A5033738124- Gut microbiota and health
- Renal and related cancers
- Sarcoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Ovarian cancer diagnosis and treatment
- Medical Imaging and Pathology Studies
- Particle Detector Development and Performance
- Teratomas and Epidermoid Cysts
- Spinal Dysraphism and Malformations
- Advanced X-ray and CT Imaging
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Medical Imaging Techniques and Applications
- Digestive system and related health
- Tuberous Sclerosis Complex Research
- Restraint-Related Deaths
- Appendicitis Diagnosis and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Bone Tumor Diagnosis and Treatments
- Advanced Semiconductor Detectors and Materials
- Renal cell carcinoma treatment
- Genetic and Kidney Cyst Diseases
- Urological Disorders and Treatments
- Ear Surgery and Otitis Media
Centre Hospitalier Universitaire de Besançon
2017-2024
Hôpital Privé Jean Mermo
2024
Biocodex (France)
2023
Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est
2015-2020
Microbiologie de l’alimentation au service de la santé
2014-2020
AgroParisTech
2015-2020
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020
Université Paris-Saclay
2020
Université de franche-comté
2015-2019
Centre National de la Recherche Scientifique
1983-2016
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified on the basis of human clinical data. The mechanisms underlying its beneficial effects are still unknown. Gnotobiotic mice harboring F. (A2-165) and Escherichia coli (K-12 JM105) were subjected to 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute colitis. inflammatory colitis scores a gas chromatography-time flight (GC/TOF) mass spectrometry-based metabolomic profile monitored in blood, ileum, cecum,...
The commensal bacterium Faecalibacterium prausnitzii plays a key role in inflammatory bowel disease (IBD) pathogenesis and serves as general health biomarker humans. However, the host molecular mechanisms that underlie its anti-inflammatory effects remain unknown. In this study we performed transcriptomic approach on human intestinal epithelial cells (HT-29) stimulated with TNF-α exposed to F. culture supernatant (SN) order determine impact of cells. Moreover, modulation most upregulated...
Originally designed as a new nuclear reactor monitoring device, the Nucifer detector has successfully detected its first neutrinos. We provide second-shortest baseline measurement of neutrino flux. The detection electron antineutrinos emitted in decay chains fission products, combined with core simulations, provides tool to assess both thermal power and fissile content whole could be used by International Agency for Atomic Energy enhance safeguards civil reactors. Deployed at only 7.2 m away...
Crystallization of the poorly durable Na 2 MoO 4 phase able to incorporate radioactive cesium must be avoided in SiO –Al O 3 –B –Na O–CaO glasses developed for immobilization Mo‐rich nuclear wastes. Increasing amounts B and were added a glass, crystallization tendency was studied. decreased with increase concentration whereas CaMoO crystallize increased due preferential charge compensation BO − entities by + ions. 29 Si MAS NMR showed that molybdenum acts as reticulating agent glass...
Ovarian teratoma (OT) is the most common ovarian neoplasm in children. Oophorectomy has been standard treatment but may impair fertility. The aim of this study was to investigate feasibility and outcome ovarian-sparing surgery (OSS) for OT.We retrospectively studied all children treated OT at a pediatric teaching hospital Paris, France, between March 1992 July 2006. OSS performed when deemed technically feasible patients who had no lymphadenopathy by preoperative imaging or surgical...
To evaluate the frequency of ovarian torsion in neonates with cysts (OCs) and to analyze outcome after surgical treatment.A retrospective review all infants OCs managed our institution during 20 years, was conducted. Our management included a follow-up (FU) prenatal serial ultrasound (US) scan without cyst aspiration early postnatal US scan. Neonatal surgery indicated for that appeared complex regardless size simple larger than mm.Sixty-seven detected through diagnosis were identified. Cysts...
By describing 10 new patients recruited in centres for Human Genetics, we further delineate the clinical spectrum of a Crouzon‐like craniosynostosis disorder, officially termed and dental anomalies (MIM614188). Singularly, it is inherited according to an autosomal recessive mode inheritance. We identified six missense mutations IL11RA, gene encoding alpha subunit interleukin 11 receptor, 4 them being novel, including 2 Ig‐like C2‐type domain. A subset had associated connective tissue...
Heterozygous mutations in TCF12 were recently identified as an important cause of craniosynostosis. In the original series, 14% patients with a mutation had significant developmental delay or learning disability. We report on first case microdeletion, detected by array‐comparative genomic hybridization, 72‐year‐old patient presenting intellectual deficiency and dysmorphism. Multiplex ligation‐dependent probe amplification analysis indicated that exon 19, encoding functionally basic...
Heterozygous mutations of TCF2 (transcription factor 2) have been associated with maturity onset diabetes the young, renal malformations, hyperuricemia, and occasionally internal genital malformations in female. We report a female patient bilateral hypodysplasia de novo heterozygous gene mutation. At age 9 yr, she developed transient ketoacidosis immediately posttransplant, temporarily requiring insulin. During glucocorticoid tapering, impaired glucose tolerance persisted overt...
Irritable bowel syndrome (IBS) is one of the disorders most frequently diagnosed by gastroenterologists. Probiotics are promising tools for management IBS. The objective present study was to evaluate effectiveness and tolerability a probiotic (Bifidobacterium longum 35624®) in adults (aged 18 or over) with IBS (as defined Rome IV criteria). In an open-label, observational, post-market conducted Germany, prior recommendation intake B. 35624® were recruited family physicians. During 8-week...
Thick (200 to 500 /spl mu/m) epitaxial GaAs layers have been grown on two inch wafers by using a chemical reaction technique which is inexpensive, nonpolluting, and allows very high growth rates. X-ray detectors made of p/i/n structures realized nonintentionally doped n/sup +/ substrates, with the p/sup layer at surface obtained ion implantation. These validated current capacitance-voltage measurements, photocurrent induced irradiation, energy resolution measurements. The data demonstrate...