A5054062963- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Autism Spectrum Disorder Research
- Transcranial Magnetic Stimulation Studies
- Body Image and Dysmorphia Studies
- Treatment of Major Depression
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Eating Disorders and Behaviors
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Mental Health Treatment and Access
- Electroconvulsive Therapy Studies
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Tryptophan and brain disorders
- Pain Management and Treatment
- Suicide and Self-Harm Studies
- Child Development and Digital Technology
- Neurological disorders and treatments
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Adolescent and Pediatric Healthcare
- Neuroendocrine regulation and behavior
- COVID-19 and Mental Health
University of Milan
2016-2025
ASST Fatebenefratelli Sacco
2019-2025
Luigi Sacco Hospital
2019-2024
Jazz Pharmaceuticals (Italy)
2020-2024
Association for Language Learning
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2010-2019
Stanford University
2016-2019
Ospedale Maggiore
2014-2019
University of Southampton
2016
University of Milano-Bicocca
2016
After the outbreak of Coronavirus disease was declared a pandemic by World Health Organization, this resulted in extraordinary public health measures to control infection, such as entire countries being placed under quarantine. The psychopathological consequences and quarantine were anticipated be particular relevance, especially patients with psychiatric disorders Obsessive Compulsive Disorder (OCD). Aim present report describe impact COVID-19 pandemics within sample Italian affected OCD....
Transcranial direct current stimulation (tDCS) is a selective, painless, brain technique that allows the electric of specific cortical regions. TDCS has been recently used as investigational intervention for major depression and treatment resistant (TRD) with encouraging results. The present study was aimed to investigate efficacy tolerability tDCS in depressives poor response pharmacological treatment. Twenty-three depressed patients, diagnosis depressive disorder or bipolar disorder, were...
Objective: Many studies suggest that age at onset (AAO) is an important factor for clinically differentiating patients with juvenile and adult of obsessive–compulsive disorder (OCD). The present international study aimed to assess the prevalence different AAO groups compare related socio-demographic clinical features in a large sample OCD patients.Methods: A total 431 outpatients, participating ICOCS network, were first categorised childhood (≤12 years), adolescent (13–17 years) adult-onset...
The latency to first pharmacological treatment (duration of untreated illness or 'DUI') is supposed play a major role in terms outcome psychotic conditions. Interest the field affective disorders and, particular, duration anxiety, has been recently registered as well. However, preliminary epidemiologic investigation phenomenon necessary. present study was aimed investigate and compare age at onset, DUI sample patients affected by different anxiety disorders. defined interval between onset...
Impulsivity represents a key dimension in obsessive-compulsive disorder (OCD), relation to outcome and course. It can be assessed through the Barratt Impulsiveness Scale (BIS), which explores three main areas: attentional, motor, nonplanning. Present study was aimed assess level of impulsivity sample OCD patients, comparison with healthy controls, using BIS.Seventy-five outpatients, 48 them having psychiatric comorbidities 70 were BIS, their scores analyzed Student's t-test for independent...
Obsessive-compulsive disorder (OCD) is a chronic illness associated with significant functional impairment. Monotherapy serotonin reuptake inhibitors (SRIs) often leads to only partial improvement of symptoms. In such cases, common, well established, treatment approach for most patients the augmentation SRI therapy antipsychotic medications. Brexpiprazole an atypical agent that acts as agonist 5-HT1A, D2, and D3 receptors. Purpose this retrospective observational study was evaluate...
While the efficacy of repetitive transcranial magnetic stimulation (rTMS) in Major Depressive Disorder (MDD) is well established, debate still open relation to bipolar depression and a possible different effectiveness high vs. low stimulation. The present study was aimed assess compare tolerability protocols augmentative rTMS sample patients with current Episode (MDE), poor drug response/treatment resistance diagnosis MDD or disorder.Thirty-three were recruited 4-week, blind-rater, trial...
Objective Obsessive-compulsive disorder (OCD) is associated with variable risk of suicide and prevalence attempt (SA). The present study aimed to assess the SA sociodemographic clinical features in a large international sample OCD patients. Methods A total 425 outpatients, recruited through International College Obsessive-Compulsive Spectrum Disorders (ICOCS) network, were assessed categorized groups or without history SA, their compared Pearson’s chi-squared t tests. Logistic regression was...
Obsessive-Compulsive Disorder (OCD) and Tic (TD) are highly disabling often comorbid conditions. Of note, the DSM-5 acknowledged a new 'tic-related' specifier for OCD, which might be referred to as (OCTD), raising interest toward better clinical characterisation of affected patients. Available literature indicates that early onset, male gender, sensory phenomena obsessions symmetry, aggressiveness, hoarding, exactness sounds well comorbidity with Attention Deficit Hyperactivity (ADHD) may...
Abstract Background Obsessive–compulsive disorder (OCD) is a prevalent and severe clinical condition. Robust evidence suggests gene-environment interplay in its etiopathogenesis, yet the underlying molecular clues remain only partially understood. In order to further deepen our understanding of OCD, it essential ascertain how genes interact with environmental risk factors, cross-talk that thought be mediated by epigenetic mechanisms. The human microbiota may key player, because bacterial...
Obsessive-compulsive disorder (OCD) is characterized by a range of phenotypic expressions. Gender may be relevant factor in mediating the disorder's heterogeneity. The aim present report was to explore large multisite clinical sample OCD patients, hypothesizing existing demographic, geographical and differences between male female patients with OCD.Socio-demographic variables 491 adult outpatients recruited International College Obsessive-Compulsive Spectrum Disorders (ICOCS) network were...
Bipolar disorder (BD) and obsessive-compulsive (OCD) comorbidity is an emerging condition in psychiatry, with relevant nosological, clinical, therapeutic implications.
Abstract Obsessive Compulsive Disorder (OCD) is listed as one of the top 10 most disabling neuropsychiatric conditions in world. The neurobiology OCD has not been completely understood and efforts are needed order to develop new treatments. Beside classical neurotransmitter systems signalling pathways implicated OCD, possible involvement endocannabinoid system (ECS) emerged pathophysiology OCD. We report here selective downregulation genes coding for enzymes allowing synthesis...