A5082583073- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Identification and Quantification in Food
- Molecular Biology Techniques and Applications
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Synthesis and biological activity
- Digestive system and related health
- Diet and metabolism studies
- COVID-19 epidemiological studies
- Circular RNAs in diseases
- Salmonella and Campylobacter epidemiology
- Gestational Diabetes Research and Management
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Cynara cardunculus studies
- Chemical Reactions and Mechanisms
- Adipose Tissue and Metabolism
- Biochemical Acid Research Studies
- Organic Chemistry Cycloaddition Reactions
- FOXO transcription factor regulation
- Paraoxonase enzyme and polymorphisms
- Genetic factors in colorectal cancer
Kermanshah University of Medical Sciences
2020-2025
University of Tehran
1970-1973
Razi Vaccine and Serum Research Institute
1970
Abstract Background and aims Preeclampsia (PE) is a serious medical condition that usually causes high blood pressure affects multiple organs. Considering the adverse effect of oxidative stress on process PE in pregnant women regarding role Nrf2 gene placental pathways, this study was conducted to investigate DNA methylation status healthy women. Materials methods The present case-control consisted 70 Blood placenta samples were taken from all subjects, percentage assessed by Methyl Light...
<title>Abstract</title> <bold>Background: </bold>Colorectal cancer (CRC) pathogenesis is influenced by genes promoter region methylation, a key epigenetic mechanism. We sought to determine whether <italic>FOXF1</italic>promoter methylation in stool samples could serve as CRC biomarker. <bold>Materials and methods:</bold> analyzed <italic>FOXF1</italic> gene from 50 patients healthy controls. The percentage of reference (PMR) value was determined for each sample. <bold>Results:</bold> PMR...
Purpose: The study aimed to investigate the effect of breastfeeding, formula feeding and mix (breastfed plus formula-fed) on expression level obesity-predisposing genes including fat mass obesity-associated ( FTO ), carnitine palmitoyltransferase 1A CPT1A peroxisome proliferator-activated receptor-α PPAR-α ) in 5- 6-month-old infants. Patients Methods: A total 150 infants participated this case–control study. All subjects were healthy aged 5– 6 months that divided into 3 groups: breastfed,...
Abstract Background Colorectal cancer (CRC) is a common malignancy worldwide. MicroRNAs (miRNAs) are important epigenetic alterations that notably impact various physiological and pathological processes by acting as negative regulators of gene expression. Furthermore, they have vital function in different types cancers, including CRC. In this research, we evaluated, for the very first time, expression levels miR-196a-1 tissue plasma patients with CRC also homeobox D8 ( HOXD8 ) target gene....
The beneficial effects of theobromine (TB) on obesity and features metabolic syndrome (MetS) have been reported in several studies.
Background: The objective was to elucidate the potential epigenetic regulatory mechanism in HMOX1 expression preeclampsia. Materials & methods: promoter DNA methylation evaluated placental tissue and blood of preeclamptic normotensive pregnant women. miR-153-3p gene were assessed peripheral mononuclear cells (PBMCs). Related microarray datasets Gene Expression Omnibus database also analyzed. Results: In tissue, despite downregulation, there no significant change methylation. PBMCs,...
Epigenetic modifications such as DNA methylation in the CpG islands of genes occur at a high rate. In this study, we measured level promoter region FOXF1 gene new blood biomarker for detection colorectal cancer early stages.The was plasma samples 50 patients and normal individuals. extracted after exposure to sodium bisulfite by MethyLight polymerase chain reaction (PCR) method. The percentage all samples, statistical analysis done using SPSS v24 software.The average between healthy...
Aim: The miR-138-5p promoter-methylated DNA level, and PDL1 expression were investigated in colorectal cancer (CRC) patients. Materials & methods: promoter methylation status using the MethyLight qPCR method, respectively. For measuring PDL-1, we applied Bioassay Technology Elisa kit. Results: percentage of methylated reference values plasma tissue samples from patients was higher than control groups. area under curve presented a sensitivity 55% specificity 82.5% for samples. Compared with...
Colorectal cancer (CRC) is one of the most common cancers worldwide. The beginning and progression disease are thought to be determined by combinations epigenetic genetic changes that trigger multistep programs carcinogenesis. In colorectal cancer, alterations, in particular promoter CpG island methylation, occur more commonly than mutations. Hyper-methylation contributes carcinogenesis via inducing transcriptional silencing or down-regulation tumor suppressor genes. DNA methylation...
Abstract Background and aims Preeclampsia (PE) is a serious medical condition that usually causes high blood pressure affects multiple organs. Considering the adverse effect of oxidative stress on process PE in pregnant women regarding role Nrf2 gene placental pathways, this study was conducted to investigate DNA methylation status healthy women. Materials methods The present case-control consisted 70 Blood placenta samples were taken from all subjects, percentage assessed by Methyl Light...
Background: The aim of this study was to estimate the seroprevalence SARS-CoV-2 infection in a general population from Kermanshah province, Iran. Methods: present population-based cross-sectional design conducted province 2020. Sampling performed multi-stage process, and 1967 participants were considered, also 174 interviewers assigned collect data online. Then, 5 mL blood sample taken every participant. samples centrifuged with ELISA method detect SARS-CoV-2-specific IgG IgM antibodies...
Background: The aim of this study was to estimate the seroprevalence SARS-CoV-2 infection in a general population from Kermanshah province, Iran. Methods: present population-based cross-sectional design conducted province 2020. Sampling performed multi-stage process, and 1967 participants were considered, also 174 interviewers assigned collect data online. Then, 5 mL blood sample taken every participant. samples centrifuged with ELISA method detect SARS-CoV-2-specific IgG IgM antibodies...
Abstract Mislabeling of hamburgers with undeclared chicken has frequently been reported. A fast TaqMan real-time PCR assay was developed to estimate percentage in raw and heat-treated the current work. The calibration curve plotted normalization approach (ΔCt; difference calculation between chicken-cytb eukaryotic-18S rRNA assays) for five reference mixtures (100-0.01%) using a duplex TaqMan-qPCR protocol. R 2 efficiency values normalized were 0.9993 ~100%, respectively. In validation plan,...
Background: Anemia is one of the most common diseases in women. According to some studies, vitamin D seems be involved hematopoietic process. Therefore, this study was performed investigate relationship between 25-hydroxyvitamin deficiency and anemia
زمینه و هدف: بیماری کبد چرب غیرالکلی رایجترین کبدی است که در حال پیشرفت بوده بیش از یکچهارم مردم جهان را درگیر خود ساخته است. این پژوهشگران معتقدند فعالیت ورزشی استفاده داروهای گیاهی با خواص ضدچربی ضداکسایشی میتواند بهعنوان درمان مکمل، سودمند باشد. بنابراین، هدف پژوهش تعیین آثار هشت هفته تمرین هوازی یا مصرف عرق آرتیشو بر سطوح چربی سرمی آنزیمهای زنان مبتلا به بود. مواد روشها: بدینمنظور، 24 زن داوطلب چاق دارای اضافه وزن میانگین سن 8/9±3/39 سال 1/12±4/75 کیلوگرم بهطور تصادفی سه گروه...