A5065889541- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Amino Acid Enzymes and Metabolism
- Nuclear Structure and Function
- Telomeres, Telomerase, and Senescence
- Hippo pathway signaling and YAP/TAZ
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Pluripotent Stem Cells Research
- RNA regulation and disease
- RNA modifications and cancer
- vaccines and immunoinformatics approaches
- Protein Kinase Regulation and GTPase Signaling
- Organ Transplantation Techniques and Outcomes
- Digital Mental Health Interventions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- BRCA gene mutations in cancer
University of Naples Federico II
1996-2023
Institute for Experimental Endocrinology and Oncology
2023
University of Reggio Calabria
1996
The Thyroid Hormone (TH) activating enzyme, type 2 Deiodinase (D2), is functionally required to elevate the TH concentration during cancer progression advanced stages. However, mechanisms regulating D2 expression in still remain poorly understood. Here, we show that cell stress sensor and tumor suppressor p53 silences expression, thereby lowering intracellular THs availability. Conversely, even partial loss of elevates D2/TH resulting stimulation increased fitness cells by boosting a...
We analyzed the expression and relative distribution of mRNA for regulatory subunits (RIalpha, RIIalpha, RIIbeta) 150-kDa RIIbeta-anchor proteins cyclic AMP (cAMP)-dependent protein kinase (PKA) into discrete brain regions. The subcellular both holoenzyme free catalytic subunit was evaluated in same CNS areas. In neocortex corpus striatum high levels RIIbeta paralleled presence specific RII-anchoring proteins, membrane-bound PKA holoenzyme, low cytosolic activity (C-PKA). Conversely, areas...