A5018963519- Melanoma and MAPK Pathways
- Glioma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Bone Metabolism and Diseases
- Amino Acid Enzymes and Metabolism
- FOXO transcription factor regulation
- Bone health and treatments
- MicroRNA in disease regulation
- Fibroblast Growth Factor Research
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Mast cells and histamine
- Tuberous Sclerosis Complex Research
- Healthcare and Venom Research
- Lipid metabolism and disorders
- Mesenchymal stem cell research
- Wnt/β-catenin signaling in development and cancer
- Cytokine Signaling Pathways and Interactions
- Connective tissue disorders research
- Renal and related cancers
- Biopolymer Synthesis and Applications
- Cancer Diagnosis and Treatment
Gifu Pharmaceutical University
2020-2023
Bone marrow mesenchymal stem cells (MSCs) are critical regulators of postnatal bone homeostasis. Osteoporosis is characterized by volume and strength deterioration, partly due to MSC dysfunction. Cyclin-dependent kinase 8 (CDK8) belongs the transcription-related CDK family. Here, CDK8 in MSCs was identified as important for level increased aged along with association aging-related signals. Mouse genetic studies revealed that plays a crucial role resorption Mechanistically, extrinsically...
Abstract Glioma stem cells (GSCs) contribute to the pathogenesis of glioblastoma, most malignant form glioma. The implication and underlying mechanisms SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) on GSC phenotypes remain unknown. We previously demonstrated that SMURF2 phosphorylation at Thr 249 (SMURF2 Thr249 ) activates its activity. Here, we demonstrate plays an essential role in maintaining stemness tumorigenicity. silencing augmented self-renewal potential tumorigenicity...
Extracellular signal-regulated kinase 5 (Erk5) belongs to the mitogen-activated protein (MAPK) family. Previously, we demonstrated that Erk5 directly phosphorylates Smad-specific E3 ubiquitin ligase 2 (Smurf2) at Thr249 (Smurf2Thr249) activate its activity. Although have clarified importance of in embryonic mesenchymal stem cells (MSCs) on skeletogenesis, role adult bone marrow (BM)-MSCs homeostasis remains unknown. Leptin receptor-positive (LepR+) BM-MSCs represent a major source and are...
Glioma stem cells (GSC) promote the malignancy of glioblastoma (GBM), most lethal brain tumor. ERK5 belongs to MAPK family. Here, we demonstrated that kinase 5 (MEK5)-ERK5-STAT3 pathway plays an essential role in maintaining GSC stemness and tumorigenicity by integrating genetic pharmacologic manipulation RNA sequencing analysis clinical specimens. was highly expressed activated GSCs. silencing short hairpin GSCs suppressed self-renewal potential GBM malignant growth concomitant with...
Hypothalamic neurons regulate body homeostasis by sensing and integrating changes in the levels of key hormones primary nutrients (amino acids, glucose, lipids). However, molecular mechanisms that enable hypothalamic to detect remain elusive. Here, we identified l-type amino acid transporter 1 (LAT1) leptin receptor-expressing (LepR-expressing) as being important for systemic energy bone homeostasis. We observed LAT1-dependent uptake hypothalamus, which was compromised a mouse model obesity...
Royal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated effect development osteoarthritis (OA), most common degenerative joint disease. Here, we showed that daily oral administration raw significantly prevented OA in vivo following surgically-induced knee instability mice. Furthermore, vitro experiments using...
Abstract Scoliosis, usually diagnosed in childhood and early adolescence, is an abnormal lateral curvature of the spine. L‐type amino acid transporter 1 (LAT1), encoded by solute carrier 7a5 ( Slc7a5 ), plays a crucial role sensing signaling specific cell types. We previously demonstrated pivotal LAT1 on bone homeostasis mice, expression LAT1/ SLC7A5 vertebral cartilage pediatric scoliosis patients; however, its chondrocytes spinal implications regarding underlying mechanisms during onset...
Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, commonly used for the treatment of chronic diseases or frailty after an illness; however, its effects on metabolic bone such as osteoporosis are not well known. We herein report that daily oral Hochu-Ekki-To administration significantly inhibits osteoclast activation reduction in volume ovariectomized mice....
The mechanistic/mammalian target of rapamycin complex-1 (mTORC1) integrates multiple signaling pathways and regulates various cellular processes. Tuberous sclerosis complex 1 (Tsc1) 2 (Tsc2) are critical negative regulators mTORC1. Mouse genetic studies, including ours, have revealed that inactivation mTORC1 in undifferentiated mesenchymal cells chondrocytes leads to severe skeletal abnormalities, indicating a pivotal role for skeletogenesis. Here, we show hyperactivation influences...
<div><p>Glioma stem cells (GSC) promote the malignancy of glioblastoma (GBM), most lethal brain tumor. ERK5 belongs to MAPK family. Here, we demonstrated that kinase 5 (MEK5)-ERK5-STAT3 pathway plays an essential role in maintaining GSC stemness and tumorigenicity by integrating genetic pharmacologic manipulation RNA sequencing analysis clinical specimens. was highly expressed activated GSCs. <i>ERK5</i> silencing short hairpin GSCs suppressed self-renewal potential...
<div><p>Glioma stem cells (GSC) promote the malignancy of glioblastoma (GBM), most lethal brain tumor. ERK5 belongs to MAPK family. Here, we demonstrated that kinase 5 (MEK5)-ERK5-STAT3 pathway plays an essential role in maintaining GSC stemness and tumorigenicity by integrating genetic pharmacologic manipulation RNA sequencing analysis clinical specimens. was highly expressed activated GSCs. <i>ERK5</i> silencing short hairpin GSCs suppressed self-renewal potential...
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