This study was designed to evaluate the effects of purple potato extract Blue Congo variety (PP) on diabetes and its antioxidant activities after two-week administration tostreptozotocin (STZ)-induced diabetic rats. The PP were evaluated at a dose 165 mg/kg body weight (b.w.) by estimating biochemical changes in blood plasma through histopathological kidney, muscles, liver tissue. We effect treatment with glucose level, glycated hemoglobin, enzymatic antioxidants (including superoxide...

The relationship between the structure and antiradical antioxidant activities of three anthocyanidins, namely peonidin, petunidin, delphinidin, their glucosides was investigated in this study. ability anthocyanins to scavenge free radicals determined using DPPH● assay, whereas inhibition peroxidation liposomes relation a model membrane that imitated composition lipid tumor cells specified fluorimetric method. To explore issue at atomistic level, density functional theory studies were...

Quercetin (Q) was used as substrate for regioselective glycosylation at the C-7 position catalyzed by Beauveria bassiana AM278 strain. As a result glycoside quercetin 7-O-β-d-(4″-O-methyl)glucopyranoside (Q 7-MeGlu) formed. The goal of studies to determine anti-oxidative (liposome membrane protection against free radicals IC50Q 7-MeGlu = 5.47 and 4.49 µM) anti-inflammatory (COX-1 COX-2 enzymes activity inhibition) properties Q compared Q. Every attempt made clarify antioxidant these...

The study of ethanol extracts as potential dietary supplements has shown that chokeberry (IC 50 24.6 μg/mL) and, to a lesser extent, blackcurrant, rosehip, and hawthorn 30.9, 33.5, 45.9 are good antioxidants in relation UVB‐oxidized phosphatidylcholine liposomes. All tested fruit protect the bilayer against oxidation by reducing fluidity membrane hydrophilic/hydrophobic region (in presence generalized polarization Laurdan probe fluorescence anisotropy DPH TMA‐DPH increased). major phenolic...

The synthesis of different classes prenylated aglycones (α,β-dihydroxanthohumol (2) and (Z)-6,4'-dihydroxy-4-methoxy-7-prenylaurone (3)) was performed in one step reactions from xanthohumol (1)-major chalcone naturally occurring hops. Obtained flavonoids (2-3) (1) were used as substrates for regioselective fungal glycosylation catalyzed by two Absidia species Beauveria bassiana. As a result six glycosides (4-9) formed, which four (6-9) have not been published so far. influence flavonoid...

The aim of the study was to determine in vitro biological activity fruit ethanol extract from Chaenomeles speciosa (Sweet) Nakai (Japanese quince, JQ) and its important constituents (−)-epicatechin (EC) chlorogenic acid (CA). also investigated structural changes phosphatidylcholine (PC) liposomes, dipalmitoylphosphatidylcholine erythrocyte membranes (RBC) induced by extract. It found that effectively inhibits oxidation RBC, 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH), PC UVB...

Abstract This study focuses on understanding the structural and molecular changes in lipid membranes under influence of six halogenated flavonoid derivatives differing number position substitution chlorine bromine atoms (D1–D6). Utilizing various analytical techniques, including fluorometric methods, dynamic light scattering (DLS), attenuated Fourier transform infrared spectroscopy (ATR- FTIR), FT-Raman spectroscopy, research aims to elucidate mechanisms underlying interaction flavonoids...

We investigated the effects of acylated cyanidin-3-O-β-(6″-O-E-p-coumaroyl-sambubioside)-5-O-β-glucoside (C3-cs-5G) and nonacylated cyanidin, cyanidin-3,5-di-O-β-glucoside (C3,5G) cyanidin-3-O-β-glucoside (C3G), on cell-mimic membranes (MM) that reflected membrane lipid composition tumor cells. The relationship between structural derivatives cyanidin (Cy-d), interactivity, their antioxidant activity, interaction with albumin were characterized. Studies showed Cy-d caused an increase in...

Abstract The aim of the study was to compare impact three synthesized chemical compounds from a group methylated flavonoids, i.e. 2′-hydroxy-4-methylchalcone ( 3 ), 4′-methylflavanone 4 and 4′-methylflavone 5 on red blood cell membranes (RBCMs), phosphatidylcholine model (PC), human serum albumin (HSA) in order investigate their structure–activity relationships. In first stage study, it proved that all tested do not cause hemolysis cells and, therefore, have toxic effect. biophysical...

Although extracts are broadly used in order to support the treatment of numerous diseases, only a limited number cases is process applying and establishing their mechanisms action scientifically analyzed. Fruits Cornelian cherry an abundant source iridoids, anthocyanins, flavonols phenolic acids. The aim present study was evaluate vitro bioactivity red yellow fruits' extracts. biological potential extracts, broad sense, involved antioxidant activity relation phosphatidylcholine liposomes,...

In our research we used the extract from dietary supplement of elderberry (EE) and its dominant anthocyanin—cyanidin 3-O-glucoside (Cy 3-gluc). By interacting with a model membrane that reflects main lipid composition tumor membranes, components, including Cy 3-gluc, caused an increase in packing order, mainly hydrophilic region membrane. It can thus be stated EE rigidifying effect, which is fundamental for understanding anticancer antioxidant activity. This study represents first attempt to...

1. Optimizing conditions for antioxidant phenolic compound extraction from Mahonia bealei (Fort.) Carr. leaves using a response surface methodology Lei Wu, Gongcheng Wang, Ting Shen, Long You, Weicheng Hu, Chuan-Ling Si Horticulture, Environment, and Biotechnology CrossRef

Buckwheat is a valuable source of many biologically active compounds and nutrients. It has properties that reduce blood cholesterol levels, so reduces the risk atherosclerosis, seals capillaries, lowers pressure. The aim study was to determine quantitative qualitative characteristics polyphenols contained in extracts from buckwheat husks stalks, biological activity extracts, biophysical effects their interaction with erythrocyte membrane, treated as model cell. An analysis extract's...

The biological activity of Blue Congo extract has been explained at the cellular, lipid membrane and biomolecular levels.

The aim of the study is to investigate differences in interaction three structurally diverse anthocyanidins, namely peonidin, petunidin, and delphinidin, as well their glucosides with model biological membranes, human albumin, plasmid DNA order look into structure-activity relationships. Fluorimetric studies, ATR-FTIR analyses, were jointly used determine changes observed both hydrophilic hydrophobic layers cell-mimic membranes (MM) which reflected membrane lipid composition tumour cells red...

In this study we focused on the chemical composition, antioxidant, anti-inflammatory and antibacterial properties of methanol water extracts fruits six species grown in south-west Poland: blackberry, blackcurrant, chokeberry, cherry, gooseberry raspberry. No general correlation could be drawn between extract (i.e. antioxidant free radical scavenging) observed biological effects. However, blackcurrant blackberry (both water) appeared to good antioxidants scavengers, as well effective...

The antioxidative and antiradical properties of malvidin (Mv), 3-O-glucoside (Mv 3-glc) 3,5-O-diglucoside 3,5-diglc) were evaluated by AAPH● DPPH● assays, respectively. In both cases, a decrease in activity was observed the following order Mv > 3-glc 3,5-diglc. Quantum mechanics studies have confirmed this pattern, which can be explained an underlying based on hydrogen atom transfer from C3-hydroxyl. Further measurements ability malvidins to interact with membrane-mimicking liposomes...

Background.Extracts from the Rosaceae family fruits are rich in natural, biologically active polyphenols, but their antibacterial properties still poorly understood.Therefore, we focused our research on activity against uropathogenic Escherichia coli strains.This also concerned proof of ability to reduce oxidative stress and modulate lipoxygenase-1 (LOX-1).It is well-known that plants represent a source bioactive compounds whose antioxidant may be useful protecting damage cells, which have...

We obtained red wine concentrate, which was enriched with natural polyphenolic compounds (PC concentrate). The main purpose to study the hypoglycemic and antioxidant effects of its impact on key hematological parameters rats experimental diabetes mellitus. While administrating concentrate diabetes, partial recovering glucose tolerance promoted, as well normalization glycated hemoglobin level, an increase in quantity erythrocytes concentration. PC had anti-radical effect, determined using...

Malvidin, one of the six most prominent anthocyanins found in various fruits and vegetables, may possess a wide range health-promoting properties. The biological activity malvidin its glycosides is not entirely clear has been relatively less frequently studied compared to other anthocyanins. Therefore, this study aimed determine relationship between structural derivatives their anti-cholinergic anti-inflammatory activity. selected (Mv) two sugar derivatives: 3-O-glucoside (Mv 3-glc)...

This study aimed to determine the biological activity of Rosa rugosa Thunb. extracts in four versions: methanolic (ME), diethyl ether (EE), ethyl acetate (EA) and water (WE). We studied antioxidant relation phospholipid membranes, their association constants with membrane, antiradical anti-inflammatory activity. Percentage liposomal encapsulation was also assessed. R. ME EA were observed decrease peroxidation PC liposomes (UVC-induced) similar levels (ME) or lower compared canina L. The...

In times of worsening civilization diseases the interest in natural healing substances is on increase. To reduce unwanted side effects many synthetic drugs, it reasonable to introduce daily diet foods rich compounds plant origin that are beneficial for health. The purpose study was determine biological activity and stability selected ethanol extracts fruit chokeberry, blackcurrant, hawthorn, rosehip, quince Japanese as potential nutraceuticals.Antioxidant determined relation model...

<title>Abstract</title> This study focuses on understanding the structural and molecular changes in lipid membranes under influence of six halogenated flavonoid derivatives differing number position substitution chlorine bromine atoms (D1-D6). Utilizing various analytical techniques, including fluorometric methods, dynamic light scattering (DLS), attenuated Fourier transform infrared spectroscopy (ATR- FTIR), Raman spectroscopy, research seeks to elucidate mechanisms underlying interaction...