A5089142128- Maternal and Perinatal Health Interventions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Maternal and fetal healthcare
- Cardiovascular Function and Risk Factors
- Parathyroid Disorders and Treatments
- Pregnancy-related medical research
- Preterm Birth and Chorioamnionitis
- Prenatal Screening and Diagnostics
- Pelvic floor disorders treatments
- Cardiac Valve Diseases and Treatments
- Fetal and Pediatric Neurological Disorders
- Medical Imaging and Pathology Studies
- Healthcare Systems and Practices
- Pregnancy and preeclampsia studies
- Cardiomyopathy and Myosin Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Genomic variations and chromosomal abnormalities
- Cardiac Structural Anomalies and Repair
- Hip and Femur Fractures
- Ectopic Pregnancy Diagnosis and Management
- Corneal Surgery and Treatments
- Health, Medicine and Society
- Bone health and osteoporosis research
- Pulmonary Hypertension Research and Treatments
- Plant Pathogens and Fungal Diseases
Hôpital Rangueil
2017-2024
Inserm
2014-2024
Institut des Maladies Métaboliques et Cardiovasculaires
2021-2024
Université de Toulouse
2019-2022
Institute of Cardiology
2021
Imagerie et Cerveau
2021
Société Française de Cardiologie
2021
Centre Hospitalier Universitaire de Toulouse
2021
Centre Hospitalier Universitaire de Lille
2020
Centre Hospitalier Universitaire de Bordeaux
2005-2019
Abstract Our study aimed to assess the prevalence of post-traumatic stress disorder (PTSD) after childbirth one year vaginal delivery and identify characteristics women deliveries associated with it. Questionnaires were mailed a 1103 prospectively collected postpartum data, including question on day 2 assessing their experience childbirth. PTSD was assessed later by Impact Event Traumatic Scales; 22 (4.2%, 95%CI 2.7–6.3%) met diagnostic criteria 30 (5.7%; 3.9–8.0%) profile criteria. Factors...
Early diagnosis of cardiac involvement is a key issue in the management AL amyloidosis. Our objective was to establish diagnostic score amyloidosis and compare it with current consensus criteria [i.e. left ventricular hypertrophy >12 mm N-terminal pro b-type natriuretic peptide (NT-proBNP) >332 ng/L].We carried out prospective multicenter study on patients who underwent evaluation including clinical examination, electrocardiography (ECG), biomarkers, transthoracic echocardiography (TTE),...
Cyclic adenosine monophosphate (cAMP) is a master regulator of mitochondrial metabolism but its precise mechanism action yet remains unclear. Here, we found that dietary saturated fatty acid (FA), palmitate increased intracellular cAMP synthesis through the palmitoylation soluble adenylyl cyclase in cardiomyocytes. further induced exchange protein directly activated by cyclic AMP 1 (Epac1) activation, which was upregulated myocardium obese patients. Epac1 enhanced activity key enzyme...
Abstract The aim of our study was to assess the feasibility implementing a protocol for use magnesium sulfate prevent cerebral palsy. This retrospective single-center included all women with fetuses gestational age <33 weeks gestation whose birth planned or expected within 24 hours from September 2011 December 2012. They were receive sulfate, administered intravenously as 4-g bolus followed by constant infusion 1 g per hour. If delivery had not occurred after 12 and no longer considered...
Objective To evaluate the effect of fetal head station at attempted operative vaginal delivery (aOVD), and specifically midpelvic or low aOVD, on female male sexual function symptoms postpartum depression (PPD) 6 months. Design Prospective population-based cohort study. Setting 1,941 women with singleton term fetuses in vertex presentation aOVD between 2008 2013 a tertiary care university hospital. Methods Symptoms dysfunction using Pelvic Organ Prolapse/Urinary Incontinence/Sexual Function...
Pregnancy-associated placental protein-A (PAPP-A) is a metalloprotease which circulates as an hetero-tetramer in maternal blood. Its serum concentration fetal trisomy 21 decreased during the first trimester, so that PAPP-A useful screening biomarker. However, regulation of secretion unclear. We therefore investigated pregnancies complicated by aneuploidies, both vivo and vitro. Maternal collected between 10 WG 33 7014 normal 96 21, 18, 13 were assayed for using Immulite 2000xpi system®. The...
Abstract Tissue engineering chambers (TECs) bring great hope in regenerative medicine as they allow the growth of adipose tissue for soft reconstruction. To date, a wide range TEC prototypes are available with different conceptions and volumes. Here, we addressed influence design on fat flap vivo well possibility using bioresorbable polymers optimum conception. In rats, is quicker under perforated printed polylactic acid than non-perforated ones (growth difference 3 to 5 times greater within...
Abstract Postpartum hemorrhage (PPH) is one of the most common causes mortality in obstetrics worldwide. The accuracy estimated blood loss a priority determining appropriate treatment. Will additional use visual aid improve physicians’ estimating compared to collector bag and baby scale alone? Simulation training sessions created three vaginal delivery scenarios for participants estimate volumes loss: firstly, using only weight secondly, adding depicting known blood. primary endpoint was...
Objective: Postpartum hemorrhage (PPH) is one of the most common causes mortality in obstetrics worldwide. Accuracy estimated blood loss a priority determining appropriate treatment. The aim this study was to evaluate accuracy estimating by care providers during simulated training sessions.Method: A prospective occurred 2013 maternity ward at teaching hospital. Simulation sessions recreated vaginal delivery which six different scenarios were presented and proposed each participant for them...
Abstract The aim of our study was to assess the theoretical and practical knowledge French obstetricians about surgical management postpartum haemorrhage (PPH). Our is a national anonymous self-administered survey. A total 363 responded this questionnaire between December 2013 April 2014. Questionnaire sent through email all who are members either two federations hospital-based obstetricians. Answers were collected until end June main outcome measure obstetricians’ level mastery each...
The aging heart is characterized by a number of structural changes leading to ventricular stiffness, impaired resistance stress and increased risk developing failure (HF). Genetic or pharmacological removal senescent cells has recently demonstrated the possibility relieve some cardiac features such as hypertrophy fibrosis. However, contribution different cell types in remains fragmentary due lack cell-specific markers. Cardiomyocytes undergo post-mitotic senescence response telomere damage,...
We aimed to compare different methods for semi-quantitative analysis of cardiac retention bone tracers in patients with transthyretin amyloidosis (ATTR).Data from 67 ATTR who underwent both conventional whole-body scan and a CZT myocardial SPECT (DSPECT, Spectrum Dynamics) 3 h after injection 99mTc-labeled tracer were analyzed. Visual scoring was performed on according Perugini 4-point grading system 0 (no uptake) (strong uptake mild/absent uptake). A planar heart-to-background (H:B) ratio...
Aims To phenotype patients referred to a tertiary centre for the exploration of left ventricular hypertrophy (LVH) starting from 12 mm wall thickness (LVWT). Methods and results Consecutive aetiological workup LVH, beginning at LVWT were retrospectively included in this single-centred observational study. Patients presenting with severe aortic stenosis excluded. Aetiological was reviewed each subject aetiologies adjudicated by expert consensus. Among 591 LVH workup, 41% had maximal below 15...
To validate and evaluate the performance metrics of high-throughput semiconductor sequencing platform, Ion Proton®, in non-invasive prenatal genetic screening (NIPS) for common fetal aneuploidies a clinical setting.This prospective cohort study included 2505 pregnant women from eight academic genetics laboratories (695 high risk trisomy 21 (risk ≥ 1/250) pregnancies validation study, 1810 such pregnancies, without ultrasound anomalies, real-life NIPS setting). Outcome was available all cases...
Abstract Objective The aim of this study is to evaluate the diagnostic utility prenatal diagnosis using chromosomal microarray analysis (CMA) for fetuses presenting with isolated or associated intrauterine growth restriction (IUGR). Method We retrospectively included all IUGR referred testing and studied by rapid fluorescence in situ hybridization (FISH), karyotype, CMA. Results Among 162 (78 84 IUGR) included, 15 had an abnormal FISH result: 10 five fetal IUGRs. 143 CMA, (7%) presented...