A5016118127- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Identification and Quantification in Food
- Computational Drug Discovery Methods
- Genetic Mapping and Diversity in Plants and Animals
- Aquaculture Nutrition and Growth
- Fish Ecology and Management Studies
- Neuroscience and Neural Engineering
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Fish Biology and Ecology Studies
- Attention Deficit Hyperactivity Disorder
- Microbial Natural Products and Biosynthesis
- Respiratory viral infections research
- Algorithms and Data Compression
- Machine Learning in Bioinformatics
- Developmental Biology and Gene Regulation
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Hippo pathway signaling and YAP/TAZ
- Invertebrate Immune Response Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Pharmaceutical and Antibiotic Environmental Impacts
Beijing Normal University
2024
Xiamen University
2016-2023
Chinese Institute for Brain Research
2023
Xiamen University of Technology
2021-2023
Chinese Academy of Fishery Sciences
2012-2018
Shanghai Ocean University
2014-2016
Heilongjiang Center for Tuberculosis Control and Prevention
2013
Bowdoin College
1975
High density genetic linkage maps are essential for QTL fine mapping, comparative genomics and high quality genome sequence assembly. In this study, we constructed a high-density high-resolution map with 28,194 SNP markers on 14,146 distinct loci common carp based high-throughput genotyping the 250 K single nucleotide polymorphism (SNP) array in mapping family. The length of consensus was 10,595.94 cM an average locus interval 0.75 marker 0.38 cM. Comparative genomic analysis revealed level...
Abstract Identifying new lead molecules to treat cancer requires more than a decade of dedicated effort. Before selected drug candidates are used in the clinic, their anti-cancer activity is generally validated by vitro cellular experiments. Therefore, accurate prediction response critical and challenging task for drugs design precision medicine. With development pharmacogenomics, combination efficient feature extraction methods omics data has made it possible use computational models assist...
The Amur ide (Leuciscus waleckii) is a cyprinid fish that widely distributed in Northeast Asia. Lake Dali Nur population inhabits one of the most extreme aquatic environments on Earth, with an alkalinity up to 50 mmol/L (pH 9.6), thus providing exceptional model which characterize mechanisms genomic evolution underlying adaptation environments. Here, we developed reference genome assembly for L. waleckii from Nur. Intriguingly, identified unusual expanded long terminal repeats (LTRs) higher...
The interaction between microribonucleic acid and long non-coding ribonucleic plays a very important role in biological processes, the prediction of one is great significance to study its mechanism action. Due limitations traditional experiment methods, more computational methods are applied this field. However, existing often have problems, such as inadequate acquisition potential features sequence due simple coding need manually extract input. We propose deep learning model, preMLI, based...
To identify quantitative trait loci (QTL) that affect body shape in common carp Cyprinus carpio , a linkage map, 2159·23 cM long, was constructed with total of 307 markers covering 51 groups (LG). The map included 167 new single nucleotide polymorphism (SNP) derived from expressed sequence tags (EST) together 140 microsatellite reported earlier. A primary genome scan conducted for QTL standard length ( L S ), head H height B width W ) and tail TAIL an F1 line containing 92 offspring. 15...
In humans, the frizzled (FZD) gene family encodes 10 homologous proteins that commonly localize to plasma membrane. Besides being associated with three main signaling pathways for cell development, most FZDs have different physiological effects and are major determinants in development process of vertebrates and. Here, we identified annotated FZD genes whole-genome common carp (Cyprinus carpio), a teleost fish, determined their phylogenetic relationships other vertebrates. Our analyses...
Various salmonid species are cultivated in cold water aquaculture. However, due to limited genomic data resources, specific high-throughput genotyping tools not available many of the species. In this study, a 57K single nucleotide polymorphism (SNP) array for rainbow trout (Oncorhynchus mykiss) was utilized detect polymorphisms seven species, including Hucho taimen, Oncorhynchus masou, Salvelinus fontinalis, Brachymystax lenok, leucomaenis, O. kisutch, and mykiss. The number polymorphic...
A pharmacokinetic and tissue residue study of sulfadiazine combined with trimethoprim ( SDZ / TMP = 5/1) was conducted in Siniperca chuatsi after single‐ (120 mg/kg) or multiple‐dose (an initial dose 120 mg/kg followed by a 5‐day consecutive 60 oral administrations at 28 °C. The absorption half‐life t 1/2 α ), elimination β volume distribution (V d /F), the total body clearance (Cl B /F) for were 4.3 ± 1.7 to 6.3 1.8 h 2.4 1.0 3.9 0.9 h, 25.9 4.5 53.0 5.6 11.8 3.5 17.1 3.4 2.34 0.78 3.67...
Bioactive peptides are defined as peptide sequences within a protein that can regulate important bodily functions through their myriad activities. With the development of machine learning, more computational methods were proposed for bioactive recognition so this task does not only rely on tedious and time-consuming wet-experiment. But training testing process existing models limited to small datasets, which affects model performance. Inspired by success sequence classification in natural...
Abstract The stimulant methylphenidate (MPH) and the non-stimulant atomoxetine (ATX) are frequently used for treatment of attention-deficit/hyperactivity disorder (ADHD); however, function these drugs in different types brain cells their effects on related genes remain largely unknown. To address questions, we built a pipeline simultaneous examination activity behavior transcriptional responses Drosophila melanogaster at single-cell resolution following drug treatment. We selected with...
The complete mitochondrial genome of the first individual Rhinogobio typus collected from Yellow River were sequenced and compared with previously reported sequence Yangtze River. length their circular was determined to be 16 599 608 bp respectively. comparison two genomes revealed 237 base pair substitutions 17 insertions or deletions (indels), including 182 2 indels in protein-coding region. Phylogenetic tree constructed based on mitogenomes populations closely related 13 teleost species...
Abstract DNA molecules, as natural information carriers, have several benefits over conventional digital storage mediums, including high density and long-term durability. It is expected to be a promising candidate for storage. However, despite significant research in this field, the pace of development has been slow due lack complete encoding-decoding platform simulaton-evaluation system. And mutation sequences during synthesis sequencing requires multiple experiments, wet experiments can...
The complete mitochondrial genomes of two ornamental fishes, black molly (Poecilia sphenops) and blue gourami (Trichogaster trichopterus), were obtained by the traditional polymerase chain reaction (PCR)-based sequencing approach. mitogenomes P. sphenops T. trichopterus are determined as 16,533 bp 16,456 in length, respectively. Both include 22 transfer RNA genes, 13 protein-coding genes 2 ribosomal genes. Phylogenetic tree was constructed based on these species closely related 20 teleost to...
Yellowfin goby (Acanthogobius hasta) belongs to the Perciformes Gobiidae. In this study, we sequenced complete mitochondrial genome of A. hasta. The was determined be 16,663 bp in length including 13 protein-coding genes, 22 transfer RNAs (tRNAs), 2 ribosomal (rRNAs) and 1 control region. gueldenstaedti provides basic data for relative studies on Acipenseriformes.
PDF HTML阅读 XML下载 导出引用 引用提醒 国内虹鳟代表性养殖群体的高通量SNP芯片检测及遗传分析 DOI: 作者: 作者单位: 1. 中国水产科学研究院, 农业部水生动物基因组学重点实验室, 渔业生物技术北京市重点实验室, 北京 100141;2. 中国水产科学研究院黑龙江水产研究所, 黑龙江 哈尔滨 150070;3. 四川农业大学 动物科技学院, 四川 雅安 625014;4. National Center for Cool and Cold Water Aquaculture, ARS-USDA, Kearneysville, WV 25430, USA;5. 厦门大学 海洋与地球学院, 福建省海洋生物资源开发利用协同创新中心, 福建 厦门 361102 作者简介: 赵紫霞(1983-),女,博士,副研究员,从事水产生物技术研究. 通讯作者: 中图分类号: S917 基金项目: 国家科技支撑计划项目（2015BAD25B01）；中国水产科学研究院基本科研业务费专项（2015C007）. Genome-wide genetic analysis of...
<title>Abstract</title> The stimulant methylphenidate (MPH) and the non-stimulant atomoxetine (ATX) are frequently used for treatment of attention-deficit/hyperactivity disorder (ADHD); however, function these drugs in different types brain cells their effect on related genes remain largely unknown. To address questions, we built a pipeline simultaneous examination activity behavior transcriptional responses <italic>Drosophila melanogaster</italic> at single-cell resolution following drug...