A5023630736- Stress Responses and Cortisol
- Gut microbiota and health
- Hormonal and reproductive studies
- Tryptophan and brain disorders
- Sexual function and dysfunction studies
- Neuroendocrine regulation and behavior
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Menopause: Health Impacts and Treatments
- Air Quality Monitoring and Forecasting
- Air Quality and Health Impacts
- Sexual Differentiation and Disorders
- Atmospheric chemistry and aerosols
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Estrogen and related hormone effects
- Dermatology and Skin Diseases
- Hypothalamic control of reproductive hormones
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Urinary Bladder and Prostate Research
- Cancer Treatment and Pharmacology
- Sexuality, Behavior, and Technology
University of Milan
2021-2024
The RHAPS (Redox-Activity And Health-Effects Of Atmospheric Primary Secondary Aerosol) project was launched in 2019 with the major objective of identifying specific properties fine atmospheric aerosol from combustion sources that are responsible for toxicological effects and can be used as new metrics health-related outdoor pollution studies. In this paper, we present overall methodology introduce phenomenology first data observed. A comprehensive physico-chemical characterization has been...
Patients affected by diabetes mellitus (DM) show diabetic encephalopathy with an increased risk of cognitive deficits, dementia and Alzheimer's disease, but the mechanisms are not fully explored. In male animal models DM, development impairment seems to be result concomitance different processes such as neuroinflammation, oxidative stress, mitochondrial dysfunction, aberrant synaptogenesis. However, even if shows some sex-dimorphic features, no observations in female rats have been so far...
Sex steroids, derived mainly from gonads, can shape microbiota composition; however, the impact of gonadectomy and sex on steroid production in gut (i.e., steroids), its interaction with composition, needs to be clarified. In this study, environment steroidogenesis were analysed by liquid chromatography tandem mass spectrometry expression analyses. Gut composition as branched- short-chain fatty acids determined 16S rRNA gene sequence analysis gas flame ionisation detection, respectively....
An important aspect of the neuromodulatory and neuroprotective actions exerted by neuroactive steroids is that they are sex-specific, as determined sexually dimorphic levels these molecules in plasma nervous tissue. Thus, identification factors generate sex-dimorphic may be crucial from a neuroprotectant perspective. The main driver for sex determination mammals SRY gene subsequent presence specific gonad: testes males ovaries females, thus producing hormonal compounds, primarily androgens...
Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) L-DOPA-induced dyskinesias (LIDs). We recently reported that 5α-reductase (5AR) inhibitors dampen parkinsonian rats; however, unraveling which specific mediates this effect is critical to optimize a targeted therapy. Among the 5AR-related neurosteroids, striatal pregnenolone has been shown be increased response 5AR blockade decreased after 6-OHDA lesions rat PD model. Moreover,...
Post-finasteride syndrome and post-SSRI sexual dysfunction, are two poorly explored clinical conditions in which men treated for androgenetic alopecia with finasteride or depression SSRI antidepressants show persistent side effects despite drug suspension (e.g., psychological complaints, sleep disorders). Because of some similarities the symptoms, common pathological mechanisms proposed here. Indeed, as discussed, studies preclinical data obtained so far suggest an important role brain...
Neuroactive steroids (i.e., sex steroid hormones and neurosteroids) are important physiological regulators of nervous function potential neuroprotective agents for neurodegenerative psychiatric disorders. Sex is an component such effects. However, even if fluctuations in hormone level during the menstrual cycle associated with neuropathological events some women, neuroactive pattern brain across ovarian has been poorly explored. Therefore, we assessed levels pregnenolone, progesterone, its...
Steroid hormones are essential biomolecules for human physiology as they modulate the endocrine system, nervous function and behaviour. Recent studies have shown that gut microbiota is directly involved in production metabolism of steroid periphery. However, influence on levels steroids acting present brain (i.e., neuroactive steroids) not fully understood. Therefore, using liquid chromatography-tandem mass spectrometry, we assessed several various areas plasma germ-free (GF) male mice...
Abstract Despite its efficacy for treating androgenetic alopecia, finasteride, an inhibitor of 5α‐reductase (i.e., the enzyme converting testosterone, T, into dihydrotestosterone, DHT), is associated with several side effects including sexual dysfunction (e.g., erectile dysfunction). These may persist after drug suspension, inducing so‐called post‐finasteride syndrome (PFS). The subchronic treatment finasteride 20 days) and withdrawal 1 month) in rat corpus cavernosum have been explored...
The treatment with finasteride (i.e., an inhibitor of 5α-reductase) may be associated different side effects depression, anxiety, cognitive impairment and sexual dysfunction) inducing the so-called post syndrome (PFS). Moreover, previous observations in PFS patients experimental model showed alterations gut microbiota populations, suggesting inflammatory environment. To confirm this hypothesis, we have explored effect chronic for 20 days) its withdrawal 1 month) on levels steroids,...
The pathological consequences of type 2 diabetes mellitus (T2DM) also involve the central nervous system; indeed, T2DM patients suffer from learning and memory disabilities with a higher risk developing dementia. Although several factors have been proposed as possible contributors, how neuroactive steroids gut microbiome impact brain pathophysiology in remain unexplored. On this basis, male Zucker diabetic fatty (ZDF) rats, we studied whether alters abilities using novel object recognition...
Neuroactive testosterone metabolites synthesized by enzymes 5α-reductase and 3α/3β-hydroxysteroid oxidoreductase are critical physiological modulators of the central nervous system (CNS) function. Indeed, as discussed in this review, they exert a variety effects on myelination, brain maturation, neurotransmission, reproductive behavior, stress responses. The expression synthesis these well levels derivatives exhibit specific localized regional sex differences CNS influenced under various...
The RHAPS project was launched in 2019 with the major objective to identify specific properties of fine atmospheric aerosol from combustion sources that are responsible for toxicological effects and can be used as new metrics health-related outdoor pollution studies. In this paper, we present overall methodology RHAPS, introduce phenomenology first data observed. A comprehensive physico-chemical characterization has been achieved by means high-time resolution measurements (e.g. number size...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)