A5020266807- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic factors in colorectal cancer
- Tryptophan and brain disorders
- Nutritional Studies and Diet
- Gut microbiota and health
- Nutrition and Health in Aging
- Diet and metabolism studies
- Genomics, phytochemicals, and oxidative stress
- Kruppel-like factors research
- Statistical Methods in Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Carcinogens and Genotoxicity Assessment
- Cell death mechanisms and regulation
- Folate and B Vitamins Research
- Hematological disorders and diagnostics
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Immune Response and Inflammation
- Clusterin in disease pathology
- Gout, Hyperuricemia, Uric Acid
- Nitric Oxide and Endothelin Effects
- Bacterial Identification and Susceptibility Testing
Universidad de Guadalajara
2013-2025
Mexican Social Security Institute
2013-2016
Laboratory of Molecular Genetics
2013
Type 2 diabetes is a significant health concern in the 21st century, and its prevalence continues to rise despite efforts promote preventive lifestyle changes. This increase has led higher economic burdens, prompting search for non-pharmacological methods manage glucose levels. To assess effects of flaxseed consumption on biochemical markers (glucose, glycated hemoglobin, total cholesterol, triglycerides) adult patients with Oaxaca, Mexico. Participants were recruited randomized into...
Human adenovirus 36 (HAdV-36) is associated with obesity, potentially by promoting adipocyte proliferation and differentiation. Although linked to increased fat storage, HAdV-36 also correlated improved insulin sensitivity. Given its potential role in modulating adipose tissue a less inflammatory metabolic profile, impacts on pro- anti-inflammatory cytokine secretion remain unclear. Methods: This nested case-control study compared levels (IL-10, IL-2, IL-6, IL-8, TNF-α) between patients...
Intron 4 VNTR (4a
The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function.Polymorphisms of TNF-α have been associated with cancer.We examined the -308G>A polymorphism this by comparing genotypes 294 healthy Mexican women those 465 breast cancer.The observed genotype frequencies for controls cancer patients were 1 14% AA, 13 21% GA, 86 65% GG, respectively.We found that...
The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved processing of amino acids.The analysis polymorphisms MTHFR has revealed associations with cancer; particular C677T ©FUNPEC-RP www.funpecrp.com.brGenetics and Molecular Research 14 (2): 4015-4026 (2015) polymorphism, which been suggested to affect folate metabolism, DNA methylation, synthesis, repair, contribute tumor promotion mammary gland.We examined polymorphism by comparing genotypes 339...
The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on null GSTM1 genotype has revealed associations with cancer, and been suggested to affect carcinogen metabolism contribute tumor promotion mammary gland. We examined by comparing genotypes 276 healthy Mexican women those 558 breast cancer (BC). frequencies observed controls patients BC were 38 45% for genotype, respectively. obtained odds ratio (OR) was 1.36, a 95% confidence interval...
The objective of this study was to examine the association between TNF-α serum levels and -308G>A -238G>A polymorphisms in corresponding gene by comparing healthy subjects colorectal cancer (CRC) patients from a Mexican population. Serum were found significantly differ CRC controls (P = 0.001), but no relationship increased risk established > 0.05). However, an variant disease became evident when distribution AA-GA genotypes examined with hematologic toxicity (neutropenia) those without...
The aim of this study was to associate FGFR4 rs1966265 and rs351855 variants with colorectal cancer (CRC) in a Mexican population perform silico analysis. Genomic DNA from 412 healthy individuals 475 CRC patients analyzed. In analysis performed using the PolyPhen-V2, GEPIA, GTEx, Cytoscape platforms. GA genotype dominant model (GAAA) AA recessive models were identified as risk factors (p < 0.05). aged ≥ 50 years at diagnosis who consumed alcohol had higher incidence than control group...
Pancreatic cancer (PC) is highly lethal, with KRAS mutations in up to 95% of cases. miRNAs inversely correlate expression, indicating potential as biomarkers. This study identified targeting and their impact on PC characteristics using silico methods. dbDEMC dysregulated PC; TargetScan, miRDB, PolymiRTS 3.0 specific for the gene; OncomiR evaluated association clinical survival PC. The correlation between was analysed ENCORI/starBase. A total 210 deregulated were (116 overexpressed 94...
In the last decades, it has been shown that inflammatory processes play a role in development of mental and physical problems; although some studies have researched relationship between inflammation psychological variables, inclusion biochemical variables as possible confounders limited. Therefore, aim this study was to determine whether are associated with marker, highly sensitive CRP (hs-CRP), after controlling for personal Mexican population. The performed at University Guadalajara...
Human adenovirus 36 (HAdV-36) has been associated with obesity and changes in glucose lipid metabolism. The virus reported to increase insulin sensitivity paradoxically promote weight gain. Because of its effects on metabolism, infection the could alter response several drugs used treat type 2 diabetes (DM2), such as metformin. aim this study was test whether HAdV-36 affects metformin a group obese patients DM2. Methods: In prospective cohort study, 103 newly diagnosed DM2 were divided into...
Background/Objectives. Colorectal cancer (CRC) is a multifactorial disease where the inflammatory state crucial. This study analyzes association of IL-1RN (rs2234663) and IL-1β (rs1143627, rs16944) variants levels with CRC. Methods. included 230 CRC patients 256 controls. Genotypes were determined by PCR plasma ELISA. RegulomeDB analyzed variants’ functional impacts, while OncoDB assessed expression’s influence on Results. The A1A1 genotype dominant pattern rs2234663 variant risk factors for...
Diabetic nephropathy is the single major cause of end stage renal failure. The increase visceral adipose tissue may lead to glomerular hypertrophy and chronic kidney disease. objective determine changes in diabetic Golden-Syrian Hamster (Mesocricetus auratus) supplemented with a hypercaloric diet. Methods: One group animals (n=10) was fed standard diet (SD), other (HCD) for 1 month. Afterwards, both groups were treated three doses Streptozotocin. Hyperglycemia determined throughout 73 days....
Dyslipidemia is a risk factor for cardiovascular disease and mortality; however, the association of this variable with wide range personal psychological variables has not been researched. Therefore, aim study was to compare lipid levels anthropometric measures between sexes determine atherogenic index (ARI). An adult population which auto-reported as healthy invited participate via social media in person. They filled out questionnaire variables; addition, body mass (BMI) waist-to-hip ratio...