A5038538088- Mesenchymal stem cell research
- Surgical Simulation and Training
- Reconstructive Surgery and Microvascular Techniques
- Anatomy and Medical Technology
- Genital Health and Disease
- Effects of Radiation Exposure
- Head and Neck Cancer Studies
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Cancer Diagnosis and Treatment
- Wound Healing and Treatments
- Systemic Sclerosis and Related Diseases
- Diversity and Career in Medicine
- Oral Health Pathology and Treatment
- Dermatologic Treatments and Research
- Augmented Reality Applications
- Body Contouring and Surgery
- Digital Imaging in Medicine
- Tracheal and airway disorders
- Tissue Engineering and Regenerative Medicine
- Orthopedic Surgery and Rehabilitation
- Cancer Cells and Metastasis
- Cardiac, Anesthesia and Surgical Outcomes
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
The Royal Free Hospital
2019-2024
University College London
2016-2024
Wolfson Foundation
2024
Royal Free London NHS Foundation Trust
2021-2024
South Tees Hospitals NHS Foundation Trust
2023
Imperial College Healthcare NHS Trust
2019-2020
Imperial College London
2018-2020
University College Hospital
2016
Autologous fat transfers show promise in treating fibrotic skin diseases, reversing scarring and stiffness, improving quality of life. Adipose-derived stem cells (ADSCs) within these grafts are believed to be crucial for this effect, particularly their secreted factors, though the specific mechanisms remain unclear. This study investigates transcriptomic changes ADSCs after vitro fibrotic, inflammatory, hypoxic conditioning. High-throughput gene expression assays were conducted on exposed...
Background Non-thermal non-tumescent methods for varicose vein treatment have rapidly gained popularity in recent years due to clinical efficacy comparable other endovenous methods, but with a superior safety and tolerability profile. Cyanoacrylate is an adhesive that polymerises during cause rapid occlusion of veins initiate fibrosis. Method glue known complications such as phlebitis, cellulitis deep thrombosis rare instances. We present the first reported case cyanoacrylate extravasation...
Adipose-derived stem cells (ADSCs) as part of autologous fat grafting have anti-fibrotic and anti-inflammatory effects, but the exact mechanisms action remain unknown. By simulating interaction ADSCs with fibroblasts endothelial (EC) from scleroderma (SSc) skin in silico, we aim to unravel these mechanisms. Publicly available single-cell RNA sequencing data stromal vascular fraction 3 lean patients biopsies 10 control 12 SSc were obtained GEO analysed using R Seurat. Differentially expressed...
Peripheral nerve injuries in children are uncommon and can be challenging to diagnose. There is a paucity of data on long-term sensorimotor functional outcomes following surgical repair. We present 12-year retrospective analysis pediatric peripheral repair with outcomes.
A national, multi-centre audit of non-melanoma skin cancer excisions by plastic surgery.
Surgical fixation of Bennett's fracture the thumb is critical to prevent functional impairment; however, there no consensus on optimal method. We performed an 11-year retrospective cohort analysis and a systematic literature review determine long-term patient-reported outcomes following fixation. Retrospective identified 49 patients treated with Kirschner (K)-wire fixation, 85% returned unrestricted movement during hand therapy. Forty-seven (96%) completed disabilities arm, shoulder, (DASH)...
Simulation training provides an important opportunity to accelerate surgical skills acquisition whilst safeguarding patients. This study compares the suitability of different synthetic skin substitutes for use in simulation training.Data was collected eight commercially available and included cost, delivery time, subjective assessment fidelity by surgeons trainees, objective comparison with biomechanics human made through cutometry durometry measurements. Cutometry data from three healthy...
Abstract A 45‐year‐old female patient presented to clinic with an almost completely embedded ring in the volar aspect of her right finger, complete reepithelialisation over superficial ring. We present this unusual case after insect bite on patient's finger. The had worn for previous 5 years without removing it and did not report any discomfort or traumatic injury. discuss context previously reported cases ring, a rare presentation itself, highlighting key differences both aetiology risk...