A5045198690- Phytochemicals and Antioxidant Activities
- Biochemical Analysis and Sensing Techniques
- Probiotics and Fermented Foods
- Natural product bioactivities and synthesis
- Food composition and properties
- Microencapsulation and Drying Processes
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Fermentation and Sensory Analysis
- Tea Polyphenols and Effects
- Proteins in Food Systems
- Traditional Chinese Medicine Analysis
- Biochemical and biochemical processes
- Diet and metabolism studies
- Microbial Metabolites in Food Biotechnology
- Supramolecular Self-Assembly in Materials
- Antimicrobial agents and applications
- Polysaccharides and Plant Cell Walls
- Berberine and alkaloids research
- Horticultural and Viticultural Research
- Polysaccharides Composition and Applications
- Protein Hydrolysis and Bioactive Peptides
- Advanced Drug Delivery Systems
- Gut microbiota and health
- Bacterial biofilms and quorum sensing
Shenzhen University
2021-2024
Innovation Team (China)
2024
Dongguan University of Technology
2024
Wenzhou Medical University
2023
Shenyang Pharmaceutical University
2013-2020
Thus far, little is known about whether jackfruit flake, a byproduct of jackfruit, can be used as fermentation substrate to obtain value-added products through microbial fermentation. Here, flake puree was fermented by three different ways: spontaneous (JF), inoculated with LAB (JFL), co-fermentation and yeast (JFC). In contrast JF, the total polyphenol flavonoid content syndrome-associated enzyme inhibition are significantly increased in JFC at end Electronic tongue analysis revealed that...
In this study, a new fermented food was developed using pineapple by-products and whey protein (2.6%) as raw materials through the co-fermentation of autochthonous lactic acid bacteria yeast. To better understand fermentation mechanism impact microorganisms on entire system, we tracked changes in carbohydrate amino profiles, organoleptic quality microbial community during process. Compared with unfermented samples, dietary fiber free acids increased significantly proceeded. The samples were...
Astragaloside IV (ASIV) is a typical bioactive constituent of Radix Astragali. The study aimed to investigate the enterohepatic circulation ASIV and evaluate impact activity intestinal microbiota on deposition ASIV. amounts its metabolites were quantified by an LC-MS/MS method. was metabolized bacteria form brachyoside B (Bra B), cyclogaleginoside (Cyc cycloastragenol (CA), iso-cycloastragenol (iso-CA), dehydrogenated metabolite CA (CA-2H). iso-CA circulated in blood besides when rats...
Moderate red wine consumption has been linked to reduced chronic disease risk. Thus far, little known about the physicochemical properties and potential biological effects of high-molecular-weight polyphenolic complexes (HPPCs), a major fraction polyphenols. In this work, stability biochemical HPPCs under simulated gastrointestinal conditions in vitro were studied. The results showed that resistant gastric digestion (SGD) intestinal (SID). They exhibited significant inhibitory activity...
Abstract Many important food bioactive compounds are plant secondary metabolites that have traditional applications for health promotion and disease prevention. However, the chemical instability poor bioavailability of these represent major challenges to researchers. In last decade, therefore, impetus has been given research development advanced carrier systems delivery natural molecules. Among them, stimuli‐responsive carriers hold great promise simultaneously improving stability,...
Red wine polyphenolic complexes have attracted increasing attention as potential modulators of human metabolic disease risk. Our previous study discovered that red high-molecular-weight polymeric (HPPCs) could inhibit key syndrome-associated enzymes and favorably modulate gut microbiota (GM) in simulated colonic fermentation assay vitro. In this work, the efficacy HPPC supplementation (150 300 mg/kg/day, respectively) against high-fat diet (HFD)-induced disturbance mice was investigated....
Tiopronin, as a novel thiol-containing nucleophile, was introduced for depolymerizing polymeric proanthocyanidins from grape seed into catechins and three new proanthocyanidin–tiopronin degradation products: (+)-catechin-4β-S-tiopronin methyl ester (CT), (−)-epicatechin-4β-S-tiopronin (ECT), (−)-epicatechin gallate-4β-S-tiopronin (ECGT). A Box–Behnken design employed to optimize conditions based on single-factor experiments obtain target products. Each of the compounds isolated by high-speed...
Abstract: The objective of this study was to develop a self-microemulsifying drug delivery system (SMEDDS) enhance the oral bioavailability poorly water-soluble compound 20(S)-25-methoxydammarane-3β;12β;20-triol (25-OCH 3 -PPD). Optimized SMEDDS formulations for 25-OCH -PPD contained Cremophor ® EL (50%) as surfactant, glycerin (20%) cosurfactant, and Labrafil M1944 (30%) oil. were characterized by morphological observation mean droplet size. pharmacokinetics 25-OCH3-PPD suspension evaluated...
1. The pharmacokinetics of the 25-OCH3-PPD epimers and active metabolites in rat plasma after a single intravenous (i.v.) administration were studied by rapid, selective sensitive UPLC-MS/MS method.2. Chromatographic separation was performed on an Acquity UPLC with Agela C18 column, solvents 5 mM ammonium acetate (pH 7.8) – acetonitrile (65: 35, v/v) used as mobile phase for elution. quantification transitions m/z 493.5 → 475.5 20(R,S)-25-OCH3-PPD, 479.5 461.5 20(R,S)-25-OH-PPD. Lower Limit...
Consumption of natto, a traditional eastern Asian food made fermented soybeans by <em>Bacillus Subtilis</em>, has long been linked to healthy aging and longer human lifespan. As the key thrombolytic ingredient serine protease nattokinase (NK) developed into widely-used dietary supplement. NK shown excellent anti-thrombus, thrombolytic, anti-inflammation activities that potentially delay provide therapeutic effects on aging-related diseases. In this review, we critically overview experimental...
Eye trauma, ophthalmic surgery and contact lens (CL) wearing cause corneal infection bacterial biofilms formation, which further lead to ulcer perforation. In view of the low bioavailability antibiotic eye drops clinical problems that resistance, we used pH sensitive zeolitic imidazolate framework-8 metal-organic frameworks (ZIF-8 MOFs) load broad-spectrum antibacterial drugs levofloxacin (LEVO). After surface modification by hyaluronic acid (HA), nanomaterial was negatively charged. A...