A5033156784- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- HIV Research and Treatment
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Peptidase Inhibition and Analysis
- Meningioma and schwannoma management
- Synthesis and Biological Evaluation
- Facial Nerve Paralysis Treatment and Research
- Antibiotic Use and Resistance
- Trigeminal Neuralgia and Treatments
- HIV-related health complications and treatments
- Antibiotic Resistance in Bacteria
- Click Chemistry and Applications
- Iron Metabolism and Disorders
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Acute Lymphoblastic Leukemia research
- Protease and Inhibitor Mechanisms
- Antifungal resistance and susceptibility
Université Paris Cité
2014-2024
Inserm
2015-2024
Sorbonne Paris Cité
2015-2024
Servier (France)
2024
Institut des Hautes Études Scientifiques
2024
Délégation Paris 7
2015-2020
Hôpital Bichat-Claude-Bernard
2016-2017
Infection, Anti-microbiens, Modélisation, Evolution
2014-2017
Université Claude Bernard Lyon 1
2016-2017
Assistance Publique – Hôpitaux de Paris
2016-2017
Background In 2014–2015, we assessed favipiravir tolerance and efficacy in patients with Ebola virus (EBOV) disease (EVD) Guinea (JIKI trial). Because the drug had never been used before for this indication that high concentrations of drugs were needed to achieve antiviral against EBOV, a pharmacokinetic model propose relevant dosing regimen. Here report plasma achieved participants JIKI trial put them perspective model-based targeted concentrations. Methods findings Pre-dose collected at...
Background Despite repeated outbreaks, in particular the devastating 2014–2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among drug candidates broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile EVD (JIKI trial) but did not demonstrate strong antiviral efficacy. In order to gain new insights into efficacy of favipiravir and improve preparedness public health management future we assess achieved by...
Significance In light of the recent outbreak Zika virus (ZIKV), an understanding within-host viral dynamics is essential to assess persistence in vivo, transmission risk, and antiviral therapeutics. Using mathematical modeling we find that, nonhuman primates, ZIKV are characterized by a short lifetime infected cells (<10 h) during which enough particles produced infect ∼11 other cells. Higher disease burden associated with changes natural killer cell subset concentrations elevated...
Favipiravir is an RNA polymerase inhibitor that showed strong antiviral efficacy in vitro and small-animal models of several viruses responsible for hemorrhagic fever (HF), including Ebola virus. The aim this work was to characterize the complex pharmacokinetics favipiravir nonhuman primates (NHPs) order guide future studies large-animal models. Four different were conducted 30 uninfected cynomolgus macaques Chinese (n = 17) or Mauritian 13) origin treated with intravenous 7 14 days...
Despite several clinical trials implemented, no antiviral drug could demonstrate efficacy against Ebola virus. In non-human primates, early initiation of polymerase inhibitors favipiravir and remdesivir improves survival, but whether they be effective in patients is unknown. Here we analyze the impact therapy by using a mathematical model that integrates virological immunological data 44 cynomolgus macaques, left untreated or treated with favipiravir. We estimate has ~50% blocking viral...
While most individuals suffer progressive disease following HIV infection, a small fraction spontaneously controls the infection. Although CD8 T-cells have been implicated in this natural control, their mechanistic roles are yet to be established. Here, we combined mathematical modeling and analysis of previously published data from 16 SIV-infected macaques, which 12 were controllers, elucidate role control. For each macaque, considered, addition canonical vivo plasma viral load SIV DNA...
Obesity has high prevalence among HIV-infected patients. Increased adipose tissue mass affects the pharmacokinetics of numerous drugs, but few data are available for antiretroviral drugs.In this study we aimed to explore drugs and immuno-virological response in obese patients with HIV infection.We examined from 2009 2012 our hospital's database HIV-1-infected who received an drug (abacavir, emtricitabine, lamivudine, tenofovir, efavirenz, etravirine, nevirapine, atazanavir/ritonavir,...
Highly efficient CD8+ T cells are associated with natural HIV control, but it has remained unclear how these generated and maintained. We have used a macaque model of spontaneous SIVmac251 control to monitor the development cell responses. Our results show that SIV-specific emerge during primary infection in all animals. The ability suppress SIV is suboptimal acute phase increases progressively controller macaques before establishment sustained low-level viremia. Controller develop optimal...
Ebola virus has been responsible for two major epidemics over the last several years and there a strong effort to find potential treatments that can improve disease outcome. Antiviral favipiravir was thus tested on non-human primates infected with virus. Half of treated animals survived challenge, whereas infection fully lethal untreated ones. Moreover, did not survive died later than controls. We evaluated hematological, virological, biochemical, immunological parameters performed proteomic...
Alpha- 1-antitrypsin (A1AT) deficiency is a hereditary autosomal codominant genetic disorder resulting in low circulating levels of A1AT and leading to lung and/or liver disease. It remains underdiagnosed only 5 10% PIZZ patients, the most common form severe deficiency, would be actually identified France. Facilitating early diagnosis allow better management this disease; therefore we have developed standardized three laboratories involved study, diagnostic test on dried blood spots (DBS)...
ABSTRACT While most individuals suffer progressive disease following HIV infection, a small fraction spontaneously controls the infection. Although CD8 T-cells have been implicated in this natural control, their mechanistic roles are yet to be established. Here, we combined mathematical modeling and analysis of data from 16 SIV-infected macaques, which 12 were controllers, elucidate role control. For each macaque, considered, addition canonical vivo plasma viral load SIV DNA data,...
ABSTRACT Highly efficient virus-specific CD8 + T-cells are associated with immune control of HIV infection, but it remains unclear how these cells generated and maintained over time. We used a macaque model spontaneous SIVmac251 infection to monitor the development evolution potent antiviral T-cell responses. SIV-specific emerged during primary in all animals. However, ability T suppress SIV replication was low early stages increased after period maturation, temporally linked establishment...
Abstract SIVmac 251 -infected Mauritius cynomolgus macaques presenting a M6 MHC haplotype or challenged with low inoculum dose by mucosal route are models for natural HIV control. Here we characterized modeling the dynamics of plasma SIV-RNA and SIV-DNA in blood cells 16 ANRS SIC study. kinetics was best fitted using model where cytotoxic immune response progressively mounted up reduced actively infected half-life (t 1/2 ) from 5.5 days early on to about 0.3 days. The predicted that control...