A5017700236- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
- Neural Networks and Applications
- Barrier Structure and Function Studies
- Heart Rate Variability and Autonomic Control
- Optical Imaging and Spectroscopy Techniques
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Vascular Malformations Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Cerebrovascular and genetic disorders
- Acute Ischemic Stroke Management
- Receptor Mechanisms and Signaling
- Cell Image Analysis Techniques
- Cardiovascular and exercise physiology
- Cerebrovascular and Carotid Artery Diseases
- Thermoregulation and physiological responses
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
Aarhus University
2016-2025
Aarhus University Hospital
2010-2023
Cleveland Clinic
2009-2021
Technical University of Denmark
2008-2012
Danish National Research Foundation
2010-2012
Neurological Surgery
2011
Hvidovre Hospital
2010
Copenhagen University Hospital
2010
<h3>Context</h3> Both hallucinogens and 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") have direct agonistic effects on postsynaptic serotonin<sub>2A</sub>receptors, the key site for hallucinogenic actions. In addition, MDMA is a potent releaser reuptake inhibitor of presynaptic serotonin. <h3>Objective</h3> To assess differential hallucinogen use cerebral serotonin transporter (SERT) serotonin<sub>2A</sub>receptor binding. <h3>Design</h3> A positron emission tomography study 24 young...
Functional hyperemia reduces oxygen extraction efficacy unless counteracted by a reduction of capillary transit-time heterogeneity blood. We adapted bolus tracking approach to estimation for two-photon microscopy and then quantified changes in plasma mean transit time during forepaw stimulation anesthetized mice (C57BL/6NTac). In addition, we analyzed coefficient variance = heterogeneity/mean time, which expect remain constant passive, compliant microvascular networks. Electrical reduced,...
Brain imaging in Klinefelter syndrome (47, XXY) (KS), a genetic disorder characterized by the presence of an extra X chromosome, may contribute to understanding relationship between gene expression, brain structure, and subsequent cognitive disabilities psychiatric disorders. We conducted largest date voxel-based morphometry study 65 KS subjects controls matched for age education correlated these data neuropsychological test scores. The patients had significantly smaller total volume (TBV),...
The interpretation of regional blood flow and oxygenation changes during functional activation has evolved from the concept 'neurovascular coupling', hence regulation arteriolar tone to meet metabolic demands. efficacy oxygen extraction was recently shown depend on heterogeneity capillary patterns downstream. Existing compartment models relation between tissue metabolism, flow, oxygenation, however, typically assume homogenous microvascular patterns. To take into account, we modeled effect...
Disturbances in microvascular flow dynamics are hypothesized to precede the symptomatic phase of Alzheimer's disease (AD). However, evidence presymptomatic AD remains elusive, underscoring need for therapies targeting these early vascular changes. We employed a multimodal approach, combining vivo optical imaging, molecular techniques, and ex magnetic resonance investigate capillary dysfunction C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax (Tg-SwDI) mice without memory impairment. also assessed...
Abstract Background The high mortality and morbidity after SAH is partly due to DCI, which traditionally ascribed development of angiographic vasospasms. This relation has been challenged, capillary flow disturbances are proposed as another mechanism contributing brain damage . Objective To investigate changes 4 days following experimental Methods was induced by endovascular perforation circle Willis. We used TPM evaluate blood characteristics. Cortical diameters were investigated both...
Ischemic conditioning and exercise have been suggested for protecting against brain ischemia-reperfusion injury. However, the endogenous protective mechanisms stimulated by these interventions remain unclear. Here, in a comprehensive translational study, we investigated role of extracellular vesicles (EVs) released after remote ischemic (RIC), blood flow restricted resistance (BFRRE), or high-load (HLRE). Blood samples were collected from human participants before at serial time points...
Abstract Objective Theoretical models are essential tools for studying microcirculatory function. Recently, the validity of a well‐established phase separation model was questioned and it claimed that produces problematically low hematocrit predictions lack red cells in small diameter vessels. We conducted quantitative evaluation this to establish common ground future research. Methods Model were validated against comprehensive database with measurements from 4 mesenteric networks. A...
Capillary flow patterns are highly heterogeneous in the resting brain. During hyperemia, capillary transit-time heterogeneity (CTH) decreases, proportion to blood's mean transit time (MTT) passive, compliant microvascular networks. Previously, we found that functional activation reduces CTH:MTT ratio, suggesting additional homogenization takes place through active neurocapillary coupling mechanisms. Here, examine changes ratio during hypercapnic hyperemia anesthetized mice (C57Bl/6NTac),...
Abstract APOE-ɛ4 is a genetic risk factor for Alzheimer's disease (AD). AD associated with reduced cerebral blood flow (CBF) and microvascular changes that limit the transport of oxygen from into brain tissue: volume high relative transit time heterogeneity (RTH). Healthy carriers reveal regions elevated CBF compared common ɛ3 allele. Such asymptomatic hyperemia may reflect dysfunction: vascular entity characterized by suboptimal tissue uptake, rather than limited per se. Here, we used...
ABSTRACT Objective In vivo imaging of the microcirculation and network‐oriented modeling have emerged as powerful means studying microvascular function understanding its physiological significance. Network‐oriented may provide summarizing vast amounts data produced by high‐throughput techniques in terms key, indices. To estimate such indices with sufficient certainty, however, analysis must be robust to inevitable presence uncertainty due measurement errors well model errors. Methods We...
Large amounts of neuroimaging studies are collected and have changed our view on human brain function.By integrating multiple in meta-analysis a more complete picture is emerging.Brain locations usually reported as coordinates with reference to specific atlas, thus some the databases offer socalled coordinate-based searching users (e.g.Brede, BrainMap).For such search, publications, which relate represented by user coordinates, retrieved.In this paper we present BredeQuery -a plugin for...