The primary structure of the zeta subspecies rat brain protein kinase C was deduced from its overlapping cDNAs. consists 592 amino acid residues with calculated molecular mass 67,740 Da and has regulatory domains in amino- carboxyl-terminal halves, respectively. Although all members family so far identified have a tandem repeat characteristic cysteine-rich zinc-finger-like sequence domain, contains only one set this sequence. Northern (RNA)-blot hybridization analysis indicated that two...

Objective To assess whether the presence of structural osteoarthritis (OA) features over as many 4 years prior to incident radiographic OA increases risk in a nested, case–control design. Methods We studied 355 knees from Osteoarthritis Initiative cohort that developed before 48‐month visit. They were matched one‐to‐one by sex, age, and contralateral knee status with control knee. Magnetic resonance images (MRIs) read for bone marrow lesions (BMLs), cartilage damage, meniscal damage...

Musculoskeletal symptoms such as neck and shoulder pain/stiffness low back pain are common health problems in the working population. They leading causes of presenteeism (employees being physically present at work but unable to be fully engaged). Recently, digital interventions have begun used manage their effectiveness has not yet been verified, adherence programs is always a problem.This study aimed evaluate improvements musculoskeletal workers with neck/shoulder stiffness/pain after use...

Two forms of storage proteins termed SP 1 and 2, respectively, accumulate in a stage-dependent fashion the larval hemolymph silkworm Bombyx mori. We have cloned analyzed genomic sequence encoding an arylphorin-type protein. The 2 structural gene contains five exons spanning over 5 kilobases chromosomal DNA. transcription initiation site was identified at nucleotide level typical TATA box located 30 base pairs upstream site. 5'-flanking region homologous to SV 40 enhancer core structure. A...

Although it is understood that work-related factors, including job demands, control, and workplace support, are associated with workers' health well-being, the role played by personal characteristics, especially workaholism, has not been fully investigated. This study examined workaholism's associations psychological ill health, low back pain disability, sickness absence among Japanese workers.A cross-sectional Internet survey was conducted using self-administered questionnaires. Data from...

Changes in working styles and physical activities, an increase psychological stress during the coronavirus disease 2019 (COVID-19) pandemic, may have affected pain conditions among workers with pain; however, these associations are still poorly understood. Therefore, we conducted a web-based, cross-sectional study to investigate changes Japanese suffering from pain. A total of 1941 who were aged 20–64 years suffered body within 4 weeks prior included. Information was collected using...

Recent molecular cloning analysis has shown that protein kinase C is a family of multiple subspecies having closely related structures (1-7).The four a,

Abstract A major plasma protein termed SP 1 accumulates in a sex- and stage-specific manner the larval hemolymph of silkworm, Bombyx mori. We have cloned genomic sequence coding for analyzed its primary structure. The mRNA is encoded by five exons interspersed with four introns. Initiation site gene transcription was identified at nucleotide level. Sequence homologous to SV 40 enhancer core structure exists two adjacent locations first intron. 5' flanking region contains highly putative...

Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different approaches have not compared. We performed first comparative trial three types (medication with acetaminophen, exercise, and acupuncture) in Japanese patients LSS. Patients L5 root radiculopathy associated LSS who visited our hospital surgical treatment were enrolled between December 2011 January 2014. In this open-label study, assigned to groups (medication, according visit time....

Depression is a relevant risk factor for low back pain and associated with the outcomes of pain. also often overlaps somatisation. As previous studies have suggested that somatisation or higher somatic symptom burden has role in pain, aim present cross-sectional study was to examine whether health-related quality life individuals chronic independent depression. We analyzed internet survey data on physical mental health Japanese adults aged 20–64 years (n = 3,100). Health-related assessed...

High prevalence of low back pain (LBP) in nurses has been reported globally. Ergonomic factors and work-related psychosocial have focused on as risk factors. However, evidence the role fear-avoidance beliefs (FABs) concerning LBP is lacking. This study examined association between FABs chronic disabling that interfered with work lasted ≥ 3 months.Female (N = 3066; mean age 35.8 ± 10.6 years) from 12 hospitals Japan participated. A self-reported questionnaire was used to collect information...

Background Although poor standing posture is a known cause of low back pain, the mechanisms involved are unclear. The aim this study was to clarify kinetic and angle features that might influence pain. Methods Sixty-seven young men were enrolled in cross-sectional case-control categorized according whether they did or not have Habitual assessed each group, using three-dimensional motion analysis system, force plates, spinal mouse. Kinetic factors compared between participants with without...

Diagnosis of cervical spine injury (CSI) is difficult in patients with an altered level consciousness as a result traumatic brain (TBI). Patients TBI and older adults are at increased risk for CSI. This study examined the various factors CSI among trauma whether who were (≥55 years) higher when they sustained fall-related TBI.Data used was 2007 National Trauma Data Bank (NTDB), Sample Project (NSP) TBI. dataset contains admission records from 82 I II centers. Logistic regression to identify...

Objective The present study was undertaken to assess whether the odds for incident radiographic osteoarthritis (OA) differ between men and women in regard body mass index (BMI) inflammatory magnetic resonance imaging (MRI) markers 1 2 years prior, presence of inflammation on MRI differs normal‐weight overweight/obese individuals who develop OA up 4 prior. Methods We studied 355 knees from Osteoarthritis Initiative that developed matched controls. MRIs were read effusion‐synovitis...

To investigate the distribution of 25-question Geriatric Locomotive Function Scale (GLFS-25) scores in Japanese rheumatoid arthritis (RA) patients and evaluate relationships with clinical variables.Among 15,115 registered NinJa database for fiscal year 2015, 1710 complete GLFS-25 disease activity score-28 (DAS28) data were analyzed. Correlations between score variables assessed by Spearman coefficients. Mean compared among DAS28 groups (<2.6, 2.6-3.1, 3.2-5.0, ≥5.1) using Kruskal-Wallis...

The risk of falls among adults with knee osteoarthritis (OA) has been documented, yet, to our knowledge no studies have examined OA and the medically treated injurious (overall by sex), which is an outcome substantial clinical public health relevance.Using data from Health Aging Body Composition Knee Osteoarthritis Substudy, a community-based study white African American older adults, we tested associations between status 734 participants mean ± SD age 74.7 2.9 years. radiographic (ROA) was...

Although the occupational health field has identified psychosocial factors as risk for low back pain that causes disability, association between disabling and not been examined adequately in Japanese hospital workers. Therefore, this study pain, which interfered with work, workers.This cross-sectional was conducted at a Japan. In total, 280 workers were recruited from various settings. Of these, 203 completed self-administered questionnaire included items concerning individual...