A5082106555- Muscle metabolism and nutrition
- Physiological and biochemical adaptations
- Sports Performance and Training
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Cardiomyopathy and Myosin Studies
- Turtle Biology and Conservation
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Amphibian and Reptile Biology
- Heart Rate Variability and Autonomic Control
- Pharmacological Effects and Assays
- Aquaculture disease management and microbiota
- Genetic Neurodegenerative Diseases
- Photoacoustic and Ultrasonic Imaging
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Bat Biology and Ecology Studies
- Adipose Tissue and Metabolism
- Zebrafish Biomedical Research Applications
Aarhus University
2016-2025
Purpose: It is well established that high-load resistance exercise (HLRE) can stimulate myofibrillar accretion. Additionally, recent studies suggest HLRE also mitochondrial biogenesis and respiratory function. However, in several clinical situations, the use of with high loading may not constitute a viable approach. Low-load blood flow restricted (BFRRE) has emerged as time-effective low-load alternative to unknown if BFRRE If so, could provide feasible strategy muscle metabolic health....
Snakes exhibit remarkable physiological shifts when their large meals induce robust postprandial growth after prolonged fasting. To understand the regulatory mechanisms underlying this rapid metabolic transition, we examined regulation of protein synthesis in pythons, focusing on processes driving early tissue remodeling and growth. Using SUnSET method with puromycin labeling, measured vivo fasting digesting snakes at multiple post-feeding intervals. Pyloric ligation, pancreatectomy, plasma...
Purpose: High-load resistance exercise contributes to maintenance of muscle mass, protein quality, and contractile function by stimulation synthesis (MPS), hypertrophy, strength gains. However, high loading may not be feasible in several clinical populations. Low-load blood flow restricted (BFRRE) provide an alternative approach. the long-term synthetic response BFRRE is unknown myocellular adaptations prolonged are well described. Methods: To investigate this, 34 healthy young subjects were...
Ischemic conditioning and exercise have been suggested for protecting against brain ischemia-reperfusion injury. However, the endogenous protective mechanisms stimulated by these interventions remain unclear. Here, in a comprehensive translational study, we investigated role of extracellular vesicles (EVs) released after remote ischemic (RIC), blood flow restricted resistance (BFRRE), or high-load (HLRE). Blood samples were collected from human participants before at serial time points...
Abstract Aim mTORC1 is regarded as an important key regulator of protein synthesis and hypertrophy following mechanical stimuli in skeletal muscle. However, excitation tension development tightly coupled most experimental models, very little largely indirect evidence exist for such a mechanosensitive pathway. Here, we sought to examine whether activation signalling dependent on per se rat Methods To the mechanosensitivity mTORC1, EDL muscles were exposed either excitation‐induced eccentric...
Abstract Aim Loading‐induced tension development is often assumed to constitute an independent cue initiate muscle protein synthesis following resistance exercise. However, with traditional physiological models of exercise, changes in loading‐induced also reflect neural activation patterns, and direct evidence for a mechanosensitive mechanism therefore limited. Here, we sought examine the importance excitation per se on initiation signalling, gene transcription rat skeletal muscle. Methods...
The Burmese python has a remarkable digestive physiology with large elevations of metabolic rate and heart following feeding. Here, we describe the relationship between rate, oxygen consumption, core body temperature during digestion in five pythons (Python bivittatus) by implantation data loggers. snakes were placed respirometers at 30±0.1°C for 26 days voluntarily ingested three meals different size, whilst temperature, consumption rates measured continuously. Both increased several-fold...
Abstract Contractile function of skeletal muscle relies on the ability fibers to trigger and propagate action potentials (APs). These electrical signals are created by transmembrane ion transport through channels membrane transporter systems. In this regard, Cl- channel 1 (ClC-1) Na+/K--ATPase (NKA) central for maintaining homeostasis across sarcolemma during repetitive AP firing inherent intense contractile activity. Therefore, randomized controlled trial (RCT) aimed investigate changes in...