A5061726312- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Issues in Pregnancy
- Heparin-Induced Thrombocytopenia and Thrombosis
- Systemic Lupus Erythematosus Research
- Hemoglobinopathies and Related Disorders
- Vascular anomalies and interventions
- Neurosurgical Procedures and Complications
- Hemophilia Treatment and Research
- Dermatological and Skeletal Disorders
- Peptidase Inhibition and Analysis
- Case Reports on Hematomas
- Liver Disease and Transplantation
- Galectins and Cancer Biology
- Meta-analysis and systematic reviews
- Reproductive Health and Contraception
- Retinal Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Gut microbiota and health
- Connective tissue disorders research
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2012-2024
Ospedale Maggiore
2004-2020
University of Milan
2004-2018
Ospedale L. Bonomo
2014
High platelet to lymphocyte ratio (PLR) and neutrophil (NLR) are associated with an increased risk of arterial thrombosis, but their role in venous thromboembolism (VTE) has not been fully investigated. A case-control study, 486 patients VTE, 100 cerebral vein thrombosis (CVT), 299 healthy individuals, was carried out investigate whether high PLR or NLR values VTE. Patients did have VTE (odds [OR] 0.89, 95% confidence interval [CI]: 0.46-1.76; OR: 0.69, CI: 0.34-1.39, respectively) CVT (OR:...
A bleeding diathesis is a common feature of Noonan syndrome, and various coagulation abnormalities have been reported. Platelet function has never carefully investigated.The degree in cohort patients with syndrome was evaluated by validated score investigated platelet tests. If ratios prothrombin time and/or activated partial thromboplastin were prolonged, the activity clotting factors measured. Individuals no history formed control group.The study population included 39 28 controls....
Background The anti-phospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with persistent presence of antibodies (aPL). Laboratory criteria include aPL detection coagulation tests for lupus anticoagulant (LAC) or solid phase assays measuring anti-β2 glycoprotein I (aβ2GPI) anti-cardiolipin (aCL) immunoglobulin (Ig) G/IgM antibodies. External quality control programs illustrate that commercially available produce variable results. Objective We aimed to...
Lumbar puncture (LP) is rarely complicated by cerebral vein thrombosis (CVT), especially if other risk factors coexist. We describe the case of a 28-year-old woman who developed CVT after corticosteroid treatment and LP performed for suspected multiple sclerosis. The day LP, she intense headache on Day 8 generalized tonic-clonic seizures. A brain computed tomography scan showed superior sagittal sinus cortical veins. Thrombophilia screening heterozygous G20210A prothrombin mutation....
Patients with severe forms of von Willebrand's disease (VWD) may have frequent episodes mucocutaneous bleeding and also hemarthrosis or hematomas. However, little retrospective prospective data on secondary long term prophylaxis in VWD are available. Aim this study was to evaluate the efficacy safety fixed regimens factor VIII/VWF concentrates our cohort patients recurrent joint gastrointestinal (GI) bleeds. This is a 452 enrolled database until December 2004. 89/452 cases (20%) were treated...
Nephrotic syndrome confers an acquired prothrombotic phenotype due to the urinary loss of anticoagulant proteins.Patients with reactivation nephrotic may develop thrombosis. We report case a life-threatening cerebral venous thrombosis in 13 year-old boy affected by relapse during P. aeruginosa otitis/mastoiditis. Due worsening general conditions and severe neurological impairment, course systemic thrombolysis was successfully administered, followed therapy. In present inherited thrombophilia...