Exogenous reactive oxygen species (ROS) produced by nanobubble (NB) water offer a reasonable explanation for NBs' physiological promotion and oxidation effects. To develop exploit the NB technology, we have performed further research to identify specific ROS NBs. Using fluorescent reagent APF, Fenton reaction, dismutation reaction of superoxide dismutase DMSO, distinguished four types (superoxide anion radical (O2·-), hydrogen peroxide (H2O2), hydroxyl (·OH), singlet (1O2)). ·OH was...

Several studies have shown that normal weight with central obesity (NWCO) is associated cardiovascular disease risk factors such as hypertension, dyslipidemia and diabetes. However, the relationship between NWCO hyperuricemia has not been studied in detail.We investigated association among Japanese adults aged 40-64 years who had undergone periodic health examinations April 2013 March 2014. Obesity was defined a body mass index (BMI) ≥25 kg/m2 determined waist-to-height ratio (WHtR) ≥0.5. We...

To identify the primary health conditions that cause presenteeism, and to estimate economic cost of lost productivity due presenteeism in Japan.We conducted an Internet survey among 10,000 Japanese workers. Participants were asked answer condition most affecting their work. Presenteeism was evaluated using Quantity Quality methods, we estimated annualized per capita nation.The common interfering with work neck pain or stiff shoulders, low back pain, mental illnesses. The costs for each...

Several studies have shown that normal weight central obesity (NWCO) is associated with cardiovascular disease (CVD) risk factors. However, conducted in the Japanese population been very limited. Thus, relationships between obesity, classified using body mass index (BMI), waist-to-height ratio (WHtR), and CVD factors middle-aged adults were investigated.The participants aged 40-64 years who had undergone periodic health examinations Japan during period from April 2013 to March 2014. The...

Changes in working styles and physical activities, an increase psychological stress during the coronavirus disease 2019 (COVID-19) pandemic, may have affected pain conditions among workers with pain; however, these associations are still poorly understood. Therefore, we conducted a web-based, cross-sectional study to investigate changes Japanese suffering from pain. A total of 1941 who were aged 20–64 years suffered body within 4 weeks prior included. Information was collected using...

The aim of this pilot study was to investigate the feasibility high-speed gait training with an exoskeleton robot hybrid assistive limb (HAL) in patients chronic stroke, and examine efficacy eight sessions (8 weeks) a HAL compared conventional physical therapy. Eighteen stroke were included (nine each control groups). group underwent once week for 8 weeks (20 min/session). therapy disturbance. Outcome measures walking speed, number steps, cadence during 10 m test, timed up go functional...

Abstract Objectives This study investigated the common health conditions leading to presenteeism and economic impact among Japanese workers in post-COVID-19 era. Methods Between February March 2023, 10,000 responded a web-based, cross-sectional survey on problems that interfered with their work, degree of presenteeism, teleworking status. Results Approximately 35.6% faced impacted work. The primary were low back pain, neck pain/stiff shoulders, mental illness, which varied slightly age work...

Cytomegalovirus (CMV) can cause life-threatening diseases in immunosuppressed patients. Some of the patients with connective tissue disease develop CMV infection, and approximately half this group has been reported to have received pulsed-methylprednisolone (p-MPSL) therapy. This study aimed identify predictors onset infection receiving p-MPSL therapy for disease. was a retrospective, multicenter cohort study. We included who had antigenemia measured between April 2011 December 2020....

Abstract Objectives: Teleworking from home was widespread during the 2019 coronavirus disease pandemic. This working practice is expected to maintain popularity among employers and employees. Compared with in-person workers, teleworkers tend be less physically active have more musculoskeletal pain. Interventions specific reducing health risks not been identified. study examined effects of an occupational lifestyle intervention encompassing three components: physical activity promotion,...

Alanine aminotransferase (ALT) and aspartate (AST) to ALT ratio (AST/ALT ratio) have been shown be related non-alcoholic fatty liver disease or insulin resistance, which was associated with chronic kidney (CKD). However, it is unclear whether AST/ALT are CKD. In this study, we examined the relationship of CKD among middle-aged females in Japan.The present study included 29,133 women aged 40 64 years who had an annual health checkup Japan during April 2013 March 2014. Venous blood samples...

Abstract It has been postulated that physical immobilization is an essential factor in developing chronic pain after trauma or surgery extremity. However, the mechanisms of sustained immobilization‐induced remain poorly understood. The present study, therefore, aimed to develop a rat model for post‐cast ( CPCP ) and clarify mechanism(s) underlying . To investigate effects cast on behaviours rats, one hindlimb was immobilized 2 weeks with remobilization conducted 10 weeks. Cast induced muscle...

Although the occupational health field has identified psychosocial factors as risk for low back pain that causes disability, association between disabling and not been examined adequately in Japanese hospital workers. Therefore, this study pain, which interfered with work, workers.This cross-sectional was conducted at a Japan. In total, 280 workers were recruited from various settings. Of these, 203 completed self-administered questionnaire included items concerning individual...

The thyroid hormones have been reported to be associated with cognitive decline and Alzheimer's disease. relationship between function within the normal range cerebral blood flow in disease patients has shown a recent study. Mild impairment is often first stage of disease; thus, early diagnosis important. present study investigated regional mild A total 122 memory clinic outpatients who underwent testing single photon emission computed tomography were divided into impairment, disease, Normal...

Hydrogen water as a new therapeutic antioxidant has been widely used in living organisms under stress. In this study, we applied nanobubble (NB) technology to hydrogen water. The capacity of NB was studied with respect different reactive oxygen species (ROS) both vitro and vivo. Using relatively weak reduced dye, APF, showed that can effectively remove three cytotoxic ROS, •OH, ClO-, ONOO-, from could also O2•-, which is physiologically important However, not reduce other ROS such H2O2 NO....

In this study, after confirming the suppression of autonomic nervous function by isoflurane anesthesia using antagonists, we pharmacologically investigated involvement vasomotor and cardiac sympathetic functions in systolic blood pressure variability (SBPV) frequency components conscious rats at rest during exposure to low-ambient temperature (LT-exposure, 9°C for 90 min). Under unanesthesia, phentolamine administration (α-adrenoceptor antagonist, 10 mg/kg) decreased mid-frequency component...

Pain drawings have frequently been used for documentation of pain and a convenient diagnosis tool. were found to be associated with psychological states in chronic patients low back pain. Few researchers investigated except The aim this study was investigate the pain, drawings, characteristics, interference head, neck-shoulder (NS), low-back/lower-limb (LB-LL) regions among pain.We included total 291 new (headache, 62; NS 87; LB-LL 142). scores 10-cm Visual Analogue Scale (VAS), Hospital...

Abnormal lipid levels have been suggested as a mechanism leading to atherosclerosis of the lumbar vessels, resulting in low back pain (LBP). This study examined whether abnormal were associated with LBP among middle-aged adults Japan.The present included between 40 and 64 years old who underwent an annual health checkup. A total 258,367 eligible participants analyzed investigate associations low-density lipoprotein cholesterol (LDL-C), high-density (HDL-C), LDL-C/HDL-C ratio. Participants...

Background: In the present study, we examined spinal glial cell activation as a central nervous system mechanism of widespread mechanical hyperalgesia in rats that experienced chronic post-cast pain (CPCP) 2 weeks after cast immobilization. Activated microglia and astrocytes were investigated immunohistologically lumbar coccygeal cord segments 1 day, 5 weeks, 13 following removal. Results: cord, activated microglia. Astrocytes also but with delay was longer than observed cord. This pattern...

A decrease in work productivity due to presenteeism among healthcare workers with low back pain (LBP) is a major problem the workplace. It important determine factors associated successfully manage nursing staff LBP. This study aimed identify personnel LBP through evaluation of several aspects, including individual, occupational, and psychological factors.We conducted cross-sectional 668 who had experienced within 4 weeks before enrollment at tertiary hospital Japan. Information on...

Although some recent studies have indicated an association between metabolic syndrome (MetS) and musculoskeletal disease, little is known about the of MetS with low back pain (LBP). The present study aimed to investigate sex differences in clustering components LBP among middle-aged Japanese individuals. Study subjects were 45,192 adults (30,695 men, 14,497 women) aged 40–64 years who underwent annual health checkups conducted from April 2013 March 2014. was defined according criteria...

Purpose: Care workers at nursing care facilities have high rate of low back pain (LBP). Although increasing evidence has revealed the important role psychosocial factors in chronic LBP, associated with LBP interfering work not been fully investigated Japanese facilities. The present study aimed to determine prevalence and related including factors, among Material methods: Eligible participants were 95 Ishikawa Prefecture (n=2,242). Of these, 1,345 completed a self-administered questionnaire...

Low back pain (LBP) is a common cause of disability among nursing personnel. Although many studies regarding the risk factors for LBP staff have focused on physical load at work, multidimensional assessments are essential to identify appropriate preventive strategies. We aimed investigate association (individual, physical, psychological and occupational) with disabling personnel in Japan.Observational study comparative cross-sectional design.Data were collected using self-administered...