A5074672569- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Plant Molecular Biology Research
- Cholinesterase and Neurodegenerative Diseases
- Photosynthetic Processes and Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Light effects on plants
- Cerebrospinal fluid and hydrocephalus
- Genomics, phytochemicals, and oxidative stress
- Antioxidant Activity and Oxidative Stress
- Plant Reproductive Biology
- Metastasis and carcinoma case studies
- Functional Brain Connectivity Studies
- Folate and B Vitamins Research
- Phosphodiesterase function and regulation
- Neuroscience and Neuropharmacology Research
- Plant tissue culture and regeneration
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Gastroesophageal reflux and treatments
- Neurosurgical Procedures and Complications
- Leaf Properties and Growth Measurement
- Medical Imaging and Pathology Studies
Waseda University
2020-2025
Showa University Northern Yokohama Hospital
2024
Showa University
2007-2023
Kagoshima University
2014-2019
University of Turin
2012
National Institute for Basic Biology
2005-2010
Osaka University
2001-2007
Tokyo University of Science
2007
National Institutes of Natural Sciences
2005
The subject of this paper, sun leaves are thicker and show higher photosynthetic rates than the shade leaves, is approached in two ways. first seeks to answer question: why leaves? To do this, CO2 diffusion within a leaf examined first. Because affinity Rubisco for low, carboxylation ribulose 1,5-bisphosphate competitively inhibited by O2, oxygenation leads energy-consuming photorespiration, it essential C3 plants maintain concentration chloroplast as high possible. Since internal...
Regulation of cell number and size is essential for controlling the shape leaves. Here, we report a novel class Arabidopsis thaliana mutants, more smaller cells 1 (msc1)-msc3, which have increased decreased in msc1 has miR156-resistant mutation SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 15 (SPL15) gene. msc2 msc3 are new alleles paused squint respectively. All msc mutants showed accelerated heteroblasty, phenomenon several morphological traits leaves change along with phase change. Consistent...
Abstract In multicellular organisms, the coordination of cell proliferation and expansion is fundamental for proper organogenesis, yet molecular mechanisms involved in this are largely unexplored. plant leaves, existence suggested by compensation, which a decrease number triggers an increase mature size. To elucidate we isolated five new Arabidopsis (Arabidopsis thaliana) mutants (fugu1–fugu5) that exhibit compensation. These were characterized together with angustifolia3 (an3), erecta (er),...
Objective The objective of this study was to identify new causes Charcot–Marie–Tooth (CMT) disease in patients with autosomal‐recessive (AR) CMT. Methods To efficiently novel causative genes for AR‐CMT, we analyzed 303 unrelated Japanese CMT using whole‐exome sequencing and extracted recessive variants/genes shared among multiple patients. We performed mutation screening the newly identified membrane metalloendopeptidase ( MME ) gene 354 additional clinically, genetically, pathologically,...
Amyloid β-protein (Aβ) molecules tend to aggregate and subsequently form low MW (LMW) oligomers, high (HMW) aggregates such as protofibrils, ultimately fibrils. These Aβ species can generally amyloid plaques implicated in the neurodegeneration of Alzheimer disease (AD), but therapies designed reduce plaque load have not demonstrated clinical efficacy. Recent evidence implicates oligomers AD neuropathology, precise mechanisms are uncertain. We examined neuronal dysfunction from HMW-Aβ1-42...
There is an urgent need to establish blood biomarkers for Alzheimer's disease (AD). Although it has been speculated that brain-derived neurotrophic factor (BDNF) associated with AD, whether can be used as a biomarker yet determined. We serum, cerebrospinal fluid (CSF), and medial temporal lobe atrophy from patients AD evaluate the association of BDNF assess its severity. For analysis, 66 participants [21 normal controls (NCs) cognitive function, 22 mild impairment (MCI) due 23 AD] were...
Physiological and ecological characteristics of sun shade leaves have been compared in detail, but their developmental processes, particular light sensory mechanisms, are still unknown. This study compares the development Chenopodium album L., paying special attention to site. We hypothesized that mature sense environment, this information determines anatomy new leaves. To examine hypothesis, we shaded plants partially. In low-light apex treatment (LA), shoot with developing was covered by a...
Lonicera caerulea L. berry polyphenols (LCBP) are considered as major components for bioactivity. This study aimed to clarify the molecular mechanisms by monitoring inflammatory and antioxidant mediator actions in lipopolysaccharide (LPS)-induced mouse paw edema macrophage cell model. LCBP significantly attenuated LPS-induced (3.0 ± 0.1 2.8 mm, P < 0.05) reduced (P serum levels of monocyte chemotactic protein-1 (MCP-1, 100.9 2.3 58.3 14.5 ng/mL), interleukin (IL)-10 (1596.1 424.3 709.7 65.7...
ABSTRACT The authors’ previous study of Chenopodium album L. revealed that the light signal for anatomical differentiation sun and shade leaves is sensed by mature leaves, not developing leaves. They suggested two‐cell‐layered palisade tissue would be formed without a change in total cell number. To verify suggestion, detailed was made developmental processes C. with respect to division cells (PCs) data expressed against time (leaf plastochron index, LPI). number PCs per leaf did differ...
Nutritional epidemiology has shown that inadequate dietary protein intake is associated with poor brain function in the elderly population. The plasma free amino acid (PFAA) profile reflects nutritional status and may have potential to predict future changes cognitive function. Here, we report results of a 2-year interim analysis 3-year longitudinal study following mild impairment (MCI) participants.In multicenter prospective cohort design, MCI participants were recruited, fasting samples...
ABSTRACT Spermine (SPM) and spermidine (SPD) are polyamines found in all organisms, their concentrations can be regulated by ingestion. We demonstrated that yeast‐fermented garlic (YF) extract significantly increased autophag flux OUMS‐36T‐1 HeLa cells expressing the fluorescent probe (GFP‐LC3‐RFP‐LC3ΔG). YF‐induced increase of autophagy occurred independently mTORC1 signaling, RNA‐sequencing analysis revealed EGR1 was most altered gene YF‐treated cells. EGR1‐ deficient HAP1 displayed...
Abstract A chloroplast signal recognition particle (SRP) that is related to the SRP involved in secretion bacteria and eukaryotic cells used for insertion of light-harvesting chlorophyll proteins (LHCPs) into thylakoid membranes. conserved component mechanism a membrane-bound receptor, denoted FtsY bacteria. Plant genomes encode homologs are targeted (cpFtsY). To investigate vivo roles cpFtsY, we characterized maize cpFtsY mutants having Mu transposon corresponding gene (chloroplast...
Polyploidy affects photosynthesis by causing changes in morphology, anatomy and biochemistry. However, newly developed polyploids, the genome may be unstable. In this study, diploid (2×) synthetic autotetraploids initial (4×-C0) 11th generations (4×-C11) of Phlox drummondii Hook were used to study effects chromosome doubling stabilisation on leaf anatomical properties. The light-saturated photosynthetic rate a area basis at 360 µmol CO2 mol-1 air (A360) was highest 4×-C11 leaves,...
Abstract Angiosperm leaves generally develop as bifacial structures with distinct adaxial and abaxial identities. However, several monocot species, such iris leek, unifacial leaves, in which leaf blades have only identity. In adaxial-abaxial polarity is required for blade flattening, whereas many become flattened despite their being abaxialized. Here, we investigate the mechanisms underlying development evolution of leaves. We demonstrate that abaxialized at gene expression level an ortholog...
Scope Nonalcoholic steatohepatitis (NASH) is a common disease, which closely associated with inflammation and oxidative stress, Lonicera caerulea L. polyphenols (LCP) are reported to possess both antioxidant anti‐inflammatory properties. This study aimed investigate the protective effects mechanisms of LCP on NASH in high‐fat diet plus carbon tetrachloride (CCL 4 ) induced mouse model. Methods results Mice were fed containing (0.5–1%) or not, then administrated CCL induce NASH. Liver...
The thyroid hormones have been reported to be associated with cognitive decline and Alzheimer's disease. relationship between function within the normal range cerebral blood flow in disease patients has shown a recent study. Mild impairment is often first stage of disease; thus, early diagnosis important. present study investigated regional mild A total 122 memory clinic outpatients who underwent testing single photon emission computed tomography were divided into impairment, disease, Normal...
Abstract 6‐(Methylsulfinyl)hexyl isothiocyanate (6‐MSITC), a major bioactive compound in Wasabi [ Wasabia japonica (Miq.) Matsum.], has revealed the inhibitory effect on colon carcinogenesis rat cancer model although underlying mechanism is unclear. In this study, we used two types of human colorectal cells (HCT116 p53 +/+ and HCT116 –/– ) to investigate anticancer activity molecular mechanisms 6‐MSITC. Interestingly, 6‐MSITC inhibited cell proliferation both with similar IC 50 value light...
Differences in the extent of cerebral white matter lesions (WML) and regional blood flow (rCBF) early-stage cognitive impairment (ESCI) contribute to prognosis decline; however, it is unclear precisely how WML rCBF affect decline ESCI.We examined association between WML, rCBF, ESCI, using path analysis clarify these variables each other.Eighty-three patients who consulted our memory clinic regarding loss were included this study based on Clinical Dementia Rating. Participants underwent...
The issue of whether serum lipid marker values are cognitively and neurologically significant for elderly individuals attending a memory clinic has been controversial. We investigated the associations markers with function cortical structure in 52 patients aged ≥75 years who had attended our based on their subjective complaints. None history medication hyperlipidemia. Wechsler Memory Scale-Revised (WMS-R) was administered to all assessment function. Serum low-density lipoprotein cholesterol,...
The Wechsler Memory Scale-Revised (WMS-R) is one of the internationally well-known batteries for memory assessment in a general clinic setting. Several factor structures WMS-R patients aged under 74 have been proposed. However, little known about structure over 75 years and its neurological significance. Thus, we conducted exploratory analysis to determine Regional cerebral blood flow (rCBF) was calculated from single-photon emission computed tomography data. Cortical thickness cortical...
6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a major bioactive compound in Wasabi. Although 6-MSITC reported to have cancer chemopreventive activities rat model, the molecular mechanism unclear. In this study, we investigated anticancer mechanisms using two types of human colorectal cells (HCT116 p53+/+ and p53-/-). caused cell cycle arrest G2/M phase induced apoptosis both same fashion. Signaling data revealed that activation ERK1/2, rather than p53, recruited for 6-MSITC-induced...