A5052846383- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Health and Medical Research Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Healthcare cost, quality, practices
- Artificial Intelligence in Healthcare and Education
- Airway Management and Intubation Techniques
- Veterinary Pharmacology and Anesthesia
- Inhalation and Respiratory Drug Delivery
- Hemodynamic Monitoring and Therapy
- Angiogenesis and VEGF in Cancer
- Diagnosis and Treatment of Venous Diseases
- Abdominal Surgery and Complications
- Non-Invasive Vital Sign Monitoring
- Anesthesia and Sedative Agents
- Peripheral Artery Disease Management
- Innovations in Medical Education
- Anesthesia and Neurotoxicity Research
- Potassium and Related Disorders
- Cardiomyopathy and Myosin Studies
- Medical and Biological Ozone Research
- scientometrics and bibliometrics research
University of Geneva
2018-2024
University Hospital of Geneva
2020-2024
University of Lisbon
2017-2024
University of Lausanne
2023
University Hospital of Lausanne
2023
Abstract Background Prolonged intensive care unit (ICU) stay is associated with physical, cognitive, and psychological disabilities. The impact of baseline frailty on long-stay ICU patients remains uncertain. This study aims to investigate how influences mortality post-ICU disability 6 months after critical illness in patients. Methods In this retrospective cohort study, we assessed hospitalized for ≥ 7 days the between May 2018 2021, following them up or until death. Based Clinical Frailty...
Hypophosphatemia is frequently observed in the ICU and associated with several impairments such as respiratory failure or infections. We hypothesized that hypophosphatemia on admission a prolonged duration of mechanical ventilation length stay (LOS), particularly COVID-19 patients. This cross-sectional study analyzed data from 1226 patients hospitalized Geneva University Hospitals August 2020 to April 2021. Patients were categorized having (phosphatemia ≤ 0.8 mmol/L) non-hypophosphatemia >...
We have previously shown that low-dose ionizing radiation (LDIR) induces angiogenesis but there is no evidence it neovascularization in the setting of peripheral arterial disease. Here, we investigated use LDIR as an innovative and non-invasive strategy to stimulate therapeutic using a model experimentally induced hindlimb ischemia (HLI).After surgical induction unilateral HLI, both hindlimbs female C57BL/6 mice were sham-irradiated or irradiated with four daily fractions 0.3 Gy, consecutive...
Changes in lung mechanics are frequently inferred from intact-chest measures of total respiratory system without consideration the chest wall contribution. The participation lungs and has not been evaluated systematically small animals commonly used research. Thus, we compared these contributions mice, rats, rabbits further characterized influence positive end-expiratory pressure (PEEP). Forced oscillation technique was applied to anesthetized mechanically ventilated healthy obtain impedance...
Severe COVID-19-related acute respiratory distress syndrome (C-ARDS) requires mechanical ventilation. While this intervention is often performed in the prone position to improve oxygenation, underlying mechanisms responsible for improvement function during invasive ventilation and awake positioning C-ARDS have not yet been elucidated. In prospective observational trial, we evaluated of patients while supine positions (n = 13) or non-invasive 15). The primary endpoint was positional change...
Whereas time capnography (Tcap) is routinely displayed during mechanical ventilation, the volumetric representation (Vcap) seldom used. We compared diagnostic value of indices derived from Tcap and Vcap following ventilation to perfusion ratio (V ̇⁄Q ̇ ) mismatch subsequent experimentally induced acute respiratory distress syndrome (ARDS), alveolar recruitment by elevating positive end-expiratory pressure (PEEP). Lung injury was iv lipopolysaccharide, whole lung lavage injurious in...
BACKGROUND MD-PhD programmes throughout the world provide a platform for medical trainees to commit physician-scientist career, qualifying with both degree (MD or equivalent) and Doctor of Philosophy (PhD). However, there are limited studies assessing characteristics in Europe outcomes students graduates. PURPOSE This study aims at first country-wise exploration characteristics, opinions, academic graduates Europe. METHODS Two questionnaires were developed assess demographics, programme...
Abstract Background Benefits of variable mechanical ventilation based on the physiological breathing pattern have been observed both in healthy and injured lungs. These benefits not characterized pediatric models effect this mode regional distribution lung inflammation also remains controversial. Here, we compare structural, molecular functional outcomes reflecting between PVV conventional pressure-controlled (PCV) a model lungs acute respiratory distress syndrome (ARDS). Methods New-Zealand...
Critical limb ischemia (CLI) is a serious condition that entails high risk of lower amputation. Despite revascularization being the gold-standard therapy, considerable number CLI patients are not suited for either surgical or endovascular revascularization. Angiogenic therapies emerging as an option these but currently still under investigation. Before application in humans, those must be tested animal models and its mechanisms clearly understood. An model hindlimb (HLI) has been developed...
Capnoperitoneum during laparoscopy leads to cranial shift of the diaphragm, loss in lung volume, and risk impaired gas exchange. Infants are susceptible these changes bedside assessment volume might assist with optimizing ventilation. Thus, primary aim was investigate monitoring value a continuous end-expiratory (EELV) method based on CO2 dynamics ( EELVCO2 ) pediatric capnoperitoneum model by evaluating correlation trending ability against helium washout (EELVHe ).Intra-abdominal pressure...
Although high-frequency percussive ventilation (HFPV) improves gas exchange, concerns remain about tissue overdistension caused by the oscillations and consequent lung damage. We compared a modified modality created superimposing to conventional waveform during expiration only (eHFPV) with mechanical (CMV) standard HFPV. Hypoxia hypercapnia were induced decreasing frequency of CMV in New Zealand White rabbits (n = 10). Following steady-state periods, modalities randomly introduced entire...
Abstract Background MD-PhD programs confer degrees that empower medical doctors with in-depth scientific skills to contribute biomedical research and academic medicine, alongside clinical practice. Whilst the career options opportunities related graduates following these in US are well documented, little is known about their European counterparts. In this article, we studied who had completed program at University of Geneva between 2010 2019. Methods A cross-sectional survey was performed...
Positive pressure ventilation exerts an increased stress and strain in the presence of pulmonary fibrosis. Thus, strategies that avoid high pressures while maintaining lung aeration are paramount importance. Although physiologically variable (PVV) has proven beneficial various models disease, its potential advantages fibrosis have not been investigated. Therefore, we assessed benefit PVV over conventional pressure-controlled (PCV) a model Lung was induced with intratracheal bleomycin...
The advantages of physiologically variable ventilation (PVV) based on a spontaneous breathing pattern have been demonstrated in several respiratory conditions. However, its potential benefits chronic obstructive pulmonary disease (COPD) not yet characterized. We used an experimental model COPD to compare function outcomes after 6 h PVV versus conventional pressure-controlled (PCV). Rabbits received nebulized elastase and lipopolysaccharide throughout 4 weeks. After 30 days, animals were...
Resistance to the effects of rocuronium and other neuromuscular blocking agents (NMBA) has been previously reported, including delayed onset relaxation, rapid recovery incomplete paralysis under recommended doses. These conditions have associated with denervation injury, burns, immobilisation, infections, metabolic disorders, drug interactions. In this report, we describe case a young male without any known pre-disposing factor for NMBA resistance, who failed attain muscle relaxation...
Background Capnoperitoneum provides a ventilatory challenge due to reduction in end‐expiratory lung volume and peritoneal carbon dioxide absorption both children adults. The primary aim of this controlled interventional trial was determine the positive pressure (PEEP) level needed ensure for adequate clearance preservation homeostasis an experimental model infant laparoscopy. secondary evaluate potential effects on cardiac output PEEP abdominal variations same setting. Methods Eight...
Critical limb ischemia (CLI) is a serious condition that entails high risk of lower amputation. Despite revascularization being the gold-standard therapy, considerable number CLI patients are not suited for either surgical or endovascular revascularization. Angiogenic therapies emerging as an option these but currently still under investigation. Before application in humans, those must be tested animal models and its mechanisms clearly understood. An model hindlimb (HLI) has been developed...
Abstract Background : MD-PhD programs confer degrees that empower medical doctors with in-depth scientific skills to contribute biomedical research and academic medicine, alongside clinical practice. Whilst the career options opportunities related graduates following these in US are well documented, little is known about their European counterparts. In this article, we studied who had completed program at University of Geneva between 2010 2019. Methods: A cross-sectional survey was performed...
Background: Although spontaneous breathing is known to exhibit substantial physiological fluctuation that contributes alveolar recruitment, changes in the variability of respiratory pattern following inhalation carbon dioxide (CO 2 ) and volatile anesthetics have not been characterized. Therefore, we aimed at comparing indices under wakefulness, sleep, hypercapnia sedative anesthetic concentrations sevoflurane. Methods: Spontaneous was recorded on two consecutive days six rabbits using open...