A5082553192- Advanced Sensor and Energy Harvesting Materials
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Tactile and Sensory Interactions
- Stroke Rehabilitation and Recovery
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Circadian rhythm and melatonin
- Silk-based biomaterials and applications
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Cerebral Palsy and Movement Disorders
- Molecular Communication and Nanonetworks
- Knee injuries and reconstruction techniques
- Balance, Gait, and Falls Prevention
- Neural dynamics and brain function
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Vagus Nerve Stimulation Research
- Advanced Materials and Mechanics
- Gaze Tracking and Assistive Technology
- Conducting polymers and applications
École Polytechnique Fédérale de Lausanne
2017-2024
Wyss Center for Bio and Neuroengineering
2020-2023
University of Geneva
2023
Abstract The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel precise communication with biological tissue, particularly the nervous system. However, translation lab‐based innovation toward clinical use calls for further advances in materials, manufacturing characterization paradigms, design rules. Herein, a translational framework engineered to accelerate deployment microfabricated interfaces research is proposed applied soft...
Abstract Background Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications may arise, namely cuff displacement nerve compression, due to a poor adaptability variable shapes and sizes encountered vivo. Improvements design, materials, closing mechanism surgical approach are necessary overcome these issues....
Abstract Next‐generation bioelectronic implants require miniaturization, durability, and long‐term functionality. Thin film encapsulations, prepared with inorganic or hybrid organic/inorganic designs, are essential for ensuring protection, low water permeation, adaptability, structural strength. It is equally important to precisely measure their barrier performance, especially in vivo use, ensure the manufacture of reliable bioelectronics. Current monitoring solutions not adequate: they...
Reaching and grasping impairments significantly affect the quality of life for people who have experienced a stroke or spinal cord injury. The long-term well-being patients varies greatly according to restorable residual capabilities. Electrical stimulation could be promising solution restore motor functions in these conditions, but its use is not clinically widespread. Here, we introduce HandNMES, an electrode array (EA) neuromuscular electrical (NMES) aimed at grasp training assistance....
Traditional microelectrode arrays (MEAs) are limited to measuring electrophysiological activity in two dimensions, failing capture the complexity of three-dimensional (3D) tissues such as neural organoids and spheroids. Here, we introduce a flower-shaped MEA (e-Flower) that can envelop submillimeter brain spheroids following actuation by sole addition cell culture medium. Inspired soft microgrippers, its mechanism leverages swelling properties polyacrylic acid hydrogel grafted polyimide...
Wearable electronic circuits based on the films of gallium and its alloys offer promising implementations in health monitoring gaming sensing applications. However, complex rheology liquid metals makes it challenging to manufacture thin gallium‐based devices with reliable, reproducible, stable properties over time. Herein, surface coating topography silicone substrates are engineered enable precisely defined, micrometer‐thick metal patterns large (>10 cm 2 ) areas, high design...
Background: Chondrocyte-based cell therapy to repair cartilage has been used for >25 years despite current limitations. This work presents a new treatment option lesions. Hypothesis: High-quality hyaline microtissues called Cartibeads are capable of treating focal chondral lesions once implanted in the defect, by complete fusion among themselves and their integration with surrounding native subchondral bone. Study Design: Controlled laboratory study. Methods: were first produced from...
Abstract Integrated wearable electronics capable of transducing and transmitting biophysical information on complex dynamic systems are attracting high interest across the consumer electronics, clinical, research domains. Gallium gallium‐based liquid metals (LMs) emerge as promising conductor technology for wearables due to their excellent combination electrical conductivity mechanical compliance. However, LMs feature physical chemical properties that pose significant manufacturability...
Highly reproducible and stable liquid metal conductors for stretchable electronics applications are presented in article number 1900079, by Stéphanie P. Lacour co-workers. By manufacturing thin large-area films on 4 inch diameter silicone substrates, soft sensors with high accuracy developed to sense human motion.
Abstract Haptic perception of softness is a unique feature the human skin that relies on concurrent measurements lateral deformation and compression during object manipulation. This challenging to implement in robotics because combined requirements sensing modalities, format, robotic structures, synthetic materials. A soft sensory supporting distributed bimodal mechanical over large surface area suitable for hand manipulation reported. Resistive pressure strain sensors are prepared with...
In article 1906512, Stéphanie P. Lacour and co-workers propose an experimental framework to advance the translation of soft, implantable bioelectronic interfaces toward medical research use. A biomimetic in vitro multimodal platform captures dynamic biophysical environment replicates vivo function soft implant fast-forward its validation therapeutical
Enriched environments and tools are believed to promote grasp rehabilitation after stroke. We designed S2, an interactive system consisting of smart objects, custom orthoses for selective constraining, electrode array forearm NMES. Motor improvements perceived usability a new enriched upper limb training sub-acute stroke patients was assessed in this interim analysis. Inclusion criteria: with MMSE>20, ipsilesional MI>80%, contralesional MI<80%. Effects 30-min therapy supplements,...
In this paper, we report a fully stretchable liquid metal based sensor system for compliance detection. The is composed of strain layer, gap layer with hole in the center and pressure from top to bottom. Inspired human tactile system, work collaboratively detect force deformation simultaneously, which contact material can be derived.
This paper details the development and preliminary testing of GaitSkin, a wearable haptic interface designed for generating sensorimotor conflicts during locomotion. The system leverages real-time gait tracking wireless vibrotactile skin patch to produce between motor actions tactile feedback with potential applications in neuroscience research particularly induce hallucinations on Parkinson's disease patients. Initial healthy subjects demonstrates comfort, effectiveness, this accurately...