A5048309252- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- Cervical Cancer and HPV Research
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- COVID-19 and Mental Health
- Cytokine Signaling Pathways and Interactions
- Viral-associated cancers and disorders
- Influenza Virus Research Studies
- Mycobacterium research and diagnosis
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Vector-Borne Animal Diseases
- Pharmacological Effects of Natural Compounds
Golestan University of Medical Sciences
2016-2025
Golestan University
2016-2025
Tarbiat Modares University
2009-2017
Nuclear Science and Technology Research Institute
2014
Mycobacterium avium subspecies Paratuberculosis (MAP) is a bacterium known to cause Johne's disease in ruminants and has been implicated several autoimmune diseases. This study aimed investigate the potential association between MAP infection Rheumatoid Arthritis (RA). A total of 119 patients with RA 120 healthy controls (HCs) were enrolled study. The participants outpatient attendees at rheumatology specialist's clinic, selected according 2010 ACR/EULAR Classification Criteria for RA. Their...
Background: C1q/TNF-related proteins (CTRPs) are a new family of secretory adipokines that exhibit functional tasks in the metabolic/energy status body, obesity, and inflammation. Little research has been conducted on CTRPs malignancies. Objectives: For first time, this explored serum values CTRP9 CTRP12 colorectal cancer patients (CRCs), their relationship with clinicopathology. Methods: This study enrolled 44 CRCs healthy controls (HCs) aged 15 to 76 years. were measured, using ELISA...
Hepatitis B virus (HBV) infection is one of the clinical dilemmas in chronic liver diseases. MicroRNAs (miRNAs) are small noncoding RNA molecules that play an important role pathogenesis diseases and single nucleotide polymorphisms (SNPs) miRNA genes affect course HBV infection. Previous studies have shown miRNA‐146a rs2910164 polymorphism can be associated with such as hepatocellular carcinoma. The present study investigated association between susceptibility to Iranian population....
The pattern and distribution of human rotavirus genotypes in young children developing countries play an important role epidemiological studies, as well providing a strategy for the development future vaccine.We evaluated stool samples from 349 with acute gastroenteritis Northern Iran (Gorgan city, Golestan province). Polyacrylamide Gel Electrophoresis (PAGE) Latex Agglutination Test (LAT) were utilized to determine prevalence fecal samples. Moreover semi-multiplex RT-PCR technique was...
Novel coronavirus (severe acute respiratory syndrome-coronavirus-2: SARS-CoV-2), which arose from Wuhan, China, has rapidly spread to other countries and developed into a pandemic. Although the manifestations of SARS-CoV-2 are well-documented, there is considerable challenge regarding direct and/or indirect infection in organs. Several preliminary reports confirmed neurological SARS-CoV-2-infected patients. Here, we report detection nasopharyngeal swab cerebrospinal fluid (CSF) 34-month-old...
<i>Objective:</i> Human papillomavirus (HPV) oncoproteins (i.e. E6 and E7) are constitutively expressed in cervical cancer cells. The proteins ideal targets to be used for developing therapeutic vaccines against existing HPV-associated carcinomas. To date, whole bacteriophage (‘phage’)-λ particles, rather than purified ‘naked’ DNA, have been described as highly efficient delivery vehicles a DNA vaccine. <i>Methods:</i> In this study, safe λ-based vaccine, recombinant...
This study investigated the relationship between viral load and incidence of olfactory gustatory dysfunction (OD GD), respiratory gastrointestinal symptoms recovery OD GD in COVID-19 patients.
Hashimoto's thyroiditis (HT) is an autoimmune disorder of the thyroid gland that can cause hypothyroidism. As HT a multifactorial disorder, activation immune responses in genetically predisposed individuals exposed to some environmental factors contribute it. Microorganisms, as factors, including Mycobacterium avium ssp. paratuberculosis (MAP) by molecular mimicry, be important this disorder. This study aimed investigate association between MAP and HT. case-control included 110 participants...
Today, the human papillomavirus (HPV) L1 protein is main target in construction of prophylactic HPV vaccines. The production virus-like particles (VLPs) that closely resemble natural structure HPV16 virus and induce high levels virus-neutralizing antibodies animals humans facilitated by expression HPV16-L1 eukaryotic cells. Bac-to-Bac system has been previously used to produce recombinant proteins. In this study, we utilized generate VLPs
Influenza complications are mild to serious, and can cause death in some cases. A great deal of attention has been paid recent years the development use new antiviral compounds overcome drug resistance certain strains influenza virus treat clinical implications. This study aimed investigate effect punicalagin its associated mechanism against (H1N1)
Background:The p53 mutation is uncommon in EBV-linked gastric carcinoma, but its suppression occurs through mechanisms such as USP7 inhibition via EBNA1 activity.This study aimed to evaluate the effect of on p53inhibiting gene expression and impact suppression.Methods: MKN-45 cells were transfected with plasmid.A stable cell line was developed selection based hygromycin B resistance.MDM4, MDM2, SIRT3, HDAC1, PSMD10, USP7, checked using real-time PCR.Also, containing or control plasmid...
During the coronavirus disease 2019 (COVID-19) pandemic, simultaneous detection of severe acute respiratory syndrome 2 (SARS-CoV-2) and Influenza A, B viruses is essential for rapid differential diagnosis in patients with similar symptoms, especially during "flu season" post-pandemic era. So far, several multiplex methods have been approved SARS-CoV-2, B. However, due to mutation rate SARS-CoV-2 genome emergence new variants, existing must be improved updated.To identify a highly conserved...
Vesicular stomatitis virus (VSV) is under development as an oncolytic due to its preferential replication in cancer cells and activity, however the viral components responsible have not yet been determined. In this study effects of VSV wild-type (wt) M51R-mutant matrix proteins (M51R-mMP) on apoptosis, pyroptosis, necroptosis, autophagy pathways, esophagus cell line (KYSE-30) were investigated.The KYSE-30 transfected with pcDNA3.1 plasmids encoding wt or M51R-mMP, evaluated 48 72 hours after...
SARS-CoV-2 put a heavy financial burden on the healthcare system, with millions of laboratory-confirmed cases and deaths worldwide in last 2 years. During seventh wave this pandemic, continuously evolving nature resulted emergence new variants that harbor different mutations. Mutations are associated changes virus behavior, including increased transmissibility, virulence, evasion neutralizing antibodies. Currently, we need detailed comprehensive genomic information all variants. One key...
Hepatitis B virus (HBV) X protein (HBx) plays a key role in hepatocellular carcinoma (HCC). HBx may alter the expression of multiple microRNAs (miRs), which are important hepatocarcinogenesis. This study aimed to investigate importance miR-21, miR-22, miR-122, miR-132, and miR-222. A recombinant vector expressing was developed. The Huh-7 cell line transfected with HBx-pcDNA3.1+ plasmid. Real-Time Polymerase Chain Reaction used evaluate miR-222 line. It found that miR-21 upregulated at all...
Beclin1 is an important, primary molecule for autophagy.It suggested that the control of autophagy path increases sensitivity tumor cells to VSV.In this study, degree gene expression in two cell lines, HeLa and A549, has been examined percentage living subsequent infection with virus evaluated by MTT assay method.The results showed comparison A549 reduced, these vesicular stomatits (VSV) oncolysis more than A549.It seems using some methods reducing autophagy, it possible make sensitive...