A5065697017- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Shoulder Injury and Treatment
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Rheumatoid Arthritis Research and Therapies
- Shoulder and Clavicle Injuries
- Musculoskeletal synovial abnormalities and treatments
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Neurofibromatosis and Schwannoma Cases
- RNA modifications and cancer
- Growth Hormone and Insulin-like Growth Factors
- Amino Acid Enzymes and Metabolism
- Peripheral Neuropathies and Disorders
- Inflammatory mediators and NSAID effects
- Spondyloarthritis Studies and Treatments
- Orthopedic Infections and Treatments
- ATP Synthase and ATPases Research
- Semiconductor materials and devices
- Colorectal Cancer Surgical Treatments
- Metabolism and Genetic Disorders
- Foot and Ankle Surgery
National Sagamihara Hospital
2021-2024
Tokyo Metropolitan Tama Medical Center
2020-2021
The University of Tokyo
2002-2019
Tokyo Medical and Dental University
2013-2017
Chubu University
2017
Kitasato University
2017
Chiba University
1984-2007
Saitama Medical University
2003-2005
NTT Basic Research Laboratories
2002
Gifu University
1995
A communication means is presented for patients with amyotrophic lateral sclerosis in totally locked-in state who are completely unable to move any part of the body and have no usual means. The method utilizes changes cerebral blood volume accompanied brain activity. When a patient asked question answer it ‘yes’, makes his or her active. change at frontal lobe detected near-infrared light. instantaneous amplitude phase calculated, maximum obtained. ‘yes’ ‘no’ using discriminant analysis...
Cell differentiation status is defined by the gene expression profile, which coordinately controlled epigenetic mechanisms. type-specific DNA methylation patterns are established chromatin modifiers including de novo methyltransferases, such as Dnmt3a and Dnmt3b. Since discovery of myogenic master MyoD, has been utilized a model system to study tissue differentiation. Although knowledge about networks accumulating, there only limited understanding how controls program. With an aim elucidate...
Although DNA methylation is considered to play an important role during myogenic differentiation, chronological alterations in and gene expression patterns this process have been poorly understood. Using the Infinium HumanMethylation450 BeadChip array, we obtained a profile of genome-wide status human myoblast differentiation model, where myoblasts were cultured low-serum medium stimulate differentiation. As proceeded, their global level increased became more distinct from those mesenchymal...
In this study, we investigated the changes in clinical outcome, treatment, and incidence of orthopedic surgery patients with rheumatoid arthritis (RA) from 2004 to 2014.Data were studied Japanese nationwide cohort database, NinJa (National Database Rheumatic Diseases by iR-net Japan), 2014. The time trends procedures analyzed using linear regression analysis. cross-sectional annual data compared between 2014 analyze outcome treatment.The surgeries RA consistently decreased 72.2 per 1000 51.5...
The effect of macrophages on proliferation granulosa cells was examined in gonadotrophin-primed immature female rats. mouse anti-rat macrophage monoclonal antibodies TRPM-2 and TRPM-3 were used observed the layer antrum follicles corpora lutea stroma around follicles. There no difference distribution between TRPM-2-positive TRPM-3-positive cells. Macrophages with some cytoplasmic vacuoles various sizes also demonstrated growing average ratios to preantral, antral mature 0.008, 0.007 0.002,...
Journal Article Comparison of the histological changes in skin DBA/2 and C57BL/6 mice following exposure to various promoting agents Get access Masashi Naito, Naito The University Texas System Cancer Center, Science Park—Research DivisionSmithville, TX 78957, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Yukiko John DiGiovanni Carcinogenesis, Volume 8, Issue 12, December 1987, Pages 1807–1815, https://doi.org/10.1093/carcin/8.12.1807 Published: 01 1987...
<h3>Importance</h3> Postoperative health care–associated infections are associated with a greater deterioration in patients' general status and social economic burden, at least 1 occurring approximately 4% of acute care hospital patients. Antimicrobial prophylaxis prevents surgical site various orthopedic procedures; however, its relationship remains unknown. <h3>Objective</h3> To examine whether shorter antimicrobial duration less than 24 hours after surgery is not inferior to longer...
Frozen shoulder (FS) is a common disorder characterized by spontaneous onset of pain accompanied progressive loss range-of-motions. The cause FS still unclear, and radical therapy has not been established. With the final aim preventing or curing at an earlier stage, we reviewed pathological biological features this disease. Many studies indicate that main pathology inflammation initially fibrosis later. There are inflammatory cytokines, immune cells, fibrotic growth factors, type-III...
Journal Article Susceptibility to phorbol ester skin tumor promotion in (C57BL/6×DBA/2) F 1 mice is inherited as an incomplete dominant trait: evidence for multi-locus involvement Get access Masashi Naito, Naito The University of Texas System Cancer Center, Science Park Research DivisionSmithville, TX 78957, USA Search other works by this author on: Oxford Academic PubMed Google Scholar Kristine J. Chenicek, Chenicek Yukiko John DiGiovanni To whom reprint requests should be sent...
Neoadjuvant chemoradiotherapy (NCRT) for advanced rectal cancer (RC) is a well-evidenced therapy; however, some RC patients have no therapeutic response. Patient selection NCRT so that non-responsive are excluded has been subjective. To date, molecular markers indicating radiation sensitivity reported.We irradiated six colorectal (CRC) cell lines and identified HCT116 cells as radiation-sensitive HCT15 DLD-1 resistant. Using microarray, we selected candidate marker genes by choosing whose...
To investigate the distribution of 25-question Geriatric Locomotive Function Scale (GLFS-25) scores in Japanese rheumatoid arthritis (RA) patients and evaluate relationships with clinical variables.Among 15,115 registered NinJa database for fiscal year 2015, 1710 complete GLFS-25 disease activity score-28 (DAS28) data were analyzed. Correlations between score variables assessed by Spearman coefficients. Mean compared among DAS28 groups (<2.6, 2.6-3.1, 3.2-5.0, ≥5.1) using Kruskal-Wallis...
To explore further the genetics of susceptibility skin tumor promotion in inbred mice, several aspects responsiveness to 12-O-etradecanoylphorbol-13-acetate (TPA) were examined C3H/He mice and segregating crosses between this mouse strain C57BL/6 as well BXD BXH recombinant (RI) strains. Dose-response relationships established for by TPA following initiation with 7, 12-dimethylbenz(a)anthracene B6C3F1, other stocks strains included comparison. The relative was: SENCAR > DBA/2 = B6D2F1 B6C3F1...
The incidence and severity of non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastro-duodenal ulcer have not been extensively studied in Japan.We performed a prospective study to clarify NSAIDs-induced injury, focusing especially on low-dose aspirin (L-A).Two hundred thirty-eight patients with bleeding peptic ulcers admitted our hospital. History taking NSAIDs anti-ulcer was obtained from all who underwent endoscopic examinations. lesion scores L-A were classified numerically zero (no...
A genetic analysis was done on the induction of trigeminal schwannomas by N-ethyl-N-nitrosourea [(ENU) CAS: 759-73-9] in susceptible LE rats, resistant WF and their F1, F2, reciprocal backcross hybrids. Both sexes all strains were given a neonatal sc injection 40 mg ENU/kg body weight sacrificed at 6 months after treatment. Many neurogenic tumors induced central nervous system rats. However, incidence rats 93% males 86% females, whereas 24% 20% females. F1 F2 hybrids showed an intermediate...