A5103070245- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Management and Placebo Effect
- Long-Term Effects of COVID-19
- Treatment of Major Depression
- Child and Adolescent Psychosocial and Emotional Development
- Intensive Care Unit Cognitive Disorders
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Mental Health Research Topics
- Pain Mechanisms and Treatments
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Perfectionism, Procrastination, Anxiety Studies
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Sleep and related disorders
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Respiratory Support and Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Cardiac Arrest and Resuscitation
- Transcranial Magnetic Stimulation Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Frailty in Older Adults
- Neural and Behavioral Psychology Studies
University of Southampton
2015-2025
Isle of Wight NHS Trust
2025
Southern Health NHS Foundation Trust
2019-2024
National Health Service
2021-2024
Dorset HealthCare University NHS Foundation Trust
2024
Imperial College London
2022-2024
University of Oxford
2017-2023
NIHR Leicester Biomedical Research Centre
2023
University of Leicester
2023
University Hospitals of Leicester NHS Trust
2023
Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials innovative therapeutic interventions. However, an explicit definition treatment-resistant anxiety (TR-AD) informing such is currently lacking. We used Delphi method-based consensus approach to provide internationally agreed, consistent clinically useful operational criteria for TR-AD in adults. Following summary the current...
Transcranial direct current stimulation (tDCS) is a non-invasive form of neurostimulation with potential for development as self-administered intervention. It has shown promise safe and effective treatment obsessive compulsive disorder (OCD) in small number studies. The two most favourable targets appear to be the left orbitofrontal cortex (L-OFC) supplementary motor area (SMA). We report first study test these head-to-head within randomised sham-controlled trial. Our aim was inform design...
Importance Expectancy effects are significant confounding factors in psychiatric randomized clinical trials (RCTs), potentially affecting the interpretation of study results. This narrative review is first, to our knowledge, explore relationship between expectancy effects, compromised blinding integrity, and active treatment/placebo RCTs. Additionally, we present statistical experimental approaches that may help mitigate impact effects. The concludes with recommendations enhance reliability...
The lack of clear understanding the pathophysiology chronic pain could explain why we currently have only a few effective treatments. Understanding how relief is realised during placebo analgesia help develop improved treatments for pain. Here, tested whether experimental was associated with altered resting-state cortical activity in alpha frequency band electroencephalogram (EEG). Alpha oscillations been shown to be influenced by top-down processes, which are thought underpin response....
Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect later mood improvement. However, less is known about on reward despite potential relevance to treatment anhedonia. In study, we investigated effects an acute dose atypical antidepressant (dual dopamine noradrenaline reuptake inhibitor) bupropion behavioural measures healthy volunteers. Methods: 40...
Abstract Background Anxiety disorders are highly prevalent and socio-economically costly. Novel pharmacological treatments for these needed because many patients do not respond to current agents or experience unwanted side effects. However, a barrier treatment development is the variable large placebo response rate seen in trials of novel anxiolytics. Despite this, mechanisms that drive responses anxiety have been little investigated, possibly due low availability convenient experimental...
Interoception is defined as the sense of internal state body. Dysfunctions in interoception are found several mental disorders, including trauma-related conditions. Mindfulness-Based Interventions (MBIs) have been shown to influence interoceptive processes. Randomised controlled trials (RCTs) investigated whether MBIs impact symptoms and patients with disorders. We undertook a systematic review meta-analysis synthesize these data. included RCTs an MBI arm which enrolled adult trauma...
Placebo-controlled trials are the gold standard measure of efficacy in development new treatments for depression. However, large placebo effects associated with measures subjective symptoms reduce sensitivity such to detect antidepressant effects. There is a need develop novel markers that resistant Measures emotional processing, known be sensitive treatment, may marker, although effect an acute treatment on these remains unclear. We assessed influence validated battery processing tasks,...
Patients with learning disabilities are not always involved in decision-making about their medications. This may mean that some patients unfairly denied of autonomy. We carried out an audit current practice concerning consent to treatment against best guidelines. Data were collected via a questionnaire given sample 70 within the Salford catchment area. assessed whether regarding medications and they being enough information give informed consent. A total 45 completed questionnaires. Overall,...
Anxiety disorders constitute the most common group of psychiatric with a lifetime prevalence 14.5–33.7%. Despite effective pharmacological and psychological treatments, first line treatment is often not effective, development new therapies needed. One area interest orexin system, neurotransmitter system based in lateral hypothalamus widespread projections throughout brain, including to several key areas involved modulation fear anxiety. In this article, we summarise findings from...
The 7.5% CO2 inhalational model can be used to explore potential treatments for generalized anxiety disorder. However, it is unknown how inter-individual variability in the functional architecture of negative affective valence systems might relate anxiogenic response this model.A total 13 healthy volunteers underwent magnetic resonance imaging during a passive emotional face perception task. We explored task-evoked connectivity threat system through psychophysiological interaction analysis....
Social anxiety disorder (SAD) is very common and can be significantly disabling. New treatments are needed as the remission rate for SAD lowest of all disorders. Experimental medicine models, in which features resembling a clinical experimentally induced, cost-effective timely approach to explore potential novel psychiatric Following emergence SARS-CoV-2, there need develop experimental models that carried out remotely. We developed procedure investigate (the InterneT-based Stress test...
Abstract Background Obsessive–compulsive disorder (OCD) is a neuropsychiatric which often proves refractory to current treatment approaches. Transcranial direct stimulation (tDCS), noninvasive form of neurostimulation, with potential for development as self-administered intervention, has shown safe and efficacious OCD in small number trials. The two most promising sites are located above the orbitofrontal cortex (OFC) supplementary motor area (SMA). Methods aim this feasibility study inform...