A5100624019- Developmental Biology and Gene Regulation
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Wnt/β-catenin signaling in development and cancer
- Congenital heart defects research
- Pluripotent Stem Cells Research
- Autonomous Vehicle Technology and Safety
- Remote Sensing and LiDAR Applications
- TGF-β signaling in diseases
- Advanced Chemical Sensor Technologies
- Metabolism and Genetic Disorders
- Clinical Nutrition and Gastroenterology
- Growth Hormone and Insulin-like Growth Factors
- Neonatal Respiratory Health Research
- Amino Acid Enzymes and Metabolism
- Robotics and Sensor-Based Localization
- Hypothalamic control of reproductive hormones
- Regulation of Appetite and Obesity
- Pregnancy and preeclampsia studies
- Genetics, Aging, and Longevity in Model Organisms
- Kruppel-like factors research
- Cancer-related gene regulation
- Advanced Sensor Technologies Research
- Liver physiology and pathology
- Enzyme Production and Characterization
Northwestern University
2021-2023
Seoul National University
1998-2021
Howard Hughes Medical Institute
2005-2017
Columbia University
2013-2017
Samsung (South Korea)
2016
King's College Hospital
2013-2014
University of California, Los Angeles
2005-2011
To address the patterning function of Bmp2, Bmp4 and Bmp7 growth factors, we designed antisense morpholino oligomers (MO) that block their activity in Xenopus laevis. knockdown was sufficient to rescue ventralizing effects caused by loss Chordin activity. Double inhibited tail development. Triple Bmp2/Bmp4/Bmp7 depletion further compromised trunk development but did not eliminate dorsoventral patterning. Unexpectedly, found blocking Spemann organizer formation UV treatment or beta-Catenin...
In Xenopus embryos, a dorsal-ventral patterning gradient is generated by diffusing Chordin/bone morphogenetic protein (BMP) complexes cleaved BMP1/Tolloid metalloproteinases in the ventral side. We developed new assay using fluorogenic Chordin peptide substrate and identified an unexpected negative feedback loop for BMP4, which BMP4 inhibits Tolloid enzyme activity noncompetitively. binds directly to CUB (Complement 1r/s, Uegf [a sea urchin embryonic protein] BMP1) domains of BMP1 Drosophila...
This paper proposes a lane marking detection method for automated driving in complex urban roads to be used with map-matching localization algorithms. First, LiDAR based and map matching algorithm is explained using AVM (Around View Monitor) cameras presented. The camera includes calibration, bird-eye view conversion, detection. two methods are combined implemented as part of on an autonomous test vehicle. Multiple experiments various routes, including situations like driver's license exam...
This paper presents a novel and efficient sensor fusion system for tracking multiple moving vehicles over Light Detection Ranging (LiDAR) Radar in autonomous vehicles. What is important the using LiDAR how well they utilize characteristics of each sensor. The proposed improves estimating accuracy maximum perception distance target by utilizing which has high wide Field View (FOV) observability relative speed. In addition, hypothesis (MHT) based track management extended Kalman filtering...
Abstract Gonadotropin‐releasing hormone (GnRH) is a pivotal neuroendocrine regulator controlling reproductive functions. However, the scattered distribution of GnRH neurones in mammalian brain has hindered studies on development and differentiation neurones. In present study, we used immortalized GnRH‐producing GT1‐1 cells to examine whether activation protein kinase C (PKC) pathway with 12‐ O ‐tetradecanoyl‐13‐acetate (TPA) induces morphological functional TPA induced neurite outgrowth...
Hypothalamic neurons regulate body homeostasis by sensing and integrating changes in the levels of key hormones primary nutrients (amino acids, glucose, lipids). However, molecular mechanisms that enable hypothalamic to detect remain elusive. Here, we identified l-type amino acid transporter 1 (LAT1) leptin receptor-expressing (LepR-expressing) as being important for systemic energy bone homeostasis. We observed LAT1-dependent uptake hypothalamus, which was compromised a mouse model obesity...
Gustatory information is relayed from the anterior tongue by geniculate ganglion neurons and posterior of petrosal portion jugular/nodose/petrosal complex. Here, we use in vivo calcium imaging mice to compare encoding taste ganglia, at single-neuron resolution. Our data support an anterior/posterior specialization coding with more responsive umami or bitter less sweet salty stimuli than neurons. We found that (50 mM MPG + 1 IMP) promotes salivation when applied posterior, but not anterior,...
We present a microneedle thermal flow sensor for measuring low speed liquid flows. Even though many types of have been developed, they are limited to measurements only in specific closed systems. However, our needle-shaped can be flexibly applied variety fluids. To predict operation, we conducted transport simulation based on multi-physics modeling comprising heat transfer fluids, laminar flow, and joule heating. Our measurement system consists needle shape sensor, fabricated by deep...
This paper presents an online static probability map and odometry estimation using automotive LiDAR for urban autonomous driving. In driving environment where high-rise buildings many vehicles exist, of vehicle is important factor perception localization accuracy. Therefore, this study aims to increase the accuracy in vulnerable GPS situations. The algorithm consists two point cloud processing modules. first module constructs (SPM) estimates correspondence between consecutive SPM. second...
<h3>Aims</h3> In infants with intestinal failure, it is known that episodes of sepsis can be accompanied by a significant deterioration in liver function. We hypothesised an intravenous lipid emulsion (ILE) comprised solely fish oil, such as Omegaven<sup>®</sup>, may protect the these during sepsis. Our aim to describe our single centre experience Omegaven<sup>®</sup> rescue therapy septic failure and or at risk developing disease. <h3>Methods</h3> A mixed source ILE containing both omega-3...
<h3>Aims</h3> In infants with intestinal failure-associated liver disease (IFALD), it is known that episodes of sepsis can be accompanied by a significant deterioration in function. We hypothesised an intravenous lipid emulsion (ILE) comprised solely fish oil, high omega-3 fatty acids, such as Omegaven<sup>®</sup>, may protect the these during sepsis. Our aim to describe potential role for Omegaven<sup>®</sup> rescue therapy and established IFALD. <h3>Methods</h3> A mixed source ILE...