A5045289409- ZnO doping and properties
- Gas Sensing Nanomaterials and Sensors
- Nanowire Synthesis and Applications
- Copper-based nanomaterials and applications
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Semiconductor materials and devices
- MXene and MAX Phase Materials
- Nanopore and Nanochannel Transport Studies
- RNA Interference and Gene Delivery
- Electronic and Structural Properties of Oxides
- Biosensors and Analytical Detection
- 2D Materials and Applications
- Advanced Sensor and Energy Harvesting Materials
- nanoparticles nucleation surface interactions
- Mosquito-borne diseases and control
- Transition Metal Oxide Nanomaterials
- MicroRNA in disease regulation
- Microfluidic and Bio-sensing Technologies
- Advanced Memory and Neural Computing
- Quantum Dots Synthesis And Properties
- Analytical Chemistry and Sensors
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Magnesium Oxide Properties and Applications
Tokyo Institute of Technology
2024-2025
Nagoya University
2019-2024
Graduate School USA
2020
Kyushu University
2016-2019
Henan University of Science and Technology
2010
We demonstrate the facile, rational synthesis of monodispersedly sized zinc oxide (ZnO) nanowires from randomly seeds by hydrothermal growth. Uniformly shaped nanowire tips constructed in ammonia-dominated alkaline conditions serve as a foundation for subsequent formation monodisperse nanowires. By precisely controlling sharp tip and nucleation, our method substantially narrows distribution ZnO diameters σ = 13.5 nm down to 1.3 controls their diameter completely bottom-up method, even...
Biodetection for non-invasive diagnostics of fluids, especially urine, remains a challenge to scientists due low target concentrations. And biological complexes the detection may contain contaminants that also interfere with any assay. Dengue non-structural 1 protein (Dengue NS1) is an important biomarker dengue hemorrhagic fever and shock syndrome. Here, we developed Au-decorated nanowire platform applied it sandwich fluorophore-linked immunosorbent well plate assay (FLISA) detect NS1 in...
Zinc oxide (ZnO) nanowires have shown their potential in isolation of cancer-related biomolecules such as extracellular vesicles (EVs), RNAs, and DNAs for early diagnosis therapeutic development diseases. Since the function inorganic changes depending on morphology, previous studies established strategies to control morphology demonstrated attainment improved properties gas organic compound detection, dye-sensitized solar cells photoelectric conversion performance. Nevertheless,...
Chemiresistive gas sensors generally surfer from low selectivity, inferior anti-humidity, response signal or signal-to-noise ratio, severely limiting the precise detection of chemical agents. Herein, we exploit high-performance based on topological insulator Bi2Se3 that is distinguished conventional materials by robust metallic surface states protected time-reversal symmetry. In presence Se vacancies, nanosheets exhibit excellent sensing capability toward NO2, with a high 93% for 50 ppm and...
This study presents a ZnO nanowire-based microfluidic device that collects methylated DNA by selectively capturing unmethylated DNA, providing simple and efficient method for early cancer detection clinical diagnostics.
Relative humidity (RH) is an important physical quantity in industry, agriculture, and medical treatment. However, it still challenging to exploit high-performance sensors that can meet the detection requirement for responding both high variation low variation. In this work, ternary graphitic carbon nitride (g-C3N4) nanosheet/TiO2 nanoparticle/Ti3C2Tx nanosheet composites were synthesized by situ oxidation thermal polymerization. The response of g-C3N4/TiO2/Ti3C2Tx sensor reaches 531 from...
Cell-free DNA (cfDNA) and extracellular vesicles (EVs) are molecular biomarkers in liquid biopsies that can be applied for cancer detection, which known to carry information on the necessary conditions oncogenesis cell-specific activities after oncogenesis, respectively. Analyses both cfDNA EVs from same body fluid provide insights into screening identifying subtypes of cancer; however, a major bottleneck is lack efficient standardized techniques isolation clinical specimens. Here, we...
Researchers have demonstrated great promise for inorganic nanowire use in analyzing cells or intracellular components. Although a stealth effect of nanowires toward cell surfaces allows preservation the living intact when cells, as completely opposite approach, applicability to analyze components through disrupting is also central understanding cellular information. However, reported lysis strategy insufficient microbial due robustness and wrong approach taken so far (i.e., penetration into...
Ammonia is a well-known additive to promote crystal growth in hydrothermal synthesis of ZnO nanowires. Although the effect ammonia on nanowire has been intensively investigated, its influence seed layer, which governs initial growth, rarely discussed. Here, we demonstrate that strongly affects layer as well following growth. On increasing concentration, density first increases and then decreases, while rate keeps increasing. Experimental results thermodynamic calculations process reveal...
Extracellular vesicles (EVs) contain a subset of proteins, lipids, and nucleic acids that maintain the characteristics parent cell. Immunotherapy using EVs has become focus research due to their unique features bioinspired applications in cancer treatment. Unlike conventional immunotherapy tumor fragments, can be easily obtained from bodily fluids without invasive actions. We previously fabricated nanowire devices were specialized for EV collection, but they not suitable cell culturing. In...
Single crystalline nanowires composed of semiconducting metal oxides formed via a vapor-liquid-solid (VLS) process exhibit an electrical conductivity even without intentional carrier doping, although these stoichiometric are ideally insulators. Suppressing this unintentional doping effect has been challenging issue not only for oxide but also various nanostructured toward their semiconductor applications. Here we demonstrate that pure VLS crystal growth, which occurs at liquid-solid (LS)...
Field-effect transistors (FETs) are attractive biosensor platforms for rapid and accurate detection of various analytes through surface immobilization specific bio-receptors. Since it is difficult to maintain the electrical stability semiconductors sensing channel under physiological conditions long periods, passivation by a stable metal oxide dielectric layer, such as Al2O3 or HfO2, currently used common method prevent damage. However, protecting has disadvantage that distance between...
Since DNA analysis is the fundamental process for most applications in biomedical fields, capturing DNAs with high efficiency important. Here, we used several oxide nanowire microfluidic devices to capture CpG-rich single-stranded (ssDNAs) different pH solutions. All nanowires exhibited highest around 7 good shown by each metal oxide; ZnO/ZnO core/shell NWs (71.6%), ZnO/Al2O3 (86.3%) and ZnO/SiO2 (86.7%). showed best performance ssDNAs under varying pH, which suggests its suitability...
A sparse ZnO nanowire array with aspect ratio of ca. 120 and growth rate 1 μm/h was synthesized by controlling the density seeds at initial stage growth. The spatially-separated nanowires were cut off from substrate without breaking, thus useful in construction a single-nanowire device photolithography. exhibited linear current-voltage characteristic associated ohmic contact between electrodes. further demonstrated reliable photoresponse an IUV/Idark ∼100 to ultraviolet light irradiation.
Here we show a rational strategy to fabricate single crystalline NiO nanowires via vapor–liquid–solid (VLS) route, which essentially allows us tailor the diameter and spatial position. Our is based on suppression of nucleation at vapor–solid (VS) interface, promotes only liquid–solid (LS) interface. Manipulating both supplied material fluxes (oxygen metal) growth temperature enables enhancement LS Furthermore, this reduce down 550 °C, lowest so far reported.
Atomic layer deposition (ALD) is capable of providing an ultrathin on high-aspect ratio structures with good conformality and tunable film properties. In this research, we modified the surface ZnO nanowires through ALD for fabrication a ZnO/SiO2 (core/shell) nanowire microfluidic device which utilized capture CpG-rich single-stranded DNAs (ssDNA). Structural changes while varying number cycles were evaluated by statistical analysis their relationship efficiency was investigated. We...
A low-temperature Al2O3 deposition process provides a simplified method to form conductive two-dimensional electron gas (2DEG) at the metal oxide/Al2O3 heterointerface. However, impact of key factors interface defects and cation interdiffusion on is still not well understood. Furthermore, there blank space in terms applications that go beyond understanding interface's electrical conductivity. In this work, we carried out systematic experimental study by oxygen plasma pretreatment thermal...