSM, LSM-spleen-size-to-platelet ratio score (LSPS) evaluated compared.In total, 140...
Posthepatectomy liver failure (PHLF) is a rare but dreaded complication. The aim was to test whether combination of non-invasive biomarkers (NIBs) and CT data could predict the risk PHLF in patients who underwent resection hepatocellular carcinoma (HCC).Patients with HCC had between 2012 2020 were included. A relevant NIBs (NIB model) model identified using doubly robust estimator (inverse probability weighting combined logistic regression). adjustment variables body surface area, ASA...
Abstract Background and Aim The study aims to assess the influence of pretreatment tumor growth rate (TGR) on modified response evaluation criteria in solid tumors (mRECIST) objective (OR) after a first session selective transarterial chemoembolization (TACE) for treatment hepatocellular carcinoma (HCC). Methods One hundred fifteen patients (101 men [88%], mean 65.1 ± 10.5 years [range 26–87]) with 169 (mean 34.2 29.3 mm [10–160]), undergoing TACE HCC between 2011 2016, were included. TGR...
To investigate whether fractal analysis of perfusion differentiates hepatocellular adenoma (HCA) subtypes and carcinoma (HCC) in non-cirrhotic liver by quantifying chaos using four-dimensional dynamic contrast-enhanced magnetic resonance imaging (4D-DCE-MRI).A retrospective population 63 patients (47 female) with histopathologically characterized HCA HCC livers was investigated. Our consisted 13 hepatocyte nuclear factor (HNF)-1α-inactivated (H-HCAs), 7 β-catenin-exon-3-mutated (bex3-HCAs),...