The main objective of this study was to remove amyloid β plaques by applying multiple sessions focused ultrasound (US)-induced blood-brain barrier (BBB) opening using microbubbles with and without delivery antibodies in a rabbit model.The animal model achieved feeding high-cholesterol diet rabbits for 4 months. Fifty-two New Zealand White were divided into treatment groups: untreated control, only, US antibodies. Three administered the groups.It shown that model, 30 μm diameter. By...

This study describes the development and characterization of an agar-based soft tissue-mimicking material (TMM) doped with wood powder destined for fabricating MRgFUS applications. The main objective following work was to investigate suitability as inexpensive alternative in replacing other added materials that have been suggested previous studies controlling ultrasonic properties TMMs. procedure involved a series experiments designed estimate acoustic (attenuation coefficient, absorption...

It has been demonstrated that agar-based gel phantoms can emulate the acoustic parameters of real tissues and are most commonly used tissue-mimicking materials for high-intensity focused ultrasound applications. The following study presents ultrasonic attenuation measurements with different concentrations additives (percent agar, silicon dioxide evaporated milk) in an effort matching material's property as close possible to human tissues.Nine various amounts dioxide, milk were prepared....

A robotic system for Magnetic Resonance guided Focussed Ultrasound (MRgFUS) therapy of tumours in the breast, bone, thyroid, and abdomen was developed.A special C-shaped structure designed to be attached table conventional magnetic resonance imaging (MRI) systems carrying 4 computer-controlled motion stages dedicated positioning a 2.75 MHz spherically focussed transducer relative patient placed supine position. The developed evaluated its MRI compatibility heating abilities agar-based...

Abstract Background A magnetic resonance image (MRI) guided robotic device for focussed ultrasound therapy of prostate cancer (PC) was developed. The offers movement in 5 degrees freedom (DOF) and uses a single‐element transducer that operates at 3.2 MHz, has diameter 25 mm focuses 45 mm. Methods MRI compatibility the system evaluated 1.5 T scanner. ability to create lesions laboratory settings, on ex vivo pork tissue rabbit thigh tissue. Results Cavitational thermal were created excised In...

With focused ultrasound (FUS) gaining popularity as a therapeutic modality for brain diseases, the need skull phantoms that are suitable evaluating FUS protocols is increasing. In current study, acoustical properties of several three-dimensional (3D) printed thermoplastic samples were evaluated to assess their suitability mimic human and bone accurately. Samples 3D using eight commercially available materials. The acoustic samples, including attenuation coefficient, speed sound, impedance,...

Abstract Background A prototype robotic system that uses magnetic resonance guided focused ultrasound (MRgFUS) technology is presented. It features three degrees of freedom (DOF) and intended for thermal ablation abdominal cancer. Methods The device equipped with identical transducers being offset between them, thus focussing at different depths in tissue. efficacy safety the ablating rabbit liver kidney was assessed, both laboratory imaging (MRI) conditions. Results Despite these organs'...

A robotic device featuring three motion axes was manufactured for preclinical research on focussed ultrasound (FUS). The comprises a 2.75 MHz single element ultrasonic transducer and is guided by Magnetic Resonance Imaging (MRI).The compatibility of the with MRI evaluated estimating influence signal-to-noise ratio (SNR). efficacy in generating ablative temperatures phantoms excised porcine tissue.System's activation scanner reduced SNR to an acceptable level without compromising image...

A magnetic resonance image (MRI) guided robotic system dedicated for brain biopsy was developed. The carries a needle and small rectangular unfocused, single element, planar ultrasonic transducer which can be potentially utilized to ablate localized cancer.The device includes six computer-controlled axes. An agar-based phantom developed included an olive that mimics target. operated at 4 MHz used.The functionality of the assessed by means ultrasound imaging, MRI MR thermometry, demonstrating...

Abstract Background Robotic‐assisted diagnostic and therapeutic modalities require a highly accurate performance to be certified for clinical application. In this paper, three simple methods assessing the accuracy of motion magnetic resonance‐guided focused ultrasound (MRgFUS) robotic systems are presented. Methods The 4 degrees freedom system intended preclinical use MRgFUS was evaluated by calliper‐based resonance imaging (MRI) methods, as well visually performing multiple ablations on...

Background: In this article, a medical robotic system that performs magnetic resonance imaging-guided focused ultrasound surgery ablation is presented. The main innovation of all the actuators are placed outside water container. transducer immersed in through an arm which attached to angular stage. Materials and Methods: includes three linear one device uses piezoelectric motors for each motion accuracy was achieved with optical encoders. A operated at 1 MHz radius curvature 10 cm diameter 4...

Objectives A positioning device compatible with magnetic resonance imaging (MRI) used for preclinical studies in small animals was developed that fits MRI scanners up to 7 T. The designed two computer‐controlled linear stages. Methods evaluated an agar‐based phantom, which mimics soft tissues, and a rabbit. Experiments this were performed system using the phantom. transducer had diameter of 50 mm, operated at 0.5 MHz, focused energy 60 mm. Results Magnetic thermometry assess functionality...

Focussed Ultrasound (FUS) combined with microbubbles (MBs) was proven a promising modality for non-invasive blood brain barrier disruption (BBBD). Herein, two devices FUS-mediated BBBD in rodents are presented.A two-axes robotic device manufactured navigating single element FUS transducer of 1 MHz relative to the rodents. A second more compact featuring motorized vertical axis also developed. Their performance assessed terms motion accuracy, MRI compatibility and trans-skull wild type mice...

Magnetic resonance-guided focused ultrasound surgery is an incisionless energy-based thermal method that used for ablating tumors in the veterinary clinic.In this article we describe a prototype of system compatible with magnetic resonance imaging intended small-to-medium-sized companion animals was developed and tested vivo adult rabbits.Real-time monitoring ablation during experiment possible MR thermometry. Experiments involved sonications applied thigh rabbits. A 38-mm diameter...

Abstract Background The current study proposes simple methods for assessing the performance of robotic devices intended Magnetic Resonance Imaging (MRI)‐guided needle biopsy. Methods In‐house made agar‐based breast phantoms containing biopsy targets served as main tool in evaluation process an MRI compatible positioning device comprising a navigator. motion accuracy mechanical stages was assessed by calliper measurements. Laboratory targeting included repeatability phantom test and...

Abstract Background A magnetic resonance imaging (MRI) compatible robotic system for focused ultrasound was developed small animal like mice or rats that fits into a 9.4 T MRI scanner (Bruker Biospec 9420, Bruker Biospin, Ettlingen, Germany). The includes two computer‐controlled linear stages. Materials and Methods evaluated in mouse‐shaped, real‐size agar‐based mimicking material, which has similar acoustical properties as soft tissues. agar content 6% weight per volume (w/v), 4% w/v silica...

Background: A magnetic resonance image (MRI)-guided robotic system dedicated for prostate cancer (PC) was produced that carries a small spherically focused, single-element, ultrasonic transducer which can be potentially utilized endorectally. Materials and Methods: The developed device utilizes four computer-controlled axes. An agar-based phantom developed, included cavity mimics the rectum geometry. Experiments with were performed in 1.5T MRI using gel phantom. has diameter of 18 mm,...

ABSTRACT Objectives: This article describes novel magnetic resonance imaging (MRI)-compatible focused ultrasound robotic systems and agar-based MRI-compatible ultrasonic phantoms mimicking bone. Materials Methods: All the were developed using three-dimensional (3D) printing technology plastic material. The tissue surrounding bone in was mimicked solutions. Results: presents MRI-guided for brain, prostate, gynecological targets. It also reports on breast, bone, motion. Conclusions: popular 3D...

Background: The main goal of the study was to find magnetic resonance imaging (MRI) parameters that optimize contrast between tissue and thermal lesions produced by focused ultrasound (FUS) using T1-weighted (T1-W) T2-weighted (T2-W) fast spin echo (FSE) sequences. Methods: FUS sonications were performed in ex vivo porcine a single-element transducer 2.6 MHz 1.5 3 T MRI scanners. difference relaxation times as well impact critical on resultant contrast-to-noise ratio (CNR) coagulated normal...

Background: The current study presents the development of a magnetic resonance imaging (MRI)-compatible silicone-based 3D printer capable producing patient-specific implants within MRI scanners. Methods: printing device incorporates 3 piezoelectrically-actuated linear motion stages assigned for navigating custom-made silicone extruder to develop desired model based on preoperative scans damaged anatomy. structural components were manufactured rapid prototyping machine with thermoplastic and...