A5021125419- Mitochondrial Function and Pathology
- Heat shock proteins research
- Digital Holography and Microscopy
- Sulfur Compounds in Biology
- Cell Image Analysis Techniques
- Genetics, Aging, and Longevity in Model Organisms
- Redox biology and oxidative stress
- Cerebrovascular and genetic disorders
- Diet and metabolism studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Folate and B Vitamins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Advanced Fluorescence Microscopy Techniques
- Alzheimer's disease research and treatments
- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- Neonatal and fetal brain pathology
Aarhus University
2022-2025
Aarhus University Hospital
2018-2024
Disturbances in microvascular flow dynamics are hypothesized to precede the symptomatic phase of Alzheimer's disease (AD). However, evidence presymptomatic AD remains elusive, underscoring need for therapies targeting these early vascular changes. We employed a multimodal approach, combining vivo optical imaging, molecular techniques, and ex magnetic resonance investigate capillary dysfunction C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax (Tg-SwDI) mice without memory impairment. also assessed...
Mitochondrial proteostasis is critical for cellular function. The molecular chaperone HSP60 essential cell function and dysregulation of expression has been implicated in cancer diabetes. few reported patients carrying gene variants show neurodevelopmental delay brain hypomyelination. Hsp60 interacts with more than 260 mitochondrial proteins but the functions affected by deficiency are poorly characterized.
Systemic inflammation affects cognitive functions and increases the risk of dementia. This phenomenon is thought to be mediated in part by cytokines that promote neuronal survival, but continuous exposure which may lead neurodegeneration. The effects systemic on cerebral blood vessels, their provision adequate oxygen support critical brain parenchymal cell functions, remains unclear. Here, we demonstrate neurovascular coupling profoundly disturbed lipopolysaccharide (LPS) induced awake mice....
High-contrast brightfield (HCBF) microscopy has emerged as a strong tool for noninvasive counting of cells in culture. HCBF imaging delivers precise cell growth data and is completely label free rendering it an attractive alternative to common procedures that often adversely affect growth. With computational image analysis, achieves efficient high-throughput automated workflows, extremely relevant drug chemical screens pharmaceutical, toxicological, biomedical research. We demonstrate the...
Summary Mitochondrial proteostasis is critical for cellular function and survival. HSP60 a molecular chaperone that interacts with more than 260 mitochondrial matrix proteins to assist in their folding few genetic variants of are compatible life. The reported human patients show phenotypes neurodevelopmental delay associated brain hypomyelination. It currently unknown how deficiency the links Here, we studied onset progression in: (1) mutation-inducible cell system, (2) skin fibroblasts from...
Disturbances in microvascular flow dynamics are hypothesized to precede the symptomatic phase of Alzheimer's disease (AD). However, evidence presymptomatic AD remains elusive, underscoring need for therapies targeting these early vascular changes.