A5102807371- Fibromyalgia and Chronic Fatigue Syndrome Research
- Spondyloarthritis Studies and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Bone and Joint Diseases
- Genomics and Phylogenetic Studies
- Ultrasound Imaging and Elastography
- Lung Cancer Diagnosis and Treatment
- Algorithms and Data Compression
- Advanced MRI Techniques and Applications
- Pneumonia and Respiratory Infections
- Pleural and Pulmonary Diseases
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Hepatitis B Virus Studies
- Rheumatoid Arthritis Research and Therapies
- Cystic Fibrosis Research Advances
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Wind Energy Research and Development
- Gene expression and cancer classification
- Ocular Diseases and Behçet’s Syndrome
Cyprus University of Technology
2013-2024
General Hospital of Ioannina G. Hatzikosta
2024
Babeș-Bolyai University
2023-2024
National Observatory of Athens
2023
Nicosia General Hospital
2014-2023
University College London
2022
Frederick University
2022
Royal Free London NHS Foundation Trust
2022
The Royal Free Hospital
2022
ETH Zurich
2019
Understanding how molecular changes caused by genetic variation drive disease risk is crucial for deciphering mechanisms. However, interpreting genome sequences challenging because of the vast size human genome, and its consequences manifest across a wide range cells, tissues scales -- spanning from to whole organism level. Here, we present Phenformer, multi-scale language model that learns generate mechanistic hypotheses as differences in sequence lead disease-relevant expression cell types...
<h3>BACKGROUND:</h3> Patients with nursing home acquired pneumonia (NHAP) present a distinct group of lower respiratory track infections different risk factors, clinical presentation, and mortality rates. <h3>OBJECTIVES:</h3> To evaluate the diagnostic value pulmonary infection score (CPIS), C-reactive protein, procalcitonin to compare accuracy severity scores (confusion, urea nitrogen, breathing frequency, blood pressure, ≥ 65 y age [CURB-65]; index; NHAP systolic multilobar involvement,...
In chronic hepatitis C and non-alcoholic fatty liver disease, apoptotic caspases are activated in liver, serum caspase activity has been suggested as a sensitive marker of early injury. An investigation was carried out into whether the levels caspase-generated fragments cytokeratin-18 (CK-18) associated with severity lesions B e antigen (HBeAg)-negative virus (HBV) infection. Patients/CK-18 fragment were determined 115 treatment-naive, consecutive HBV patients 30 healthy controls....
Abstract In this article, a decision analysis methodology for wind energy resource assessment and development is developed applied to the Larnaca District in Cyprus. The consists of five steps: (i) formulation geo-data base with Wind Atlas Analysis Application Program; (ii) establishment constraint factors that would exclude sites from further examination; (iii) evaluation criteria possible sites; (iv) weights through Analytic Hierarchy Process; (v) aggregation Simple Additive Weighting...
1. World Health Organization. Tobacco. Key Facts. 2014 [cited December 16]; Available from: http://goo.gl/o05e9F. Accessed 16 Dec 2014. Google Scholar
Introduction: Little information exists in the general population whether clinical presentation phenotypes of obstructive sleep apnea (OSA) differ terms quality and comorbidities. Aim: The purpose our study was to assess possible differences between symptomatic asymptomatic OSA patients concerning syndrome's severity, patients' quality, Subjects methods: First, a nationwide, stratified, epidemiological survey, 4,118 Cypriot adult participants were interviewed about habits complaints. In...
Summary The kinetics of serum HB sAg and interferon‐inducible protein 10 ( IP 10) levels in patients with chronic hepatitis B infection treated tenofovir are unclear. We evaluated the changes predictability for decline 160 eAg‐negative receiving ≥12 months. Serum samples taken before at 6, 12, 24, 36 48 months after were tested levels. In 104 patients, Compared to tenofovir, decreased by a median 0.08, 0.11, 0.24, 0.33 0.38 log IU / mL months, respectively P < 0.001). did not differ...
Abstract Background and objective Medical thoracoscopy (MT) is useful for the management of pleural disease. Rapid on‐site evaluation (ROSE) transbronchial needle aspirates proved to be during bronchoscopy. We aimed evaluate diagnostic performance ROSE MT biopsy specimens thoracoscopists' impression macroscopic appearance assess intermodality agreement between final histopathologic diagnosis. Methods Sixty two patients with exudative effusions further investigated were enrolled. was...
The purpose of this study was to investigate the intra-rater reliability and agreement handgrip strength (HGS) measurement using a hydraulic hand dynamometer in patients with chronic obstructive pulmonary disease (COPD). A sample 19 COPD (18 males 1 female; mean ± SD age, 66.9 6.3 years) evaluated by same rater two different testing sessions 7-d interval. During each session, were asked exert three maximal isometric contractions on dominant value 3 efforts (measured kilogram-force [Kgf])...
Asthma is one of the main non-infectious diseases respiratory system with substantial economic burden worldwide. The objective this study was to estimate adult asthma in Cyprus during 2015. A retrospective probabilistic prevalence-based cost illness model developed calculate including direct and indirect costs. bottom-up approach (person-based data) used for calculation costs while human capital employed. In addition, bootstrapped sensitivity analysis 1000 bootstrap simulations performed...
The impact of psychiatric illnesses upon asthma patients' functioning is not well understood. This study examined the comorbidity illness management in patients using empirically-derived groups. Participants were a clinic sample Greek-speaking (N = 212) assessed Patient Health Questionnaire (PHQ) Somatoform, Depression, Panic Disorder (PD), Other Anxiety Disorder, Eating (ED) and Alcohol sub-scales. associations between sub-scales multiway frequency analysis. following groups derived:...
Background: The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in Cyprus is largely unknown. aim the study was to estimate COPD through a spirometry population- based program and identify certain disease characteristics Cypriot population. Methods: performed 1,233 randomly selected individuals covering representative urban rural areas. Inclusion criteria were: age ≥ 35 years old lifetime smoking history at least 100 cigarettes. Participants answered detailed questionnaire...
Abstract Background The current study proposes simple methods for assessing the performance of robotic devices intended Magnetic Resonance Imaging (MRI)‐guided needle biopsy. Methods In‐house made agar‐based breast phantoms containing biopsy targets served as main tool in evaluation process an MRI compatible positioning device comprising a navigator. motion accuracy mechanical stages was assessed by calliper measurements. Laboratory targeting included repeatability phantom test and...
We present a case of 58 years old man with large heterogeneous and well circumscribed soft tissue mass arising from the right pleural surface, found at computer tomography his chest. This after complete resection through lateral open thoracotomy, proved to be Solitary Fibrous Tumor, previously known as 'benign mesothelioma'. tumor is usually discovered routine chest X-rays since patients are either asymptomatic or report atypical symptoms. Only 10–20% published cases malignant solitary...
YKL-40 is an extracellular matrix glycoprotein with a significant role in tissue inflammation and remodeling. MIP-1a has chemotactic pro-inflammatory properties, induced by several lung disorders. The aim of this study was to determine the levels blood serum pleural fluids various pulmonary diseases, evaluate their potential as differential diagnosis biomarkers.We recruited 60 patients (age: 62.5 ± 20.6 years) effusions: 49 exudates 11 transudates (T). Exudates were further classified based...
Purpose: Pulmonary rehabilitation (PR) including exercise training improves muscle strength, capacity, and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). However, the evidence effect upper limb (ULET) on activities daily living (ADL) is sparse. This study investigated two different types ULET ADL addition to standard PR. Methods: Patients were randomly assigned a strength or combined group. Both groups exercised 2 d/wk for 12 wk. Outcome...
High-quality methods for Magnetic Resonance guided Focussed Ultrasound (MRgFUS) therapy planning are needed safe and efficient clinical practices. Herein, an algorithm full coverage path based on preoperative MR images is presented.The software functionalities of MRgFUS robotic system were enhanced by implementing the developed algorithm. The algorithm's performance in accurate following a Zig-Zag pathway was assessed images. planned sonication paths performed acrylic films using carrying...
A national, multi-centre audit of non-melanoma skin cancer excisions by plastic surgery.