A5037048785- Barrier Structure and Function Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer therapeutics and mechanisms
- Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Characterization and Applications of Magnetic Nanoparticles
- Microfluidic and Capillary Electrophoresis Applications
- Optical Imaging and Spectroscopy Techniques
- Metabolomics and Mass Spectrometry Studies
- Cerebrovascular and genetic disorders
- Retinal Imaging and Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Optical Coherence Tomography Applications
Aarhus University
2015-2024
University of Chinese Academy of Sciences
2021-2022
Sino-Danish Centre for Education and Research
2021-2022
Disturbances in microvascular flow dynamics are hypothesized to precede the symptomatic phase of Alzheimer's disease (AD). However, evidence presymptomatic AD remains elusive, underscoring need for therapies targeting these early vascular changes. We employed a multimodal approach, combining vivo optical imaging, molecular techniques, and ex magnetic resonance investigate capillary dysfunction C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax (Tg-SwDI) mice without memory impairment. also assessed...
Systemic inflammation affects cognitive functions and increases the risk of dementia. This phenomenon is thought to be mediated in part by cytokines that promote neuronal survival, but continuous exposure which may lead neurodegeneration. The effects systemic on cerebral blood vessels, their provision adequate oxygen support critical brain parenchymal cell functions, remains unclear. Here, we demonstrate neurovascular coupling profoundly disturbed lipopolysaccharide (LPS) induced awake mice....
Rapid and reliable diagnosis is essential in the fight against malaria, which remains one of most deadly infectious diseases world. In present study we take advantage a droplet microfluidics platform combined with novel user-friendly biosensor for revealing main malaria-causing agent, Plasmodium falciparum (P. falciparum) parasite. Detection parasite achieved through detection activity parasite-produced DNA-modifying enzyme, topoisomerase I (pfTopoI), blood from malaria patients. The assay...
Disturbances in microvascular flow dynamics are hypothesized to precede the symptomatic phase of Alzheimer's disease (AD). However, evidence presymptomatic AD remains elusive, underscoring need for therapies targeting these early vascular changes.
Abstract Optical coherence tomography (OCT) is applicable to the study of cerebral microvasculature in vivo . Optimised acquisition schemes enable generation three-dimensional OCT angiograms, i e ., volumetric images red blood cell flux capillary networks, currently at a repetition rate up 1/10 seconds. This makes testable new class hypotheses that strive bridge gap between microscopic phenomena occurring spatial scale neurons, and less invasive but crude techniques measure macroscopic flow...
Abstract Background Alzheimer’s disease (AD) shares many risk factors with cardiovascular diseases, and much evidence shows that AD involves a cerebrovascular component. patients display disturbances in brain hemodynamics characterized by decreased cerebral blood flow (CBF) during steady‐state conditions. It has been suggested capillary stalls heavily impact the CBF of animal models. Increased stalling time may impair patterns, reducing oxygen availability to tissue. Previous studies have...
Alzheimer's disease (AD) shares many risk factors with cardiovascular diseases and much evidence shows that AD involves a cerebrovascular component. Amyloid beta (Aβ) is neurotoxic, upregulated during hypoxia damages the brain's microvasculature. Oxygen availability extraction depend overall on regional cerebral blood flow (rCBF) as well distribution of across Damages to brain microvasculature alter microvascular flows (capillary dysfunction) resulting in decreased oxygen availability....